HUE042763T2 - Módosított szerpinek vérzési rendellenességek kezelésére - Google Patents

Módosított szerpinek vérzési rendellenességek kezelésére

Info

Publication number: HUE042763T2
Authority: HU; Hungary
Prior art keywords: treatment; bleeding disorders; modified serpins; serpins; modified
Prior art date: 2013-12-13

Application number

HUE14827185A

Other languages

English (en)

Inventor

James Andrew Huntington

Stephanie Polderdijk

Trevor Baglin

Original Assignee

Cambridge Entpr Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-13

Filing date

2014-12-15

Publication date

2019-07-29

2014-12-15 Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd

2019-07-29 Publication of HUE042763T2 publication Critical patent/HUE042763T2/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

HUE14827185A 2013-12-13 2014-12-15 Módosított szerpinek vérzési rendellenességek kezelésére HUE042763T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB1322091.8A GB201322091D0 (en)	2013-12-13	2013-12-13	Modified serpins for the treatment of bleeding disorders

Publications (1)

Publication Number	Publication Date
HUE042763T2 true HUE042763T2 (hu)	2019-07-29

Family

ID=50030900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE14827185A HUE042763T2 (hu)	2013-12-13	2014-12-15	Módosított szerpinek vérzési rendellenességek kezelésére

Country Status (25)

Country	Link
US (2)	US9982035B2 (hu)
EP (2)	EP3080157B1 (hu)
JP (2)	JP6431541B2 (hu)
KR (2)	KR101954945B1 (hu)
CN (2)	CN105992771B (hu)
AU (2)	AU2014363359B2 (hu)
CA (1)	CA2933508C (hu)
CY (1)	CY1121267T1 (hu)
DK (1)	DK3080157T3 (hu)
EA (1)	EA034050B1 (hu)
ES (1)	ES2704058T3 (hu)
GB (1)	GB201322091D0 (hu)
HR (1)	HRP20182138T1 (hu)
HU (1)	HUE042763T2 (hu)
IL (2)	IL246180B (hu)
LT (1)	LT3080157T (hu)
MX (1)	MX357941B (hu)
NZ (1)	NZ721918A (hu)
PL (1)	PL3080157T3 (hu)
PT (1)	PT3080157T (hu)
RS (1)	RS58191B1 (hu)
SI (1)	SI3080157T1 (hu)
SM (1)	SMT201900016T1 (hu)
TR (1)	TR201819781T4 (hu)
WO (1)	WO2015086854A1 (hu)

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GB201322091D0 (en)	2013-12-13	2014-01-29	Cambridge Entpr Ltd	Modified serpins for the treatment of bleeding disorders
WO2017007994A1 (en)	2015-07-08	2017-01-12	American Gene Technologies International Inc.	Hiv pre-immunization and immunotherapy
US10888613B2 (en)	2016-02-08	2021-01-12	American Gene Technologies International Inc.	Method of producing cells resistant to HIV infection
ES2911448T3 (es)	2016-03-09	2022-05-19	American Gene Tech Int Inc	Vectores combinados y métodos para el tratamiento del cáncer
EP3468617A4 (en)	2016-06-08	2020-01-22	American Gene Technologies International Inc.	INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS
EP3481418A4 (en)	2016-07-08	2020-03-11	American Gene Technologies International Inc.	PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV
WO2018154044A1 (en) *	2017-02-23	2018-08-30	Umc Utrecht Holding B.V.	Modified serpins for the treatment of bradykinin-mediated disease
EP3607072A4 (en)	2017-04-03	2021-01-06	American Gene Technologies International Inc.	COMPOSITIONS AND METHODS OF TREATMENT OF PHENYLCETONURISM
RU2663464C1 (ru) *	2018-02-26	2018-08-06	Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум"	Комбинаторная терапия для лечения геморрагического шока
US20210388059A1 (en) *	2018-10-29	2021-12-16	Spin Therapeutics, Llc	Compositions and methods for alpha-1-antitrypsin disorders
CN110051830A (zh) *	2019-03-14	2019-07-26	苏州新凝生物医药科技有限公司	一种protease nexin II\KPI蛋白突变体的应用
WO2022226451A1 (en) *	2021-04-20	2022-10-27	University Of Louisville	Recombinant miropin
WO2023118150A1 (en)	2021-12-22	2023-06-29	Royal College Of Surgeons In Ireland	A conjugate for use in localising a molecule to the vascular endothelium.

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FR2599752B1 (fr)	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
DE3705745A1 (de)	1987-02-23	1988-09-01	Behringwerke Ag	Protein c-inhibitor (pci) als pharmazeutikum und in vitro-diagnostikum, verfahren zur herstellung eines solchen pharmazeutikums oder diagnostikums sowie ein mittel enthaltend pci
US5612194A (en)	1989-06-23	1997-03-18	Trustees Of The University Of Pennsylvania	Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
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JP2002010783A (ja)	2000-06-29	2002-01-15	Jcr Pharmaceuticals Co Ltd	改変型ヒトプロテインｃインヒビター
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EP2055783A1 (en) *	2007-10-30	2009-05-06	VIB vzw	Insect inhibiting plant serpin mutants
AU2008319183B2 (en)	2007-11-01	2014-09-04	University Of Rochester	Recombinant factor VIII having increased stability
CN101977626A (zh) *	2008-01-21	2011-02-16	德莫迪斯公司	丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途
EP2379101B1 (en)	2009-01-16	2018-09-12	Université Paris-Sud XI	Mutated antithrombins, a process for preparing the same and their use as drugs
WO2010123290A2 (ko) *	2009-04-22	2010-10-28	(주)알테오젠	체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법
WO2011123830A2 (en) *	2010-04-02	2011-10-06	Amunix Operating Inc.	Alpha 1-antitrypsin compositions and methods of making and using same
US9127274B2 (en)	2012-04-26	2015-09-08	Alnylam Pharmaceuticals, Inc.	Serpinc1 iRNA compositions and methods of use thereof
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GB201322091D0 (en)	2013-12-13	2014-01-29	Cambridge Entpr Ltd	Modified serpins for the treatment of bleeding disorders
WO2018154044A1 (en) *	2017-02-23	2018-08-30	Umc Utrecht Holding B.V.	Modified serpins for the treatment of bradykinin-mediated disease

