HU198480B - Process for producing furaltadone-mesylate salt and pharmaceutical compositions comprising this salt - Google Patents
Process for producing furaltadone-mesylate salt and pharmaceutical compositions comprising this salt Download PDFInfo
- Publication number
- HU198480B HU198480B HU872556A HU255687A HU198480B HU 198480 B HU198480 B HU 198480B HU 872556 A HU872556 A HU 872556A HU 255687 A HU255687 A HU 255687A HU 198480 B HU198480 B HU 198480B
- Authority
- HU
- Hungary
- Prior art keywords
- furaltadone
- mesylate
- salt
- water
- mesylate salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 9
- 150000003839 salts Chemical class 0.000 title abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 33
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000007864 aqueous solution Substances 0.000 claims abstract description 4
- 150000004677 hydrates Chemical class 0.000 claims abstract description 3
- 229950000337 furaltadone Drugs 0.000 claims description 33
- YVQVOQKFMFRVGR-VGOFMYFVSA-N 5-(morpholin-4-ylmethyl)-3-[(e)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OC(CN2CCOCC2)C1 YVQVOQKFMFRVGR-VGOFMYFVSA-N 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- -1 4-morpholinylmethyl Chemical group 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000003756 stirring Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- YVQVOQKFMFRVGR-UHFFFAOYSA-N furaltadone Chemical compound O1C([N+](=O)[O-])=CC=C1C=NN1C(=O)OC(CN2CCOCC2)C1 YVQVOQKFMFRVGR-UHFFFAOYSA-N 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL79174A IL79174A0 (en) | 1986-06-05 | 1986-06-05 | Water soluble salt of furaltadone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT47566A HUT47566A (en) | 1989-03-28 |
| HU198480B true HU198480B (en) | 1989-10-30 |
Family
ID=11056879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU872556A HU198480B (en) | 1986-06-05 | 1987-06-04 | Process for producing furaltadone-mesylate salt and pharmaceutical compositions comprising this salt |
Country Status (5)
| Country | Link |
|---|---|
| FR (1) | FR2599741B1 (it) |
| HU (1) | HU198480B (it) |
| IL (1) | IL79174A0 (it) |
| IT (1) | IT1205117B (it) |
| NL (1) | NL8701269A (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE188696T1 (de) * | 1991-08-14 | 2000-01-15 | Procter & Gamble Pharma | Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1093881A (en) * | 1964-02-04 | 1967-12-06 | Esteve Labor Dr | Process for obtaining water-soluble derivatives of nitrofurans |
| FR1520654A (fr) * | 1966-11-23 | 1968-04-12 | Esteve Labor Dr | Procédé de préparation d'hydroxy-benzène sulfonates de dérivés de la morpholine |
-
1986
- 1986-06-05 IL IL79174A patent/IL79174A0/xx not_active IP Right Cessation
-
1987
- 1987-05-27 NL NL8701269A patent/NL8701269A/nl unknown
- 1987-05-29 FR FR878707532A patent/FR2599741B1/fr not_active Expired
- 1987-06-01 IT IT8720745A patent/IT1205117B/it active
- 1987-06-04 HU HU872556A patent/HU198480B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2599741A1 (fr) | 1987-12-11 |
| NL8701269A (nl) | 1988-01-04 |
| IT8720745A0 (it) | 1987-06-01 |
| HUT47566A (en) | 1989-03-28 |
| FR2599741B1 (fr) | 1989-12-22 |
| IL79174A0 (en) | 1986-09-30 |
| IT1205117B (it) | 1989-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69500652T2 (de) | Nefazodon-Salze mit verbesserter Auflösungsgeschwindigkeit | |
| JPS58174319A (ja) | 薬剤組成物 | |
| CN105061358A (zh) | 甲基锍氯化物结晶水合物 | |
| DE2722162A1 (de) | Verfahren zur herstellung von phosphonigen saeuren | |
| US4061733A (en) | Veterinary compositions for inducing estrus in animals and method | |
| DE69313640T2 (de) | Zink-tranexamat derivat | |
| CA1077502A (en) | Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) compositions thereof methods of making and using | |
| DE2159363A1 (de) | Antimikrobielle mittel | |
| FI71319B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbart vicaminsackarinat | |
| HU198480B (en) | Process for producing furaltadone-mesylate salt and pharmaceutical compositions comprising this salt | |
| JP2018515454A (ja) | 尿酸輸送体阻害剤のナトリウム塩およびその結晶形 | |
| TW202115091A (zh) | 喹啉類似物之結晶型及其鹽類、組合物、及彼等之使用方法 | |
| RU2126402C1 (ru) | Способ селективного получения 3/2 гидрата 7-[(7-(s)-амино-5-азаспиро [2,4] гептан- 5-ил]-8-хлор-6-фтор-1- [(1r, 2s)-2-фторциклопропил]-4-оксо-1,4-дегидрохинолин-3- карбоновой кислоты, безводная 7-[(7-(s)-амино-5-азаспиро [2,4] гептан-5-ил]-8-хлор-6- фтор-1- (1r, 2s)-2-фторциклопропил-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота и фармацевтическая композиция, обладающая антибактериальной активностью | |
| WO2022228363A1 (zh) | 一种组合物的医药用途 | |
| JPS5962584A (ja) | コクシジユ−ム症に対して活性なキナゾリノン誘導体 | |
| JPS6031831B2 (ja) | ７−置換−８−アミノメチル−イソフラボン誘導体の製造方法 | |
| SK152095A3 (en) | Crystalline (+) l-hydrogentartrate, preparation method thereof, pharmaceutical composition containing its and its use | |
| US4912138A (en) | Pharmaceutical preparation containing thiamphenicol for veterinary use | |
| US4001231A (en) | Process for making a methenamine salt of an optically active acid | |
| JPH0656840A (ja) | デポー製剤 | |
| JPS62294616A (ja) | 抗真菌用薬剤 | |
| US2877154A (en) | Anthelmintic compositions containing chlorine substituted amides and methods for using same | |
| EP0140492B1 (en) | L-arginine isoxicamate | |
| CH634546A5 (de) | Verfahren zur herstellung von komplexen verbindungen von aminodicarbonsaeuren mit magnesium und halogenen. | |
| SU1014469A3 (ru) | Способ получени 9-[3-(3,5-цис-диметилпиперазин)-пропил]-карбазола или его соли,или сольвата его соли |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |