HRP20090453T1 - Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora - Google Patents
Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora Download PDFInfo
- Publication number
- HRP20090453T1 HRP20090453T1 HR20090453T HRP20090453T HRP20090453T1 HR P20090453 T1 HRP20090453 T1 HR P20090453T1 HR 20090453 T HR20090453 T HR 20090453T HR P20090453 T HRP20090453 T HR P20090453T HR P20090453 T1 HRP20090453 T1 HR P20090453T1
- Authority
- HR
- Croatia
- Prior art keywords
- benzoimidazol
- phenyl
- disorder
- pyridin
- ylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67064705P | 2005-04-13 | 2005-04-13 | |
DKPA200500530 | 2005-04-13 | ||
PCT/EP2006/061417 WO2006108800A1 (en) | 2005-04-13 | 2006-04-07 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090453T1 true HRP20090453T1 (hr) | 2009-10-31 |
Family
ID=36658703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090453T HRP20090453T1 (hr) | 2005-04-13 | 2006-04-07 | Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora |
Country Status (19)
Country | Link |
---|---|
US (1) | US7851490B2 (ko) |
EP (1) | EP1877052B1 (ko) |
JP (1) | JP2008535891A (ko) |
KR (1) | KR20070119691A (ko) |
AU (1) | AU2006233894A1 (ko) |
CA (1) | CA2604516A1 (ko) |
CO (1) | CO6241194A2 (ko) |
DE (1) | DE602006007976D1 (ko) |
DK (1) | DK1877052T3 (ko) |
ES (1) | ES2330468T3 (ko) |
HR (1) | HRP20090453T1 (ko) |
IL (1) | IL185371A0 (ko) |
MX (1) | MX2007012624A (ko) |
NO (1) | NO20075793L (ko) |
NZ (1) | NZ560939A (ko) |
PL (1) | PL1877052T3 (ko) |
PT (1) | PT1877052E (ko) |
RU (1) | RU2405779C2 (ko) |
WO (1) | WO2006108800A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080077620A (ko) * | 2005-12-05 | 2008-08-25 | 뉴로서치 에이/에스 | 벤즈이미다졸 및 gabaa 수용체 복합체를 조절하기위한 이의 용도 |
TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
WO2010055124A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
WO2010055125A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
WO2010055126A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
RU2452486C1 (ru) * | 2011-04-13 | 2012-06-10 | Общество с ограниченной ответственностью "Лечебно-реабилитационный научный центр "Феникс" | Способ фармакотерапии панического расстройства |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
KR100297445B1 (ko) | 1995-04-21 | 2001-10-25 | 페더 벨링 | 벤즈이미다졸화합물및감마-아미노부틸산수용체복합체의조절인자로서의그들의용도 |
AU726447B2 (en) * | 1996-10-21 | 2000-11-09 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators |
EP1023286A1 (en) * | 1997-10-10 | 2000-08-02 | Neurosearch A/S | Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use |
CA2373921A1 (en) * | 1999-06-22 | 2000-12-28 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
WO2002050057A1 (en) | 2000-12-20 | 2002-06-27 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
US7335777B2 (en) | 2003-04-03 | 2008-02-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
US20060069135A1 (en) * | 2003-04-03 | 2006-03-30 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex |
AP2006003549A0 (en) * | 2003-08-21 | 2006-04-30 | Osi Pharm Inc | N-substituted benzimidazolyl C-kit inhibitors. |
EP1678144A1 (en) | 2003-10-23 | 2006-07-12 | Akzo Nobel N.V. | 1,5,7-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-a RECEPTOR COMPLEX |
US7419995B2 (en) * | 2004-12-01 | 2008-09-02 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library |
TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
-
2006
- 2006-04-07 NZ NZ560939A patent/NZ560939A/en not_active IP Right Cessation
