HRP20171824T1 - (TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A - Google Patents
(TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A Download PDFInfo
- Publication number
- HRP20171824T1 HRP20171824T1 HRP20171824TT HRP20171824T HRP20171824T1 HR P20171824 T1 HRP20171824 T1 HR P20171824T1 HR P20171824T T HRP20171824T T HR P20171824TT HR P20171824 T HRP20171824 T HR P20171824T HR P20171824 T1 HRP20171824 T1 HR P20171824T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- tieno
- benzoxazepin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (9)
1. Spoj formule
[image]
,
ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je HCl sol.
3. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je tosilatna sol.
4. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s patentnim zahtjevom 1, ili njegovu farmaceutski prihvatljivu sol, u kombinaciji s najmanje jednom farmaceutski prihvatljivom podlogom, razrjeđivačem ili pomoćnom tvari.
5. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
6. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju nesanice.
7. Spoj namijenjen upotrebi u skladu s patentnim zahtjevom 6, ili njegova farmaceutski prihvatljiva sol, naznačen time što je za nesanicu karakterističan otežani početak spavanja ili održavanje spavanja ili oboje.
8. Spoj, naznačen time što je namijenjen upotrebi u skladu s bilo patentnim zahtjevom 6 ili 7 kod čovjeka.
9. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s patentnim zahtjevom 1, ili njegovu farmaceutski prihvatljivu sol, u kombinaciji s najmanje jednom farmaceutski prihvatljivom podlogom, pomoćnom tvari ili razrjeđivačem, te selektivnim inhibitorom povratnog unosa serotonin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528893P | 2011-08-30 | 2011-08-30 | |
| PCT/US2012/051833 WO2013032804A1 (en) | 2011-08-30 | 2012-08-22 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
| EP12756856.6A EP2751115B1 (en) | 2011-08-30 | 2012-08-22 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171824T1 true HRP20171824T1 (hr) | 2017-12-29 |
Family
ID=46829875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171824TT HRP20171824T1 (hr) | 2011-08-30 | 2012-08-22 | (TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9512140B2 (hr) |
| EP (1) | EP2751115B1 (hr) |
| JP (1) | JP6042436B2 (hr) |
| KR (1) | KR101596607B1 (hr) |
| CN (1) | CN103958523B (hr) |
| AU (1) | AU2012300451B2 (hr) |
| BR (1) | BR112014004557A2 (hr) |
| CA (1) | CA2843514C (hr) |
| DK (1) | DK2751115T3 (hr) |
| EA (1) | EA024248B1 (hr) |
| ES (1) | ES2650225T3 (hr) |
| HR (1) | HRP20171824T1 (hr) |
| HU (1) | HUE034845T2 (hr) |
| LT (1) | LT2751115T (hr) |
| MX (1) | MX350419B (hr) |
| NO (1) | NO2776955T3 (hr) |
| PL (1) | PL2751115T3 (hr) |
| PT (1) | PT2751115T (hr) |
| RS (1) | RS56537B1 (hr) |
| SI (1) | SI2751115T1 (hr) |
| WO (1) | WO2013032804A1 (hr) |
| ZA (1) | ZA201400874B (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012283035B2 (en) * | 2011-07-08 | 2015-07-30 | Eli Lilly & Company | (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists |
| PL2943498T3 (pl) | 2013-01-14 | 2018-01-31 | Lilly Co Eli | Związki (tieno[2,3-b][1,5]benzoksazepin-4-ylo)piperazyn-1-ylowe jako odwrotni agoniści h1 / antagoniści 5-ht2a o podwójnej aktywności |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| WO2018234488A1 (en) | 2017-06-23 | 2018-12-27 | Basf Se | Substituted cyclopropyl derivatives |
| WO2019185413A1 (en) | 2018-03-27 | 2019-10-03 | Basf Se | Pesticidal substituted cyclopropyl derivatives |
