[go: up one dir, main page]

HRP20170246T1 - Režim doziranja za selektivni agonist s1p1-receptora - Google Patents

Režim doziranja za selektivni agonist s1p1-receptora

Info

Publication number
HRP20170246T1
HRP20170246T1 HRP20170246TT HRP20170246T HRP20170246T1 HR P20170246 T1 HRP20170246 T1 HR P20170246T1 HR P20170246T T HRP20170246T T HR P20170246TT HR P20170246 T HRP20170246 T HR P20170246T HR P20170246 T1 HRP20170246 T1 HR P20170246T1
Authority
HR
Croatia
Prior art keywords
selective
receptor agonist
dosage mode
dosage
mode
Prior art date
Application number
HRP20170246TT
Other languages
English (en)
Inventor
Patrick Brossard
Jasper Dingemanse
Oliver Nayler
Michael Scherz
Beat Steiner
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40786618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20170246(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of HRP20170246T1 publication Critical patent/HRP20170246T1/hr
Publication of HRP20170246T4 publication Critical patent/HRP20170246T4/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20170246TT 2008-03-17 2009-03-12 Režim doziranja za selektivni agonist s1p1-receptora HRP20170246T4 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008050995 2008-03-17
EP09721703.8A EP2278960B2 (en) 2008-03-17 2009-03-12 Dosing regimen for a selective sip1 receptor agonist
PCT/IB2009/051030 WO2009115954A1 (en) 2008-03-17 2009-03-12 Dosing regimen for a selective s1p1 receptor agonist

Publications (2)

Publication Number Publication Date
HRP20170246T1 true HRP20170246T1 (hr) 2017-04-07
HRP20170246T4 HRP20170246T4 (hr) 2020-02-07

Family

ID=40786618

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20170246TT HRP20170246T4 (hr) 2008-03-17 2009-03-12 Režim doziranja za selektivni agonist s1p1-receptora

Country Status (27)