- 2006-04-07 CA CA002604516A patent/CA2604516A1/en not_active Abandoned
- 2006-04-07 HR HR20090453T patent/HRP20090453T1/hr unknown
- 2006-04-07 AU AU2006233894A patent/AU2006233894A1/en not_active Abandoned
- 2006-04-07 MX MX2007012624A patent/MX2007012624A/es active IP Right Grant
- 2006-04-07 RU RU2007137096/04A patent/RU2405779C2/ru not_active IP Right Cessation
- 2006-04-07 PL PL06725630T patent/PL1877052T3/pl unknown
- 2006-04-07 KR KR1020077023521A patent/KR20070119691A/ko not_active Withdrawn
- 2006-04-07 ES ES06725630T patent/ES2330468T3/es active Active
- 2006-04-07 JP JP2008505868A patent/JP2008535891A/ja not_active Abandoned
- 2006-04-07 PT PT06725630T patent/PT1877052E/pt unknown
- 2006-04-07 EP EP06725630A patent/EP1877052B1/en active Active
- 2006-04-07 DK DK06725630T patent/DK1877052T3/da active
- 2006-04-07 US US11/887,780 patent/US7851490B2/en not_active Expired - Fee Related
- 2006-04-07 WO PCT/EP2006/061417 patent/WO2006108800A1/en active Application Filing
- 2006-04-07 DE DE602006007976T patent/DE602006007976D1/de active Active
-
2007
- 2007-08-20 IL IL185371A patent/IL185371A0/en unknown
- 2007-10-09 CO CO07105966A patent/CO6241194A2/es not_active Application Discontinuation
- 2007-11-12 NO NO20075793A patent/NO20075793L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2007012624A (es) | 2008-01-11 |
RU2007137096A (ru) | 2009-05-20 |
CO6241194A2 (es) | 2011-01-20 |
NO20075793L (no) | 2008-01-14 |
US20090036493A1 (en) | 2009-02-05 |
EP1877052A1 (en) | 2008-01-16 |
PT1877052E (pt) | 2009-08-25 |
PL1877052T3 (pl) | 2010-01-29 |
DE602006007976D1 (de) | 2009-09-03 |
NZ560939A (en) | 2010-07-30 |
ES2330468T3 (es) | 2009-12-10 |
JP2008535891A (ja) | 2008-09-04 |
WO2006108800A1 (en) | 2006-10-19 |
KR20070119691A (ko) | 2007-12-20 |
AU2006233894A1 (en) | 2006-10-19 |
IL185371A0 (en) | 2008-02-09 |
CA2604516A1 (en) | 2006-10-19 |
DK1877052T3 (da) | 2009-10-12 |
EP1877052B1 (en) | 2009-07-22 |
US7851490B2 (en) | 2010-12-14 |
RU2405779C2 (ru) | 2010-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20090453T1 (hr) | Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora | |
JP2009530353A5 (ko) | ||
JP2011528372A (ja) | α7ニコチン性アセチルコリンレセプターインヒビター | |
JP2016528201A5 (ko) | ||
JP2017039755A5 (ko) | ||
JP6321825B2 (ja) | 神経形成を刺激することができるn−フェニル−ラクタム誘導体及び神経障害の処置におけるそれらの使用 | |
EP2604602A4 (en) | HETEROARYL PYRAZOLE DERIVATIVE | |
JP2010523654A (ja) | 複素環化合物およびその使用方法 | |
WO2007085556A3 (en) | Use of 4-imidazole derivatives for cns disorders | |
JP2011524850A5 (ko) | ||
RU2009103307A (ru) | ПРОИЗВОДНЫЕ ИМИДАЗО[1, 2-a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ | |
MX2012007409A (es) | Derivados de benzamida sustituidos. | |
JP2019537581A5 (ko) | ||
JP2009511547A5 (ko) | ||
RU2017104264A (ru) | 2-окса-5-азабицикло[2.2.1]гептан-3-ильные производные | |
HRP20230290T1 (hr) | Derivati triazina za liječenje bolesti u vezi sa neurotrofinima | |
JP2017535559A (ja) | Gpr139のモジュレーターとしての4−オキソ−3,4−ジヒドロ−1,2,3−ベンゾトリアジン | |
PH12013502263A1 (en) | Substituted benzamide derivatives | |
RU2011103759A (ru) | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора | |
HRP20151003T1 (hr) | Novi spojevi kao ligandi receptora histamina h3 | |
JP2019537592A5 (ko) | ||
JP2020503302A5 (ko) | ||
NZ595627A (en) | Substituted 2-mercapto-3-aminopyridines as kcnq2/3 modulators | |
ES3032458T3 (en) | Crystalline form of the hydrochloride salt of 2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol | |
JP2004524279A5 (ko) |