HRP20040988A2 - Pyrrolo-triazine aniline compounds useful as kinas - Google Patents

Pyrrolo-triazine aniline compounds useful as kinas

Info

Publication number: HRP20040988A2
Authority: HR; Croatia
Prior art keywords: alkyl; optionally substituted; substituted; heteroaryl; phenyl
Prior art date: 2002-04-23

Application number

HR20040988A

Other languages

English (en)

Croatian (hr)

Inventor

Dyckman Alaric

Hynes John

Leftheris Katherina

Liu Chunjian

T. Wrobleski Stephen

Original Assignee

Bristol-Myers Squibb Company A Delaware (Usa) Corp

Oration

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-23

Filing date

2003-04-15

Publication date

2005-06-30

2003-04-15 Application filed by Bristol-Myers Squibb Company A Delaware (Usa) Corp, Oration filed Critical Bristol-Myers Squibb Company A Delaware (Usa) Corp

2005-06-30 Publication of HRP20040988A2 publication Critical patent/HRP20040988A2/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Neurology (AREA)
Immunology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)

HR20040988A 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinas HRP20040988A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37493802P	2002-04-23	2002-04-23
PCT/US2003/012426 WO2003090912A1 (en)	2002-04-23	2003-04-15	Pyrrolo-triazine aniline compounds useful as kinase inhibitors

Publications (1)

Publication Number	Publication Date
HRP20040988A2 true HRP20040988A2 (en)	2005-06-30

Family

ID=29270573

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040988A HRP20040988A2 (en)	2002-04-23	2003-04-15	Pyrrolo-triazine aniline compounds useful as kinas

Country Status (30)

