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HUE053449T2 - Kompozíciók, amelyek tartalmazzák lizinspecifikus demetiláz-1 inhibitorát, amelynek van pirimidingyûrûje és azok felhasználása rák kezelésében - Google Patents

Kompozíciók, amelyek tartalmazzák lizinspecifikus demetiláz-1 inhibitorát, amelynek van pirimidingyûrûje és azok felhasználása rák kezelésében

Info

Publication number
HUE053449T2
HUE053449T2 HUE16863111A HUE16863111A HUE053449T2 HU E053449 T2 HUE053449 T2 HU E053449T2 HU E16863111 A HUE16863111 A HU E16863111A HU E16863111 A HUE16863111 A HU E16863111A HU E053449 T2 HUE053449 T2 HU E053449T2
Authority
HU
Hungary
Prior art keywords
lysine
cancer
inhibitor
compositions
treatment
Prior art date
Application number
HUE16863111A
Other languages
English (en)
Inventor
Young K Chen
Toufike Kanouni
Stephen W Kaldor
Jeffrey Alan Stafford
James Marvin Veal
Paula Alessandra Tavares-Greco
Matthew Michael Kreilein
Original Assignee
Celgene Quanticel Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Quanticel Res Inc filed Critical Celgene Quanticel Res Inc
Publication of HUE053449T2 publication Critical patent/HUE053449T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • C07D239/36One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HUE16863111A 2015-11-05 2016-11-04 Kompozíciók, amelyek tartalmazzák lizinspecifikus demetiláz-1 inhibitorát, amelynek van pirimidingyûrûje és azok felhasználása rák kezelésében HUE053449T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562251507P 2015-11-05 2015-11-05

Publications (1)

Publication Number Publication Date
HUE053449T2 true HUE053449T2 (hu) 2021-06-28

Family

ID=58662888

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16863111A HUE053449T2 (hu) 2015-11-05 2016-11-04 Kompozíciók, amelyek tartalmazzák lizinspecifikus demetiláz-1 inhibitorát, amelynek van pirimidingyûrûje és azok felhasználása rák kezelésében

Country Status (21)