Country Link
US (6) US8785484B2 (hr)
EP (1) EP2278960B2 (hr)
JP (2) JP4846063B2 (hr)
KR (3) KR20100134032A (hr)
CN (2) CN101980704A (hr)
AR (1) AR070842A1 (hr)
AU (1) AU2009227629B2 (hr)
BR (1) BRPI0909625B1 (hr)
CA (1) CA2716448A1 (hr)
CY (1) CY1118648T1 (hr)
DK (1) DK2278960T4 (hr)
ES (1) ES2617628T5 (hr)
HR (1) HRP20170246T4 (hr)
HU (1) HUE033168T2 (hr)
IL (1) IL208154A (hr)
LT (1) LT2278960T (hr)
MA (1) MA32233B1 (hr)
MX (1) MX2010009853A (hr)
MY (1) MY177360A (hr)
NZ (1) NZ588505A (hr)
PL (1) PL2278960T5 (hr)
PT (1) PT2278960T (hr)
RU (1) RU2519660C2 (hr)
SI (1) SI2278960T2 (hr)
TW (1) TWI434688B (hr)
WO (1) WO2009115954A1 (hr)
ZA (1) ZA201007367B (hr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
DK1689726T3 (da) 2003-11-21 2010-12-06 Actelion Pharmaceuticals Ltd 5-(benz-(z)-yliden)-thiazolidin-4-on-derivater som immunsuppresserende midler
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
MX2009005048A (es) * 2006-11-23 2009-05-25 Actelion Pharmaceuticals Ltd Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
WO2009115954A1 (en) * 2008-03-17 2009-09-24 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
RS59857B1 (sr) * 2008-12-22 2020-02-28 Novartis Ag Režim doziranja agonista s1p receptora
US8853419B2 (en) 2010-01-27 2014-10-07 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
AU2011249789B2 (en) * 2010-05-06 2015-03-19 Novartis Ag Dosage regimen of diaryl sulfide derivatives
ES2751920T3 (es) 2011-01-07 2020-04-02 Novartis Ag Formulaciones inmunosupresoras
US9340518B2 (en) 2012-08-17 2016-05-17 Actelion Pharmaceuticals Ltd. Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process
EP3062792A1 (en) 2013-11-01 2016-09-07 Celgene International II Sarl Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith
KR20230147768A (ko) * 2014-12-11 2023-10-23 액테리온 파마슈티칼 리미티드 선택적 s1p1 수용체 효능제에 대한 투약 섭생
MA41139A (fr) * 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
EP4445956A3 (en) * 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
CA2973540A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
HUE060476T2 (hu) 2015-06-22 2023-03-28 Arena Pharm Inc (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
AU2018222747A1 (en) * 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
CN112601516A (zh) 2018-06-06 2021-04-02 艾尼纳制药公司 治疗与s1p1受体相关的病况的方法
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
AU2020372647A1 (en) 2019-10-31 2022-06-16 Idorsia Pharmaceuticals Ltd Combination of a CXCR7 antagonist with an S1P1 receptor modulator
WO2023061935A1 (en) 2021-10-11 2023-04-20 Actelion Pharmaceuticals Ltd Methods of treating multiple sclerosis
WO2023062511A1 (en) 2021-10-11 2023-04-20 Actelion Pharmaceuticals Ltd Methods of treating multiple sclerosis
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2126658T3 (es) 1992-10-21 1999-04-01 Yoshitomi Pharmaceutical Compuesto de 2-amino-1,3-propanodiol e inmunosupresor.
AU705320B2 (en) 1995-12-28 1999-05-20 Welfide Corporation 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof for use in the preparation of a non-oral medicament, and for treatment of diseases and disorders
US6476004B1 (en) 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
JPH11209277A (ja) * 1998-01-19 1999-08-03 Yoshitomi Pharmaceut Ind Ltd 医薬組成物
ES2317663T3 (es) 1997-02-27 2009-04-16 Novartis Ag Composicion farmaceutica que comprende 2-amino-2-(2-(4-octilfenil)etil)propano-1,3-diol, una lecitina y un sacarido.
WO1998052944A1 (en) 1997-05-19 1998-11-26 Sugen, Inc. Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
JPH1180026A (ja) 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
WO2002012545A2 (en) * 2000-08-03 2002-02-14 Cytovia, Inc. Method of identifying immunosuppressive agents
IL157946A0 (en) 2001-04-02 2004-03-28 Genentech Inc Combination therapy
ES2261655T3 (es) 2001-04-02 2006-11-16 Astrazeneca Ab Composicion farmaceutica solida que comprende 4'-ciano-trifluoro-3-(4-fluorofenilsulfonil)-2-hidroxi-2-metilpropiono-m-toluiduro y pvp.
US6495025B2 (en) 2001-04-20 2002-12-17 Aerovironment, Inc. Electrochemical oxygen generator and process
