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HUP0000591A2 - Fémproteáz inhibitor hatású piperazin-, morfolin- és tiomorfolin-származékok és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents

Fémproteáz inhibitor hatású piperazin-, morfolin- és tiomorfolin-származékok és alkalmazásuk gyógyszerkészítmények előállítására

Info

Publication number
HUP0000591A2
HUP0000591A2 HU0000591A HUP0000591A HUP0000591A2 HU P0000591 A2 HUP0000591 A2 HU P0000591A2 HU 0000591 A HU0000591 A HU 0000591A HU P0000591 A HUP0000591 A HU P0000591A HU P0000591 A2 HUP0000591 A2 HU P0000591A2
Authority
HU
Hungary
Prior art keywords
hydrogen atom
alkyl
morpholine
piperazine
heteroaryl
Prior art date
Application number
HU0000591A
Other languages
English (en)
Inventor
Neil Gregory Almstead
Menyan Cheng
Biswanath De
Randall Stryker Matthews
Michael George Natchus
Stanislaw Pikul
Yetunde Taiwo
Original Assignee
The Procter & Gamble Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Co. filed Critical The Procter & Gamble Co.
Publication of HUP0000591A2 publication Critical patent/HUP0000591A2/hu
Publication of HUP0000591A3 publication Critical patent/HUP0000591A3/hu

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    • C—CHEMISTRY; METALLURGY
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    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
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  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

A találmány tárgyát új (I) általános képletű vegyületek - ahol R1 hidrogénatom; R2 hidrogénatom, alkil- vagy acilcsoport; Ar -COR3 vagy -SO2R4 általános képletű csoport, amelyben R3 alkil-, aril-, heteroaril-, alkoxi-, aril-oxi-, heteroaril-oxi-,alkil-amino-, aril-amino- vagy heteroaril-amino-csoport; és R4 adott esetben szubsztituált alkil-, aril-, heteroarilcsoport; X oxigén-, kén- vagy szubsztituenst hordozó nitrogénatom; W hidrogénatom vagy alkilcsoport, vagy két szénatom közötti alkilén-,arilén- vagy heteroarilénhíd; vagy X és W együtt gyűrűt képeznek; Y hidrogénatom, hidroxi- vagy egyéb szubsztituens; és Z hidrogénatom, spirogyűrű vagy oxocsoport - és optikai izomereik,diasztereomereik, enantiomereik, gyógyászatilag elfogadható sóik vagybiológiailag hidrolizálható amidjaik, észtereik vagy imidjeik éshatóanyagként ezeket tartalmazó gyógyszerkészítmények képezik. Az (I) általános képletű vegyületek a fémproteáz-aktivitássaljellemzett betegségek, rendellenességek kezelésére alkalmazhatók. Ó
HU0000591A 1996-08-28 1997-08-22 Piperazine, morpholine and thiomorpholine derivatives as metalloprotease inhibitors and use of them for producing pharmaceutical compositions HUP0000591A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2476496P 1996-08-28 1996-08-28
PCT/US1997/014552 WO1998008825A1 (en) 1996-08-28 1997-08-22 1,4-heterocyclic metalloprotease inhibitors

Publications (2)

Publication Number Publication Date
HUP0000591A2 true HUP0000591A2 (hu) 2001-04-28
HUP0000591A3 HUP0000591A3 (en) 2001-07-30

Family

ID=21822288

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0000505A HUP0000505A3 (en) 1996-08-28 1997-08-22 Saturated 7-9 membered heterocyclic n-hydroxycarboxamide derivatives and pharmaceutical compositions containing them
HU0000591A HUP0000591A3 (en) 1996-08-28 1997-08-22 Piperazine, morpholine and thiomorpholine derivatives as metalloprotease inhibitors and use of them for producing pharmaceutical compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0000505A HUP0000505A3 (en) 1996-08-28 1997-08-22 Saturated 7-9 membered heterocyclic n-hydroxycarboxamide derivatives and pharmaceutical compositions containing them

Country Status (25)

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US (3) US6166005A (hu)
EP (2) EP0923563A1 (hu)
JP (2) JP2000516252A (hu)
KR (2) KR100339296B1 (hu)
CN (2) CN1228773A (hu)
AR (1) AR009356A1 (hu)
AT (1) ATE231132T1 (hu)
AU (2) AU731319B2 (hu)
BR (2) BR9712086A (hu)
CA (2) CA2263932A1 (hu)
CO (2) CO4920242A1 (hu)
CZ (2) CZ62399A3 (hu)
DE (1) DE69718480T2 (hu)
DK (1) DK0925287T3 (hu)
HU (2) HUP0000505A3 (hu)
ID (2) ID18142A (hu)
IL (2) IL128663A0 (hu)
NO (2) NO990760L (hu)
NZ (2) NZ334252A (hu)
PE (2) PE108998A1 (hu)
PL (2) PL331900A1 (hu)
SK (2) SK25199A3 (hu)
TR (2) TR199900400T2 (hu)
WO (2) WO1998008825A1 (hu)
ZA (2) ZA977694B (hu)

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* Cited by examiner, † Cited by third party
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BR9611929A (pt) * 1995-12-08 1999-05-18 Agouron Pharma Inibidores de metaloproteinase composições farmacéuticas contendo os mesmos e seus usos farmacéuticos e métodos e intermediários úteis
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
CZ62399A3 (cs) * 1996-08-28 1999-07-14 The Procter & Gamble Company 1,4-Heterocyklické metaloproteázové inhibitory
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
CA2275478A1 (en) 1996-12-17 1998-06-25 Kentaro Sato Piperazine compounds as inhibitors of mmp or tnf
BR9807678A (pt) 1997-02-11 2000-02-15 Pfizer Derivados de ácidos arilsulfonil-hidroxâmicos
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
HUP0004595A3 (en) 1997-07-31 2001-12-28 Procter & Gamble Acyclic metalloprotease inhibitors
US6403632B1 (en) * 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
US6107291A (en) * 1997-12-19 2000-08-22 Amgen Inc. Azepine or larger medium ring derivatives and methods of use
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
ID24957A (id) 1998-02-04 2000-08-31 Novartis Ag Turunan sulfonilamino yang menginhibisi metaloproteinase penurun matriks
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