Country Link
US (4) US9828358B2 (hu)
EP (1) EP3371152B1 (hu)
JP (1) JP6995043B2 (hu)
CN (1) CN108473442B (hu)
AR (1) AR106612A1 (hu)
AU (1) AU2016349707B2 (hu)
CA (1) CA3004300C (hu)
CY (1) CY1124078T1 (hu)
DK (1) DK3371152T3 (hu)
ES (1) ES2846951T3 (hu)
HR (1) HRP20210144T8 (hu)
HU (1) HUE053449T2 (hu)
LT (1) LT3371152T (hu)
MX (2) MX2020004894A (hu)
PL (1) PL3371152T3 (hu)
PT (1) PT3371152T (hu)
RS (1) RS61404B1 (hu)
SI (1) SI3371152T1 (hu)
SM (1) SMT202100044T1 (hu)
TW (1) TW201720808A (hu)
WO (1) WO2017079670A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016025248B1 (pt) 2014-05-01 2022-12-13 Celgene Quanticel Research, Inc Compostos inibidores de demetilase lisina-específica-1, composição farmacêutica e seus usos
CA3004300C (en) * 2015-11-05 2023-08-22 Celgene Quanticel Research, Inc. Compositions comprising an inhibitor of lysine specific demethylase-1
US20190256930A1 (en) 2016-11-03 2019-08-22 Oryzon Genomics, S.A. Biomarkers for determining responsiveness to lsd1 inhibitors
EP3551178A1 (en) 2016-12-09 2019-10-16 Constellation Pharmaceuticals, Inc. Markers for personalized cancer treatment with lsd1 inhibitors
DK3661510T3 (da) 2017-08-03 2025-01-02 Oryzon Genomics Sa Fremgangsmåder til behandling af adfærdsændringer
CN113631164A (zh) 2019-03-20 2021-11-09 奥莱松基因组股份有限公司 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法
SG11202109159VA (en) 2019-03-20 2021-10-28 Oryzon Genomics Sa Methods of treating borderline personality disorder
CN115135324A (zh) * 2019-06-13 2022-09-30 细胞基因公司 通过靶向冷肿瘤治疗癌症的方法
WO2020257665A1 (en) * 2019-06-20 2020-12-24 Celgene Corporation Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome
JP2022546908A (ja) 2019-07-05 2022-11-10 オリゾン・ゲノミクス・ソシエダッド・アノニマ Kdm1a阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
CN116056707A (zh) * 2020-06-05 2023-05-02 赛尔基因昆蒂赛尔研究公司 治疗前列腺癌的方法
ES2919083R1 (es) * 2020-06-29 2022-07-26 Celgene Quanticel Res Inc Métodos de tratamiento de cáncer de próstata
MX2023011779A (es) 2021-04-08 2023-11-22 Oryzon Genomics Sa Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides.
EP4522137A1 (en) 2022-05-09 2025-03-19 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
CN119546292A (zh) 2022-05-09 2025-02-28 奥莱松基因组股份有限公司 使用lsd1抑制剂治疗恶性周围神经鞘瘤(mpnst)的方法
WO2024110649A1 (en) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US7101873B2 (en) * 2002-04-10 2006-09-05 Bexel Pharmaceuticals Inc. Pyrimidinedione derivatives
WO2003084937A2 (en) 2002-04-10 2003-10-16 Orchid Chemicals & Pharmaceuticals Limited Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases
JP2008515902A (ja) * 2004-10-06 2008-05-15 エヌピーエス ファーマシューティカルズ インコーポレイテッド カルシウム拮抗化合物としての相補ピリミジノン化合物
US20100137313A1 (en) * 2008-10-03 2010-06-03 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
EP3094627B1 (en) * 2014-01-17 2018-08-22 Novartis AG 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and and compositions thereof for inhibiting the activity of shp2
BR112016025248B1 (pt) * 2014-05-01 2022-12-13 Celgene Quanticel Research, Inc Compostos inibidores de demetilase lisina-específica-1, composição farmacêutica e seus usos
CA3004300C (en) * 2015-11-05 2023-08-22 Celgene Quanticel Research, Inc. Compositions comprising an inhibitor of lysine specific demethylase-1

Also Published As

Publication number Publication date
SMT202100044T1 (it) 2021-05-07
WO2017079670A9 (en) 2017-06-15
CA3004300C (en) 2023-08-22
CN108473442A (zh) 2018-08-31
US9828358B2 (en) 2017-11-28
JP2019500323A (ja) 2019-01-10
MX2018005620A (es) 2018-08-01
RS61404B1 (sr) 2021-02-26
HRP20210144T1 (hr) 2021-03-05
PL3371152T3 (pl) 2021-06-28
ES2846951T3 (es) 2021-07-30
CY1124078T1 (el) 2022-05-27
EP3371152A1 (en) 2018-09-12
EP3371152B1 (en) 2020-12-23
MX2020004894A (es) 2021-11-03
US20170129871A1 (en) 2017-05-11
TW201720808A (zh) 2017-06-16
PT3371152T (pt) 2021-02-01
SI3371152T1 (sl) 2021-06-30
AU2016349707A1 (en) 2018-05-24
JP6995043B2 (ja) 2022-02-04
US20180319767A1 (en) 2018-11-08
WO2017079670A1 (en) 2017-05-11
MX373363B (es) 2025-03-05
LT3371152T (lt) 2021-04-12
US10047069B2 (en) 2018-08-14
CA3004300A1 (en) 2017-05-11
DK3371152T3 (da) 2021-02-15
AU2016349707B2 (en) 2020-12-10
US20190367473A1 (en) 2019-12-05
US10703739B2 (en) 2020-07-07
CN108473442B (zh) 2022-03-25
HRP20210144T8 (hr) 2021-04-16
US20180044320A1 (en) 2018-02-15
EP3371152A4 (en) 2019-07-03
US10316016B2 (en) 2019-06-11
AR106612A1 (es) 2018-01-31

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