Country	Link
US (5)	US7160883B2 (de)
EP (2)	EP1497019B1 (de)
JP (2)	JP4669225B2 (de)
KR (1)	KR101025675B1 (de)
CN (2)	CN102093363B (de)
AR (1)	AR039649A1 (de)
AU (1)	AU2003231034B2 (de)
BR (1)	BR0309669A (de)
CA (1)	CA2483164C (de)
DK (1)	DK1497019T3 (de)
ES (1)	ES2543711T3 (de)
GE (1)	GEP20074148B (de)
HR (1)	HRP20040988A2 (de)
HU (1)	HUE025353T2 (de)
IL (2)	IL164573A (de)
IS (1)	IS7505A (de)
MX (1)	MXPA04010379A (de)
MY (1)	MY132094A (de)
NO (1)	NO329503B1 (de)
NZ (1)	NZ536014A (de)
PE (1)	PE20040590A1 (de)
PL (1)	PL219736B1 (de)
PT (1)	PT1497019E (de)
RS (1)	RS92004A (de)
RU (1)	RU2375363C2 (de)
SI (1)	SI1497019T1 (de)
TW (1)	TWI312782B (de)
UA (1)	UA78562C2 (de)
WO (1)	WO2003090912A1 (de)
ZA (1)	ZA200408541B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6670357B2 (en) *	2000-11-17	2003-12-30	Bristol-Myers Squibb Company	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en)	2000-11-17	2005-03-15	Bristol-Myers Squibb Company	Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
UA78562C2 (en) *	2002-04-23	2007-04-10	Bristol Myers Squibb Co	Pyrrolo-triazine aniline compounds useful as kinase inhibitors
TW200400034A (en)	2002-05-20	2004-01-01	Bristol Myers Squibb Co	Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TW200401638A (en) *	2002-06-20	2004-02-01	Bristol Myers Squibb Co	Heterocyclic inhibitors of kinases
TWI329112B (en) *	2002-07-19	2010-08-21	Bristol Myers Squibb Co	Novel inhibitors of kinases
US6951859B2 (en) *	2002-08-02	2005-10-04	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
TW200420565A (en) *	2002-12-13	2004-10-16	Bristol Myers Squibb Co	C-6 modified indazolylpyrrolotriazines
MXPA05008183A (es) *	2003-02-05	2005-10-05	Bristol Myers Squibb Co	Proceso para preparar pirrolotriazina como inhibidores de cinasa.
WO2005030128A2 (en) *	2003-09-23	2005-04-07	Merck & Co., Inc.	Pyrazole modulators of metabotropic glutamate receptors
US7419978B2 (en) *	2003-10-22	2008-09-02	Bristol-Myers Squibb Company	Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
US7309708B2 (en) *	2003-11-20	2007-12-18	Birstol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2005058832A1 (en) *	2003-12-10	2005-06-30	Merck Patent Gmbh	Diacylhydrazine derivatives
US7102001B2 (en)	2003-12-12	2006-09-05	Bristol-Myers Squibb Company	Process for preparing pyrrolotriazine
KR100899245B1 (ko) *	2003-12-23	2009-05-26	노파르티스 아게	비시클릭 헤테로시클릭 ｐ-38 키나제 억제제
MY145634A (en)	2003-12-29	2012-03-15	Bristol Myers Squibb Co	Pyrrolotriazine compounds as kinase inhibitors
US7064203B2 (en)	2003-12-29	2006-06-20	Bristol Myers Squibb Company	Di-substituted pyrrolotriazine compounds
US7459562B2 (en) *	2004-04-23	2008-12-02	Bristol-Myers Squibb Company	Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) *	2004-04-26	2005-12-01	Bristol Myers Squibb Co	Bicyclic heterocycles as kinase inhibitors
US7102002B2 (en)	2004-06-16	2006-09-05	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US7439246B2 (en) *	2004-06-28	2008-10-21	Bristol-Myers Squibb Company	Fused heterocyclic kinase inhibitors
US7432373B2 (en) *	2004-06-28	2008-10-07	Bristol-Meyers Squibb Company	Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US20050288290A1 (en) *	2004-06-28	2005-12-29	Borzilleri Robert M	Fused heterocyclic kinase inhibitors
TW200600513A (en)	2004-06-30	2006-01-01	Bristol Myers Squibb Co	A method for preparing pyrrolotriazine compounds
US7253167B2 (en)	2004-06-30	2007-08-07	Bristol-Myers Squibb Company	Tricyclic-heteroaryl compounds useful as kinase inhibitors
US7102003B2 (en)	2004-07-01	2006-09-05	Bristol-Myers Squibb Company	Pyrrolotriazine compounds
US7504521B2 (en)	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
PE20060421A1 (es)	2004-08-12	2006-06-01	Bristol Myers Squibb Co	Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
US7151176B2 (en)	2004-10-21	2006-12-19	Bristol-Myers Squibb Company	Pyrrolotriazine compounds
ATE480542T1 (de) *	2004-10-26	2010-09-15	Novartis Ag	Pyrroloä1,2-düä1,2-4ütriazin als inhibitoren von c-jun-n-terminal-kinasen (jnk) und p-38-kinasen
US7534882B2 (en)	2005-04-06	2009-05-19	Bristol-Myers Squibb Company	Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
US20060235020A1 (en) *	2005-04-18	2006-10-19	Soojin Kim	Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
