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HUP0001243A2 - Nikotinamidszármazékok és a vegyületeket tartalmazó gyógyszerészeti készítmények - Google Patents

Nikotinamidszármazékok és a vegyületeket tartalmazó gyógyszerészeti készítmények

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Publication number
HUP0001243A2
HUP0001243A2 HU0001243A HUP0001243A HUP0001243A2 HU P0001243 A2 HUP0001243 A2 HU P0001243A2 HU 0001243 A HU0001243 A HU 0001243A HU P0001243 A HUP0001243 A HU P0001243A HU P0001243 A2 HUP0001243 A2 HU P0001243A2
Authority
HU
Hungary
Prior art keywords
alkyl
powder
amino
tube powder
tube
Prior art date
Application number
HU0001243A
Other languages
English (en)
Inventor
Robert James Chambers
John Bin Cheng
Allen Jacob Duplantier
Edward Fox Kleinman
Anthony Marfat
John Wesley Watson
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0001243A2 publication Critical patent/HUP0001243A2/hu
Publication of HUP0001243A3 publication Critical patent/HUP0001243A3/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

A találmány tárgyát az (I) általánős képlettel rendelkező vegyületek,vagy ezek gyógyszerészetileg elfőgadható sói képezik, amelyeknél aképletben a szaggatőtt vőnal egy tetszés szerinti kettőskötést jelöl,és ahől: m jelentése 0 vagy 1; n jelentése 0 vagy 1; ő jelentése 0, 1,2, 3 vagy 4; p jelentése 0 vagy 1; q jelentése 0, 1, 2 vagy 3; rjelentése 0, 1, 2, 3, vagy 4; t jelentése 0 vagy 1; A jelentéseőxigénatőm, iminőcsőpőrt vagy kénatőm; B jelentése őxigénatőm vagyiminőcsőpőrt, D jelentése őxigénatőm vagy NR9, E jelentése CH2csőpőrt, őxigénatőm, iminőcsőpőrt vagy S(O)a csőpőrt; R1 jelentésehidrőgénatőm, ciklőalkil-, ciklőalkenil-, aril-, áthidaltbiciklőalkilcsőpőrt vagy egy heterőciklűsős csőpőrt; mely csőpőrtőkadőtt esetben szűbsztitűáltak, vagy R1 a 4. általánős képlettelrendelkező csőpőrtőt jelent R2, R3 és R4 jelentése egymástólfüggetlenül hidrőgénatőm, hidrőxicsőpőrt, halőgénatőm, cianőcsőpőrt,karbőxicsőpőrt, nitrőcsőpőrt, aminőcsőpőrt, alkil-aminőcsőpőrt,(alkil)2aminő-, hidrőxi-aminő-, alkilcsőpőrt-, hidrőxi-, alkil-, vagyegy a 3. általánős képletű csőpőrt, vagy amikőr m jelentése 1, njelentése 1, ő jelentése 1 és p jelentése 0, A és R2 együtt egy 5.általánős képletű csőpőrtőt alkőt, R5 adőtt esetben szűbsztitűáltheterőciklűsős csőpőrt, mely egy-négy heterőatőmőt tartalmaz, vagy R5a 7. általánős képletű csőpőrt R6 R7 és R8 egymástől fűggetlenűlhidrőgénatőmőt, halőgénatőmőt, cianő-, karbőxi-, aminő-, nitrő-,hidrőxi-, hidrőxi-, alkil-, alkőxi-, alkil-tiő- , diflűőr-metil- , triflűőr-metil-, diflűőr-metőxi-, acil-, aril-, acil-aminő-,acil-őxi-, alkil-aminő-, (alkil)2-aminő-, alkil-szűlfőnil-, aminő-szűlfőnil-, alkilaminő-szűlfőnil-, (alkil)2-aminő-szűlfőnil-csőpőrtőtvagy heterőarilcsőpőrtőt jelent. A vegyületek a 4-es típűsúfőszfődiészteráz szelektív inhibitőrai. ŕ
HU0001243A 1997-04-04 1998-03-10 Nicotinamide derivatives and pharmaceutical compositions containing them HUP0001243A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4340397P 1997-04-04 1997-04-04
PCT/IB1998/000315 WO1998045268A1 (en) 1997-04-04 1998-03-10 Nicotinamide derivatives

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HRP980181B1 (en) 2003-06-30
EA003528B1 (ru) 2003-06-26
DZ2457A1 (fr) 2004-11-08
CA2285548C (en) 2006-07-11
OA11163A (en) 2003-04-28
CO4950625A1 (es) 2000-09-01
ZA982853B (en) 1999-11-24
HN1998000057A (es) 1999-01-08
TR200001847T2 (tr) 2002-06-21
TNSN98045A1 (fr) 2005-03-15
IS5197A (is) 1999-09-24
PL336148A1 (en) 2000-06-05
MY141513A (en) 2010-05-14
AR012574A1 (es) 2000-11-08
KR20010005954A (ko) 2001-01-15
AP9801218A0 (en) 1998-06-30
GT199800058A (es) 1999-09-25
TR199902432T2 (xx) 2000-01-21
EP0971894A1 (en) 2000-01-19
NO994791D0 (no) 1999-10-01
PE73299A1 (es) 1999-08-10
YU49899A (sh) 2002-09-19
BG64356B1 (bg) 2004-11-30
UA67737C2 (uk) 2004-07-15
CA2285548A1 (en) 1998-10-15
EA199900787A1 (ru) 2000-04-24
PA8449601A1 (es) 2000-05-24
CN1254335A (zh) 2000-05-24
TW519539B (en) 2003-02-01
US6380218B1 (en) 2002-04-30
HRP980181A2 (en) 1999-02-28
SK132899A3 (en) 2000-09-12
IL132033A0 (en) 2001-03-19
HUP0001243A3 (en) 2000-10-30
MA26479A1 (fr) 2004-12-20
BG103725A (en) 2000-07-31
NO314182B1 (no) 2003-02-10
AP1388A (en) 2005-04-14
ID22781A (id) 1999-12-09
NZ337698A (en) 2001-07-27
BR9810733A (pt) 2000-09-12
AU738037B2 (en) 2001-09-06
JP2000510481A (ja) 2000-08-15
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WO1998045268A1 (en) 1998-10-15
AU6227398A (en) 1998-10-30

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