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HRP20050903A2 - Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke - Google Patents

Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke

Info

Publication number
HRP20050903A2
HRP20050903A2 HR20050903A HRP20050903A HRP20050903A2 HR P20050903 A2 HRP20050903 A2 HR P20050903A2 HR 20050903 A HR20050903 A HR 20050903A HR P20050903 A HRP20050903 A HR P20050903A HR P20050903 A2 HRP20050903 A2 HR P20050903A2
Authority
HR
Croatia
Prior art keywords
plasminogen
intravenous injection
treating cerebral
cerebral stroke
neurotoxic
Prior art date
Application number
HR20050903A
Other languages
Croatian (hr)
Inventor
Söhngen Mariola
Söhngen Wolfgang
Schleuning Wolf-Dieter
Medcalf Robert
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2003/004729 external-priority patent/WO2004096267A1/en
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Publication of HRP20050903A2 publication Critical patent/HRP20050903A2/en
Publication of HRP20050903B1 publication Critical patent/HRP20050903B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Izum se odnosi na upotrebu ne-neurotoksičnih faktora aktiviranja plazminogena, npr. iz Desmodus rotundus (DSPA) ili genetski modificiranih faktora aktiviranja plazminogena, naročito ljudskog porijekla, za proizvodnju lijeka za injekcije za terapijsko liječenje kapi kod ljudi.The invention relates to the use of non-neurotoxic plasminogen activating factors, e.g. from Desmodus rotundus (DSPA) or genetically modified plasminogen activating factors, in particular of human origin, for the manufacture of a medicament for injection for the therapeutic treatment of drops in humans.

HRP20050903AA 2003-05-02 2005-10-17 Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke HRP20050903B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP03/04608 2003-05-02
PCT/EP2003/004729 WO2004096267A1 (en) 2003-05-02 2003-05-06 Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
PCT/EP2004/004626 WO2004096268A2 (en) 2003-05-02 2004-04-30 Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke

Publications (2)

Publication Number Publication Date
HRP20050903A2 true HRP20050903A2 (en) 2006-08-31
HRP20050903B1 HRP20050903B1 (en) 2013-11-22

Family

ID=35610451

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050903AA HRP20050903B1 (en) 2003-05-02 2005-10-17 Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke

Country Status (10)

Country Link
EP (1) EP1622639B1 (en)
JP (1) JP2006525270A (en)
KR (1) KR101212631B1 (en)
BR (1) BRPI0409865A (en)
CA (1) CA2524573A1 (en)
HR (1) HRP20050903B1 (en)
NO (1) NO337485B1 (en)
NZ (1) NZ543367A (en)
PL (1) PL1622639T3 (en)
WO (1) WO2004096268A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
DE10342518A1 (en) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen activators with reduced lysine binding capacity
CN104840455A (en) 2005-02-24 2015-08-19 扩散药品有限公司 Trans carotenoids, their synthesis, formulation and uses
EP1897554A1 (en) * 2006-08-25 2008-03-12 PAION Deutschland GmbH Method for the manufacture of a medicament for treating hemorrhagic stroke
WO2008022801A1 (en) * 2006-08-25 2008-02-28 Paion Deutschland Gmbh Method for the manufacture of a medicament for treating hemorrhagic stroke
US8293804B2 (en) 2007-04-13 2012-10-23 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
CA2765169C (en) 2009-06-10 2019-06-18 Nono Inc. Model systems and treatment regimes for treatment of neurological disease
EP2445339B1 (en) * 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
JP5823672B2 (en) * 2009-07-27 2015-11-25 国立大学法人 新潟大学 Pharmaceutical composition for treating cerebral infarction comprising receptor signaling inhibitor
JP5823671B2 (en) * 2009-07-27 2015-11-25 国立大学法人 新潟大学 Pharmaceutical composition for the treatment of cerebral infarction comprising immunological preparation
US8652476B2 (en) 2009-07-27 2014-02-18 Niigata University Pharmaceutical composition for treating ischemic events
CA2801292C (en) 2010-06-02 2019-01-22 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
EP4052721A1 (en) 2011-06-24 2022-09-07 NoNO Inc. Combination therapy for ischemia
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
NL8902454A (en) * 1989-10-03 1991-05-01 Stichting Centraal Lab MUTANTS OF THE HUMANE PLASMINOGENIC ACTIVATOR INHIBITOR 1 (PAI-1), THEIR PREPARATION AND USE, AND RECOMBINANT POLYNUCLEOTIDES INCLUDING GENETIC INFORMATION CODING FOR THESE MUTANTS.
DE10153601A1 (en) * 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke

Also Published As

Publication number Publication date
NZ543367A (en) 2010-06-25
HRP20050903B1 (en) 2013-11-22
NO337485B1 (en) 2016-04-25
NO20055692D0 (en) 2005-12-01
EP1622639B1 (en) 2013-01-16
CA2524573A1 (en) 2004-11-11
BRPI0409865A (en) 2006-05-16
NO20055692L (en) 2006-01-30
KR20060020616A (en) 2006-03-06
WO2004096268A3 (en) 2005-04-21
EP1622639A2 (en) 2006-02-08
JP2006525270A (en) 2006-11-09
KR101212631B1 (en) 2012-12-14
PL1622639T3 (en) 2013-06-28
WO2004096268A2 (en) 2004-11-11

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Legal Events

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Owner name: H. LUNDBECK A/S, DK

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20170306

Year of fee payment: 14

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Effective date: 20180430