US7405213B2 (en) *	2005-07-01	2008-07-29	Bristol-Myers Squibb Company	Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7442700B2 (en) *	2005-07-01	2008-10-28	Bristol-Myers Squibb Company	Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7402582B2 (en) *	2005-07-01	2008-07-22	Bristol-Myers Squibb Company	Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7348325B2 (en) *	2005-11-30	2008-03-25	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US8063208B2 (en)	2006-02-16	2011-11-22	Bristol-Myers Squibb Company	Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
KR20080107408A (ko)	2006-03-07	2008-12-10	브리스톨-마이어스 스큅 컴퍼니	키나제 억제제로서 유용한 피롤로트리아진 아닐린 전구약물화합물
US7531539B2 (en) *	2006-08-09	2009-05-12	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
JP5180967B2 (ja) *	2006-11-03	2013-04-10	ブリストル−マイヤーズスクイブカンパニー	ピロロトリアジンキナーゼ阻害剤
US8268998B2 (en)	2006-11-03	2012-09-18	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
AR074830A1 (es)	2008-12-19	2011-02-16	Cephalon Inc	Pirrolotriazinas como inhibidores de alk y jak2
US8399451B2 (en) *	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
WO2011133734A1 (en)	2010-04-23	2011-10-27	Bristol-Myers Squibb Company	4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists
WO2012031057A1 (en)	2010-09-01	2012-03-08	Bristol-Myers Squibb Company	Bms- 582949 for the treatment of resistant rheumatic disease
US9187437B2 (en)	2010-09-24	2015-11-17	Bristol-Myers Squibb Company	Substituted oxadiazole compounds
CN103848833B (zh) *	2012-11-28	2016-08-31	上海希迈医药科技有限公司	吡咯并三嗪类衍生物、其制备方法及其在医药上的应用
WO2014082230A1 (zh) *	2012-11-28	2014-06-05	上海希迈医药科技有限公司	吡咯并三嗪类衍生物、其制备方法及其在医药上的应用
WO2014115171A1 (en)	2013-01-24	2014-07-31	Council Of Scientific & Industrial Research	Triazine compounds and a process for preparation thereof
CN103601722B (zh) *	2013-09-13	2016-03-02	南京华威医药科技开发有限公司	新型抗肿瘤化合物
JP6473146B2 (ja) *	2013-10-11	2019-02-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ピロロトリアジンキナーゼ阻害剤
JP6446040B2 (ja)	2013-10-17	2018-12-26	ブループリントメディシンズコーポレイション	Ｋｉｔに関連する疾患を治療するために有用な組成物
WO2015091156A1 (en)	2013-12-17	2015-06-25	Boehringer Ingelheim International Gmbh	Sulfoximine substituted pyrrolotriazines for pharmaceutical compositions
US11150238B2 (en) *	2017-01-05	2021-10-19	Biodesix, Inc.	Method for identification of cancer patients with durable benefit from immunotherapy in overall poor prognosis subgroups
US11040979B2 (en)	2017-03-31	2021-06-22	Blueprint Medicines Corporation	Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
MX2020003961A (es)	2017-10-05	2020-09-22	Fulcrum Therapeutics Inc	Uso de inhibidores de p38 para reducir la expresion de dux4.
WO2019168874A1 (en)	2018-02-27	2019-09-06	The Research Foundation For The State University Of New York	Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CA3093189A1 (en)	2018-03-07	2019-09-12	Bayer Aktiengesellschaft	Identification and use of erk5 inhibitors
EP3856341B1 (de)	2019-04-12	2023-09-06	Blueprint Medicines Corporation	Kristalline formen von s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amin und verfahren zur herstellung davon
PL3953357T3 (pl)	2019-04-12	2024-09-02	Blueprint Medicines Corporation	Pochodne pirolotriazyny do leczenia chorób mediowanych przez KIT i PDGFRA
TW202112368A (zh)	2019-06-13	2021-04-01	荷蘭商法西歐知識產權股份有限公司	用於治療有關dux4表現之疾病的抑制劑組合
CN110483497B (zh) *	2019-08-28	2022-12-30	郑州手性药物研究院有限公司	6-氨基甲基-1,1-二氧-1,2-苯并噻唑-3-酮中间体及其合成方法
CN110627706B (zh) *	2019-08-28	2023-02-10	郑州手性药物研究院有限公司	2-(4-甲基苄基)-1h-异吲哚-1,3-二酮衍生物及其合成方法
CN110483439B (zh) *	2019-08-28	2022-12-30	郑州手性药物研究院有限公司	6-氨基甲基-1,1-二氧-1,2-苯并噻唑-3-酮的合成方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3629301A (en)	1969-10-24	1971-12-21	Du Pont	3 3-difluoro-2-substituted steroids and their preparation
US4200750A (en)	1977-01-07	1980-04-29	Westwood Pharmaceuticals Inc.	4-Substituted imidazo [1,2-a]quinoxalines
RU2127274C1 (ru) *	1992-09-25	1999-03-10	Эли Лилли Энд Компани	СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
IL118544A (en)	1995-06-07	2001-08-08	Smithkline Beecham Corp	History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
JP2000503302A (ja)	1996-01-11	2000-03-21	スミスクライン・ビーチャム・コーポレイション	新規置換イミダゾール化合物
US6191131B1 (en) *	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6147080A (en)	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5945418A (en)	1996-12-18	1999-08-31	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5932576A (en)	1997-05-22	1999-08-03	G. D. Searle & Company	3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
US6087496A (en)	1998-05-22	2000-07-11	G. D. Searle & Co.	Substituted pyrazoles suitable as p38 kinase inhibitors
EP1019396A1 (de)	1997-07-02	2000-07-19	SmithKline Beecham Corporation	Cycloalkyl-substituierte imidazole
