HUE065571T2 - Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorként - Google Patents
Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorkéntInfo
- Publication number
- HUE065571T2 HUE065571T2 HUE20821141A HUE20821141A HUE065571T2 HU E065571 T2 HUE065571 T2 HU E065571T2 HU E20821141 A HUE20821141 A HU E20821141A HU E20821141 A HUE20821141 A HU E20821141A HU E065571 T2 HUE065571 T2 HU E065571T2
- Authority
- HU
- Hungary
- Prior art keywords
- benzothia
- dia
- bile acid
- acid modulators
- azepine compounds
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- 150000001538 azepines Chemical class 0.000 title 1
- 239000003613 bile acid Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911049982 | 2019-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE065571T2 true HUE065571T2 (hu) | 2024-06-28 |
Family
ID=73790062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE20821141A HUE065571T2 (hu) | 2019-12-04 | 2020-12-04 | Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorként |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR120679A1 (hu) |
| CL (1) | CL2022001453A1 (hu) |
| EC (1) | ECSP22040834A (hu) |
| HU (1) | HUE065571T2 (hu) |
| PT (1) | PT4069360T (hu) |
| TW (1) | TWI865673B (hu) |
| WO (1) | WO2021110883A1 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3400944B1 (en) | 2010-11-04 | 2020-07-15 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| WO2019234077A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| FI3921028T3 (fi) | 2019-02-06 | 2023-01-31 | Bentsotiadiatsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina | |
| PE20230234A1 (es) | 2019-12-04 | 2023-02-07 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar |
| CN116583504A (zh) | 2020-12-04 | 2023-08-11 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2023164181A1 (en) * | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164183A1 (en) * | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164179A1 (en) * | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164186A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023203248A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| CN119343140A (zh) | 2022-06-09 | 2025-01-21 | 阿尔比里奥公司 | 治疗肝炎 |
| WO2024008766A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202423921A (zh) * | 2022-08-22 | 2024-06-16 | 美商安塔製藥公司 | 稠合的雜雙環抗病毒劑 |
| WO2024163962A1 (en) * | 2023-02-03 | 2024-08-08 | Hemoshear Therapeutics, Inc. | 3-((1,1-dioxido-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)-2-fluoroacrylic acid derivatives as sodium taurocholate co-transporting polypeptide (ntcp) inhibitors for the treatment of cholestasis |
| WO2024177984A1 (en) * | 2023-02-20 | 2024-08-29 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
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| EP0489423B1 (de) | 1990-12-06 | 1996-11-06 | Hoechst Aktiengesellschaft | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel |
| ATE135380T1 (de) | 1991-12-20 | 1996-03-15 | Hoechst Ag | Polymere und oligomere von gallensäurederivaten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| ES2111092T3 (es) | 1992-06-12 | 1998-03-01 | Hoechst Ag | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos. |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| IL108633A (en) | 1993-02-15 | 1998-07-15 | Wellcome Found | History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them |
| TW289020B (hu) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| TW289757B (hu) | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| TW289021B (hu) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
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| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| AU700557B2 (en) | 1994-09-13 | 1999-01-07 | Monsanto Company | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| CA2248586A1 (en) | 1996-03-11 | 1997-09-18 | G.D. Searle & Co. | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| EP0912861B1 (de) | 1996-07-24 | 2000-11-29 | Zumtobel Staff GmbH | Adapter für ein haltemittel, welches zum befestigen einer einbauleuchte in einer einbauöffnung bestimmt ist, oder haltemittel oder einbauleuchte mit einem solchen adapter |