| PL3898602T3 (pl) | 2018-12-21 | 2023-10-23 | Ogeda N.V. | Synteza 3-metylo-1,2,4-tiadiazolo-5-karbohydrazydu lub jego metylo-d3 deuterowanej postaci |
| MX2022004736A (es) * | 2019-10-21 | 2022-07-27 | Alairion Inc | Derivados de acido 3-(4-(11h-dibenzo [b, e] [1, 4] azepin-6-il)piperazin-1-il)- y 3-(4- dibenzo [b, f] [1, 4] oxazepin/tiazepin/diazepin-11-il)piperazin-1-il)propanoico como moduladores de los receptores h1 y 5-ht2a para el tratamiento de los trastornos del sue?o. |
| EP4043444A1 (en) | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
| IL304983A (en) | 2021-02-11 | 2023-10-01 | Basf Se | Isoxazoline histories are transmuted |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7395251B2 (en) * | 2005-07-01 | 2008-07-01 | International Business Machines Corporation | Neural networks for prediction and control |
| US7807828B2 (en) * | 2005-08-11 | 2010-10-05 | Hypnion, Inc. | Olanzapine analogs and methods of use thereof |
-
2012
- 2012-08-22 SI SI201231078T patent/SI2751115T1/sl unknown
- 2012-08-22 KR KR1020147004807A patent/KR101596607B1/ko not_active Expired - Fee Related
- 2012-08-22 EP EP12756856.6A patent/EP2751115B1/en active Active
- 2012-08-22 RS RS20171126A patent/RS56537B1/sr unknown
- 2012-08-22 JP JP2014528453A patent/JP6042436B2/ja not_active Expired - Fee Related
- 2012-08-22 PT PT127568566T patent/PT2751115T/pt unknown
- 2012-08-22 BR BR112014004557A patent/BR112014004557A2/pt not_active IP Right Cessation
- 2012-08-22 US US14/131,695 patent/US9512140B2/en not_active Expired - Fee Related
- 2012-08-22 HR HRP20171824TT patent/HRP20171824T1/hr unknown
- 2012-08-22 PL PL12756856T patent/PL2751115T3/pl unknown
- 2012-08-22 ES ES12756856.6T patent/ES2650225T3/es active Active
- 2012-08-22 DK DK12756856.6T patent/DK2751115T3/en active
- 2012-08-22 HU HUE12756856A patent/HUE034845T2/en unknown
- 2012-08-22 LT LTEP12756856.6T patent/LT2751115T/lt unknown
- 2012-08-22 AU AU2012300451A patent/AU2012300451B2/en not_active Ceased
- 2012-08-22 WO PCT/US2012/051833 patent/WO2013032804A1/en not_active Ceased
- 2012-08-22 EA EA201490332A patent/EA024248B1/ru not_active IP Right Cessation
- 2012-08-22 CN CN201280040793.9A patent/CN103958523B/zh not_active Expired - Fee Related
- 2012-08-22 CA CA2843514A patent/CA2843514C/en not_active Expired - Fee Related
- 2012-08-22 MX MX2014002473A patent/MX350419B/es active IP Right Grant
- 2012-11-09 NO NO12848689A patent/NO2776955T3/no unknown
-
2014
- 2014-02-05 ZA ZA2014/00874A patent/ZA201400874B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA024248B1 (ru) | 2016-08-31 |
| RS56537B1 (sr) | 2018-02-28 |
| BR112014004557A2 (pt) | 2017-05-30 |
| DK2751115T3 (en) | 2017-10-23 |
| US20140171411A1 (en) | 2014-06-19 |
| EP2751115A1 (en) | 2014-07-09 |
| CN103958523B (zh) | 2016-07-27 |
| HUE034845T2 (en) | 2018-03-28 |
| AU2012300451B2 (en) | 2016-10-13 |
| SI2751115T1 (sl) | 2017-11-30 |
| EP2751115B1 (en) | 2017-09-20 |
| JP2014525440A (ja) | 2014-09-29 |
| MX2014002473A (es) | 2016-09-26 |
| JP6042436B2 (ja) | 2016-12-14 |
| CN103958523A (zh) | 2014-07-30 |
| MX350419B (es) | 2017-09-05 |
| WO2013032804A1 (en) | 2013-03-07 |
| CA2843514C (en) | 2017-01-10 |
| ES2650225T3 (es) | 2018-01-17 |
| LT2751115T (lt) | 2017-12-27 |
| AU2012300451A1 (en) | 2014-01-30 |
| PT2751115T (pt) | 2017-12-20 |
| KR20140051355A (ko) | 2014-04-30 |
| ZA201400874B (en) | 2015-10-28 |
| CA2843514A1 (en) | 2013-03-07 |
| EA201490332A1 (ru) | 2014-06-30 |
| KR101596607B1 (ko) | 2016-02-22 |
| NO2776955T3 (hr) | 2018-06-02 |
| PL2751115T3 (pl) | 2018-02-28 |
| US9512140B2 (en) | 2016-12-06 |
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