CN101417120A (zh) * 2001-05-16 2009-04-29 尼古拉斯·P·普洛特尼科夫 诱导持续免疫应答的方法
ATE424893T1 (de) 2001-06-08 2009-03-15 Novartis Pharma Gmbh Behandlung und vorbeugung von insulin- produzierende zelltransplantatabstossung
DE60235900D1 (de) 2001-09-27 2010-05-20 Kyorin Seiyaku Kk Osuppressivum
CN1329372C (zh) 2001-09-27 2007-08-01 杏林制药株式会社 二芳基硫醚衍生物及其加成盐和免疫抑制剂
AU2003216054B2 (en) 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
CA2472715A1 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
GB0217152D0 (en) * 2002-07-24 2002-09-04 Novartis Ag Organic compounds
PL408347A1 (pl) 2002-09-24 2014-08-18 Novartis Ag Kombinacja, zastosowanie kombinacji oraz zastosowanie agonisty receptora S1P
EP1613288B1 (en) 2003-04-08 2008-11-19 Novartis AG Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
DK1689726T3 (da) * 2003-11-21 2010-12-06 Actelion Pharmaceuticals Ltd 5-(benz-(z)-yliden)-thiazolidin-4-on-derivater som immunsuppresserende midler
USRE43833E1 (en) * 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
WO2005123677A1 (en) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
WO2006041015A1 (ja) 2004-10-12 2006-04-20 Kyorin Pharmaceutical Co., Ltd. アミノアルコール誘導体とその付加塩及び免疫抑制剤
US20060090658A1 (en) * 2004-11-01 2006-05-04 Michael Phillips Tissue marking system
KR20130041385A (ko) 2004-11-29 2013-04-24 노파르티스 아게 Ｓ１ｐ 수용체 효능제의 투여 용법
PL1863474T3 (pl) 2005-03-23 2009-04-30 Actelion Pharmaceuticals Ltd Nowe pochodne tiofenu jako agoniści receptora 1 1-fosforanu sfingozyny
SI1863787T1 (sl) 2005-03-23 2011-10-28 Actelion Pharmaceuticals Ltd Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji
WO2006100635A2 (en) 2005-03-23 2006-09-28 Actelion Pharmaceuticals Ltd Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists
WO2006137019A1 (en) 2005-06-24 2006-12-28 Actelion Pharmaceuticals Ltd Novel thiophene derivatives
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
KR20080092385A (ko) 2006-01-24 2008-10-15 액테리온 파마슈티칼 리미티드 신규한 피리딘 유도체
US7879821B2 (en) * 2006-01-26 2011-02-01 University Of Medicine And Dentistry Of New Jersey Method for modulating inflammatory responses by altering plasma lipid levels
MX2009002233A (es) 2006-09-07 2009-03-16 Actelion Pharmaceuticals Ltd Derivados de piridin-4-il como agentes inmunomoduladores.
TWI408139B (zh) 2006-09-07 2013-09-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
SI2069335T1 (sl) 2006-09-08 2013-04-30 Actelion Pharmaceuticals Ltd. Derivati piridin-3-ila kot imunomodulacijska sredstva
CN101522645B (zh) 2006-09-21 2013-01-09 埃科特莱茵药品有限公司 苯衍生物及其免疫调节剂的用途
US8912340B2 (en) * 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
MX2009005048A (es) * 2006-11-23 2009-05-25 Actelion Pharmaceuticals Ltd Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
BRPI0808789A2 (pt) 2007-03-16 2014-08-12 Actelion Pharmaceuticals Ltd Compostos e composição farmacêutica de derivados aminopiridina e uso destes
BRPI0815190A2 (pt) 2007-08-17 2015-03-31 Actelion Pharmaceuticals Ltd Composto derivado de piridina, composição farmacêutica que o compreende e uso do mesmo
CA2925175A1 (en) 2007-10-12 2009-04-16 Novartis Ag Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
WO2009115954A1 (en) 2008-03-17 2009-09-24 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist
ES2583630T3 (es) * 2008-08-27 2016-09-21 Arena Pharmaceuticals, Inc. Derivados de ácido tricíclico sustituido como agonistas del receptor S1P1 útiles en el tratamiento de trastornos autoinmunes e inflamatorios
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
WO2010072703A1 (en) * 2008-12-22 2010-07-01 Novartis Ag Dosage regimen of an s1p receptor agonist
RS59857B1 (sr) 2008-12-22 2020-02-28 Novartis Ag Režim doziranja agonista s1p receptora
JP5416600B2 (ja) 2010-01-22 2014-02-12 株式会社日立ハイテクノロジーズ 欠陥検査装置およびその方法
US9340518B2 (en) 2012-08-17 2016-05-17 Actelion Pharmaceuticals Ltd. Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process
KR20230147768A (ko) 2014-12-11 2023-10-23 액테리온 파마슈티칼 리미티드 선택적 s1p1 수용체 효능제에 대한 투약 섭생
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1