| DE19633268A1 (de) | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| JP2002500628A (ja) | 1997-03-11 | 2002-01-08 | ジー．ディー．サール アンド カンパニー | 回腸胆汁酸輸送阻害ベンゾチエピンおよびＨＭＧ Ｃｏ−Ａレダクターゼ阻害剤を用いた併用療法 |
| EP0864582B1 (en) | 1997-03-14 | 2003-06-04 | Aventis Pharma Deutschland GmbH | Hypolipidemic 1,4-benzothiazepine-1,-dioxides |
| GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
| DE19825804C2 (de) | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| EP1140191B1 (en) | 1998-12-23 | 2002-10-23 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and nicotinic acid derivatives for cardiovascular indications |
| ATE241386T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren |
| EP1140189B1 (en) | 1998-12-23 | 2003-05-14 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| DK1140190T3 (da) | 1998-12-23 | 2002-12-23 | Searle Llc | Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer |
| EA200100704A1 (ru) | 1998-12-23 | 2002-02-28 | Джи.Ди.Сирл Ллс | Комбинация для применения по сердечно-сосудистым показаниям |
| CA2362147A1 (en) | 1999-02-12 | 2000-08-17 | Steve A. Kolodziej | 1,2-benzothiazepines for the treatment of hyperlipidemic diseases |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| AU2001247331A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
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| MXPA04002179A (es) | 2001-09-08 | 2004-06-29 | Astrazeneca Ab | Derivados de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte del acido ileal biliar (ibat) para tratar hiperlipidemia. |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| WO2004020421A1 (ja) | 2002-08-28 | 2004-03-11 | Asahi Kasei Pharma Corporation | 新規な４級アンモニウム化合物 |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
| DE102005033100B3 (de) | 2005-07-15 | 2007-01-25 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
| US9295677B2 (en) | 2008-02-26 | 2016-03-29 | Qing Bile Therapeutics Inc. | Polyhydroxylated bile acids for treatment of biliary disorders |
| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
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| KR101674806B1 (ko) | 2014-10-20 | 2016-11-10 | 씨제이헬스케어 주식회사 | 신규한 아미노알킬벤조티아제핀 유도체 및 이의 용도 |
| KR20160061492A (ko) | 2014-11-21 | 2016-06-01 | 삼성디스플레이 주식회사 | 휴대용 먼지 센서 및 이를 이용한 휴대전화 |
| EP3413877B1 (en) | 2016-02-09 | 2021-04-07 | Albireo AB | Oral cholestyramine formulation and use thereof |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| US11350844B2 (en) | 2016-11-23 | 2022-06-07 | Mayo Foundation For Medical Education And Research | System and method for generating nonalcoholic fatty liver disease activity score (NAS) using magnetic resonance elastography |
| CA3071182A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
| EP3664781A1 (en) | 2017-08-09 | 2020-06-17 | Albireo AB | Cholestyramine granules, oral cholestyramine formulations and use thereof |
| MX2020009332A (es) * | 2018-03-09 | 2020-10-08 | Elobix Ab | Proceso para la preparacion de elobixibat. |
| WO2019234077A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US10793534B2 (en) * | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
| FI3921028T3 (fi) | 2019-02-06 | 2023-01-31 | Bentsotiadiatsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina |
-
2020
- 2020-12-04 HU HUE20821141A patent/HUE065571T2/hu unknown
- 2020-12-04 AR ARP200103391A patent/AR120679A1/es unknown
- 2020-12-04 TW TW109142972A patent/TWI865673B/zh active
- 2020-12-04 WO PCT/EP2020/084567 patent/WO2021110883A1/en active Application Filing
- 2020-12-04 PT PT208211417T patent/PT4069360T/pt unknown
-
2022
- 2022-05-19 EC ECSENADI202240834A patent/ECSP22040834A/es unknown
- 2022-06-02 CL CL2022001453A patent/CL2022001453A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR120679A1 (es) | 2022-03-09 |
| CL2022001453A1 (es) | 2023-06-02 |
| WO2021110883A1 (en) | 2021-06-10 |
| PT4069360T (pt) | 2024-03-06 |
| TWI865673B (zh) | 2024-12-11 |
| TW202134223A (zh) | 2021-09-16 |
| ECSP22040834A (es) | 2022-06-30 |
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