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HU9900958D0 - New derivatives of 2-fluoro-3-de[(2,6-dideoxy-3-c-methyl-3-0-methyl-alfa-l-ribohexopyranosyl)-oxy]-6-0-methyl-3-oxo-erytromycin, their preparation process and their use for the synthesis of the active ingredients of medicaments - Google Patents

New derivatives of 2-fluoro-3-de[(2,6-dideoxy-3-c-methyl-3-0-methyl-alfa-l-ribohexopyranosyl)-oxy]-6-0-methyl-3-oxo-erytromycin, their preparation process and their use for the synthesis of the active ingredients of medicaments

Info

Publication number
HU9900958D0
HU9900958D0 HU9900958A HUP9900958A HU9900958D0 HU 9900958 D0 HU9900958 D0 HU 9900958D0 HU 9900958 A HU9900958 A HU 9900958A HU P9900958 A HUP9900958 A HU P9900958A HU 9900958 D0 HU9900958 D0 HU 9900958D0
Authority
HU
Hungary
Prior art keywords
methyl
dideoxy
oxy
oxo
fluoro
Prior art date
Application number
HU9900958A
Other languages
English (en)
Inventor
Alain Bonnet
Francoise Gambier
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of HU9900958D0 publication Critical patent/HU9900958D0/hu
Publication of HUP9900958A1 publication Critical patent/HUP9900958A1/hu
Publication of HUP9900958A3 publication Critical patent/HUP9900958A3/hu
Publication of HU227562B1 publication Critical patent/HU227562B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9900958A 1998-04-08 1999-04-07 Derivatives of 2-fluoro-3-de[(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribohexopyranosyl)-oxy]-6-o-methyl-3-oxo-erythromycin, and their preparation process HU227562B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804366A FR2777282B1 (fr) 1998-04-08 1998-04-08 Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (4)

Publication Number Publication Date
HU9900958D0 true HU9900958D0 (en) 1999-06-28
HUP9900958A1 HUP9900958A1 (hu) 1999-11-29
HUP9900958A3 HUP9900958A3 (en) 2000-04-28
HU227562B1 HU227562B1 (en) 2011-08-29

Family

ID=9524992

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900958A HU227562B1 (en) 1998-04-08 1999-04-07 Derivatives of 2-fluoro-3-de[(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribohexopyranosyl)-oxy]-6-o-methyl-3-oxo-erythromycin, and their preparation process

Country Status (12)

Country Link
US (1) US6121432A (hu)
EP (1) EP0949268B1 (hu)
JP (1) JP4707785B2 (hu)
KR (1) KR100633835B1 (hu)
CN (1) CN1130370C (hu)
AT (1) ATE256139T1 (hu)
DE (1) DE69913413T2 (hu)
DK (1) DK0949268T3 (hu)
ES (1) ES2210999T3 (hu)
FR (1) FR2777282B1 (hu)
HU (1) HU227562B1 (hu)
PT (1) PT949268E (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1147121E (pt) 1999-01-27 2004-04-30 Pfizer Prod Inc Antibioticos cetolidos
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
AU4354900A (en) 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000063225A2 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
TR200103395T2 (tr) * 1999-05-24 2002-04-22 Pfizer Products Inc. 13-metil eritromisin türevleri.
JP2001261694A (ja) 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
TR200401847T4 (tr) 2000-06-30 2004-09-21 Pfizer Products Inc. Makrolit antibiyotikler.
EP2664331B1 (en) 2003-03-10 2015-09-16 Merck Sharp & Dohme Corp. Novel Antibacterial Agents
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) * 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
JP5851516B2 (ja) * 2010-12-09 2016-02-03 ウォックハート リミテッド ケトライド化合物
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
KR20160020403A (ko) 2013-03-15 2016-02-23 셈프라 파마슈티컬스, 인크. 매크로라이드 항세균제들을 제조하기 위한 수렴 프로세스들
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (en) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
WO1993021200A1 (fr) * 1992-04-22 1993-10-28 Taisho Pharmaceutical Co., Ltd. Derive de 5-o-desosaminylerythronolide a
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

Also Published As

Publication number Publication date
PT949268E (pt) 2004-04-30
CN1235162A (zh) 1999-11-17
HUP9900958A3 (en) 2000-04-28
HUP9900958A1 (hu) 1999-11-29
DE69913413T2 (de) 2004-12-02
FR2777282B1 (fr) 2001-04-20
US6121432A (en) 2000-09-19
JPH11310591A (ja) 1999-11-09
KR100633835B1 (ko) 2006-10-13
EP0949268B1 (fr) 2003-12-10
FR2777282A1 (fr) 1999-10-15
KR19990082977A (ko) 1999-11-25
CN1130370C (zh) 2003-12-10
ATE256139T1 (de) 2003-12-15
HU227562B1 (en) 2011-08-29
DK0949268T3 (da) 2004-03-29
JP4707785B2 (ja) 2011-06-22
ES2210999T3 (es) 2004-07-01
EP0949268A1 (fr) 1999-10-13
DE69913413D1 (de) 2004-01-22

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