Also Published As

Publication number Publication date
US10660880B2 (en) 2020-05-26
US20140316140A1 (en) 2014-10-23
CY1118648T1 (el) 2017-07-12
CN101980704A (zh) 2011-02-23
PT2278960T (pt) 2017-03-09
US20150265580A1 (en) 2015-09-24
IL208154A0 (en) 2010-12-30
AU2009227629A1 (en) 2009-09-24
JP2012025756A (ja) 2012-02-09
AR070842A1 (es) 2010-05-05
US20140303217A1 (en) 2014-10-09
CN104800208A (zh) 2015-07-29
MA32233B1 (fr) 2011-04-01
WO2009115954A1 (en) 2009-09-24
DK2278960T4 (da) 2020-01-27
US20110021581A1 (en) 2011-01-27
KR20150023902A (ko) 2015-03-05
US10251867B2 (en) 2019-04-09
LT2278960T (lt) 2017-02-10
KR101653071B1 (ko) 2016-08-31
EP2278960B2 (en) 2019-11-13
US8785484B2 (en) 2014-07-22
KR20140035538A (ko) 2014-03-21
ES2617628T3 (es) 2017-06-19
US20140315964A1 (en) 2014-10-23
CA2716448A1 (en) 2009-09-24
ES2617628T5 (es) 2020-06-01
JP2011514379A (ja) 2011-05-06
JP4938905B2 (ja) 2012-05-23
PL2278960T3 (pl) 2017-06-30
SI2278960T1 (sl) 2017-05-31
RU2519660C2 (ru) 2014-06-20
ZA201007367B (en) 2016-06-29
JP4846063B2 (ja) 2011-12-28
MY177360A (en) 2020-09-14
KR101718639B1 (ko) 2017-03-21
TW200942235A (en) 2009-10-16
SI2278960T2 (sl) 2020-02-28
AU2009227629B2 (en) 2014-09-04
HRP20170246T4 (hr) 2020-02-07
PL2278960T5 (pl) 2020-06-29
DK2278960T3 (en) 2017-01-16
BRPI0909625A2 (pt) 2018-04-10
BRPI0909625B1 (pt) 2021-09-08
NZ588505A (en) 2012-09-28
MX2010009853A (es) 2010-09-30
US20210401811A1 (en) 2021-12-30
TWI434688B (zh) 2014-04-21
HUE033168T2 (en) 2017-11-28
IL208154A (en) 2015-09-24
EP2278960B1 (en) 2016-11-30
KR20100134032A (ko) 2010-12-22
RU2010141579A (ru) 2012-04-27
EP2278960A1 (en) 2011-02-02

Similar Documents

Publication Publication Date Title
HRP20170246T1 (hr) Režim doziranja za selektivni agonist s1p1-receptora
LTPA2020513I1 (lt) S1P receptoriaus agonisto dozavimas
CY2020023I1 (el) Αναστολεiς βητα-λακταμασων
CY2020036I1 (el) Δοσολογικο σχημα για εναν αγωνιστη του υποδοχεα s1p
BRPI0810374A2 (pt) Inibidores específicos do pdgfrbeta
BRPI0918760A2 (pt) compostos morfinanos
DK2308877T3 (da) Imidazopyridin-2-on-derivater
DK2340021T3 (da) Substituerede pyrrolidin-2-carboxamider
EP2300145A4 (en) MICROENCAPSULATION ADMINISTRATION SYSTEM
BRPI0914781A2 (pt) Microbiocidas
DK2200752T3 (da) Doseringsindretning
BRPI0918564A2 (pt) inibidores
ATE546453T1 (de) Nalmefen-hydrochlorid-dihydrat
DE112009000578A5 (de) Reibahle
DK2275414T3 (da) Cyclopentylacrylamidderivat
BRPI0810926A2 (pt) Antagonista de crig
DK2799428T3 (da) Glucagon-antagonister
ATE545635T1 (de) Substituierte n-oxidpyrazinderivate
NO2019028I1 (no) Cabergoline
DK2364185T3 (da) Disubstituerede phthalazin-hedgehog-pathway-antagonister
BRPI0907963A2 (pt) Derivados de indazola
BRPI0911199A2 (pt) microbiocidas
ATE534634T1 (de) 2-phenyl-4-cyclopropyl-pyrimidinderivate
BRPI0908008A2 (pt) Farmacóforo dual - pde4-antagonistas muscarínicos
DK2342060T3 (da) Doseringsindretning