2013
- 2013-12-13 GB GBGB1322091.8A patent/GB201322091D0/en not_active Ceased
2014
- 2014-12-15 HU HUE14827185A patent/HUE042763T2/hu unknown
- 2014-12-15 LT LTEP14827185.1T patent/LT3080157T/lt unknown
- 2014-12-15 SM SM20190016T patent/SMT201900016T1/it unknown
- 2014-12-15 CA CA2933508A patent/CA2933508C/en active Active
- 2014-12-15 RS RS20181470A patent/RS58191B1/sr unknown
- 2014-12-15 KR KR1020167018756A patent/KR101954945B1/ko active Active
- 2014-12-15 ES ES14827185T patent/ES2704058T3/es active Active
- 2014-12-15 CN CN201480075522.6A patent/CN105992771B/zh active Active
- 2014-12-15 EA EA201691235A patent/EA034050B1/ru unknown
- 2014-12-15 PT PT14827185T patent/PT3080157T/pt unknown
- 2014-12-15 NZ NZ721918A patent/NZ721918A/en unknown
- 2014-12-15 SI SI201430967T patent/SI3080157T1/sl unknown
- 2014-12-15 EP EP14827185.1A patent/EP3080157B1/en active Active
- 2014-12-15 PL PL14827185T patent/PL3080157T3/pl unknown
- 2014-12-15 MX MX2016007711A patent/MX357941B/es active IP Right Grant
- 2014-12-15 CN CN201910704484.0A patent/CN110330563B/zh active Active
- 2014-12-15 AU AU2014363359A patent/AU2014363359B2/en active Active
- 2014-12-15 TR TR2018/19781T patent/TR201819781T4/tr unknown
- 2014-12-15 KR KR1020197006015A patent/KR102186924B1/ko active Active
- 2014-12-15 WO PCT/EP2014/077783 patent/WO2015086854A1/en active Application Filing
- 2014-12-15 JP JP2016538525A patent/JP6431541B2/ja active Active
- 2014-12-15 DK DK14827185.1T patent/DK3080157T3/en active
- 2014-12-15 US US15/103,420 patent/US9982035B2/en active Active
- 2014-12-15 EP EP18190334.5A patent/EP3434689A1/en not_active Withdrawn
2016
- 2016-06-13 IL IL246180A patent/IL246180B/en active IP Right Grant
2018
- 2018-05-04 US US15/971,692 patent/US10351619B2/en active Active
- 2018-10-31 JP JP2018204779A patent/JP6723319B2/ja active Active
- 2018-11-08 IL IL262879A patent/IL262879A/en unknown
- 2018-12-17 AU AU2018279054A patent/AU2018279054A1/en not_active Abandoned
- 2018-12-18 HR HRP20182138TT patent/HRP20182138T1/hr unknown
- 2018-12-27 CY CY20181101396T patent/CY1121267T1/el unknown

Also Published As

Publication number	Publication date
PL3080157T3 (pl)	2019-03-29
CN110330563A (zh)	2019-10-15
EP3080157A1 (en)	2016-10-19
HRP20182138T1 (hr)	2019-02-08
MX357941B (es)	2018-07-31
TR201819781T4 (tr)	2019-01-21
EA034050B1 (ru)	2019-12-23
CN110330563B (zh)	2024-03-29
EP3080157B1 (en)	2018-10-03
US10351619B2 (en)	2019-07-16
PT3080157T (pt)	2019-01-11
NZ721918A (en)	2019-12-20
GB201322091D0 (en)	2014-01-29
JP6431541B2 (ja)	2018-11-28
AU2018279054A1 (en)	2019-01-17
IL246180A0 (en)	2016-07-31
AU2014363359B2 (en)	2019-01-03
EA201691235A1 (ru)	2016-12-30
KR102186924B1 (ko)	2020-12-04
KR101954945B1 (ko)	2019-03-07
KR20190022945A (ko)	2019-03-06
CN105992771A (zh)	2016-10-05
SMT201900016T1 (it)	2019-02-28
CA2933508A1 (en)	2015-06-18
BR112016013591A2 (pt)	2017-10-03
JP6723319B2 (ja)	2020-07-15
WO2015086854A1 (en)	2015-06-18
EP3434689A1 (en)	2019-01-30
KR20160092025A (ko)	2016-08-03
CN105992771B (zh)	2019-08-23
JP2019037242A (ja)	2019-03-14
LT3080157T (lt)	2018-12-10
US9982035B2 (en)	2018-05-29
DK3080157T3 (en)	2018-12-17
AU2014363359A1 (en)	2016-07-21
JP2017505114A (ja)	2017-02-16
MX2016007711A (es)	2016-12-09
CY1121267T1 (el)	2020-05-29
ES2704058T3 (es)	2019-03-14
IL262879A (en)	2018-12-31
IL246180B (en)	2018-11-29
SI3080157T1 (sl)	2018-12-31
US20180273610A1 (en)	2018-09-27
RS58191B1 (sr)	2019-03-29
CA2933508C (en)	2021-04-06
US20160311887A1 (en)	2016-10-27

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