WO1999024033A1 (en) *	1997-11-12	1999-05-20	Shionogi & Co., Ltd.	Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
US6130235A (en)	1998-05-22	2000-10-10	Scios Inc.	Compounds and methods to treat cardiac failure and other disorders
US6184226B1 (en)	1998-08-28	2001-02-06	Scios Inc.	Quinazoline derivatives as inhibitors of P-38 α
KR20010082184A (ko)	1998-08-28	2001-08-29	추후제출	p38-α 키나제의 저해체
AU762245B2 (en) *	1998-09-18	2003-06-19	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
ES2191462T3 (es)	1998-10-01	2003-09-01	Astrazeneca Ab	Derivados de quinolina y quinazolina y su uso como inhibidores de enfermedades mediadas por citoquinas.
CA2346334A1 (en) *	1998-10-14	2000-04-20	Shionogi & Co., Ltd.	Composition for treating or preventing ischemia reperfusion injury
GB9906566D0 (en)	1999-03-23	1999-05-19	Zeneca Ltd	Chemical compounds
DE60042620D1 (de)	1999-05-21	2009-09-03	Bristol Myers Squibb Co	Pyrrolotriazine als Kinase Hemmer.
US6982265B1 (en)	1999-05-21	2006-01-03	Bristol Myers Squibb Company	Pyrrolotriazine inhibitors of kinases
JP4623483B2 (ja)	1999-08-23	2011-02-02	塩野義製薬株式会社	ｓＰＬＡ２阻害作用を有するピロロトリアジン誘導体
GB9924092D0 (en)	1999-10-13	1999-12-15	Zeneca Ltd	Pyrimidine derivatives
ES2237470T3 (es)	1999-11-10	2005-08-01	Ortho-Mcneil Pharmaceutical, Inc.	2-aril-3-(heteroaril)-imidazo(1,2-alfa)pirimidinas sustituidas; y composiciones farmaceuticas y procedimientos asociados.
US20020065270A1 (en) *	1999-12-28	2002-05-30	Moriarty Kevin Joseph	N-heterocyclic inhibitors of TNF-alpha expression
US6906067B2 (en) *	1999-12-28	2005-06-14	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of TNF-α expression
US6867300B2 (en) *	2000-11-17	2005-03-15	Bristol-Myers Squibb Company	Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
SK5402003A3 (en) *	2000-11-17	2004-06-08	Bristol Myers Squibb Co	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) *	2000-11-17	2003-12-30	Bristol-Myers Squibb Company	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
AU2002316421B2 (en) *	2001-06-26	2008-05-15	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of TNF-ALPHA expression
TW200300350A (en) *	2001-11-14	2003-06-01	Bristol Myers Squibb Co	C-5 modified indazolylpyrrolotriazines
UA78562C2 (en) *	2002-04-23	2007-04-10	Bristol Myers Squibb Co	Pyrrolo-triazine aniline compounds useful as kinase inhibitors
DE60325469D1 (de) *	2002-04-23	2009-02-05	Bristol Myers Squibb Co	Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen
TW200400034A (en) *	2002-05-20	2004-01-01	Bristol Myers Squibb Co	Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TWI272271B (en) *	2002-07-19	2007-02-01	Bristol Myers Squibb Co	Process for preparing certain pyrrolotriazine compounds
TWI329112B (en) *	2002-07-19	2010-08-21	Bristol Myers Squibb Co	Novel inhibitors of kinases
US6951859B2 (en) *	2002-08-02	2005-10-04	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
TW200420565A (en) *	2002-12-13	2004-10-16	Bristol Myers Squibb Co	C-6 modified indazolylpyrrolotriazines
MXPA05008183A (es) *	2003-02-05	2005-10-05	Bristol Myers Squibb Co	Proceso para preparar pirrolotriazina como inhibidores de cinasa.
MY145634A (en) *	2003-12-29	2012-03-15	Bristol Myers Squibb Co	Pyrrolotriazine compounds as kinase inhibitors
TW200600513A (en) *	2004-06-30	2006-01-01	Bristol Myers Squibb Co	A method for preparing pyrrolotriazine compounds
US7504521B2 (en) *	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
US7534882B2 (en) *	2005-04-06	2009-05-19	Bristol-Myers Squibb Company	Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
US20060235020A1 (en) *	2005-04-18	2006-10-19	Soojin Kim	Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
KR20080107408A (ko) *	2006-03-07	2008-12-10	브리스톨-마이어스 스큅 컴퍼니	키나제 억제제로서 유용한 피롤로트리아진 아닐린 전구약물화합물

2003
- 2003-04-15 UA UA20041109628A patent/UA78562C2/uk unknown
- 2003-04-15 EP EP20030724157 patent/EP1497019B1/de not_active Expired - Lifetime
- 2003-04-15 ES ES03724157.7T patent/ES2543711T3/es not_active Expired - Lifetime
- 2003-04-15 CA CA2483164A patent/CA2483164C/en not_active Expired - Fee Related
- 2003-04-15 PL PL373338A patent/PL219736B1/pl unknown
- 2003-04-15 CN CN201010616344.7A patent/CN102093363B/zh not_active Expired - Fee Related
- 2003-04-15 DK DK03724157.7T patent/DK1497019T3/en active
- 2003-04-15 MX MXPA04010379A patent/MXPA04010379A/es active IP Right Grant
- 2003-04-15 KR KR1020047017020A patent/KR101025675B1/ko not_active Expired - Fee Related
- 2003-04-15 JP JP2003587532A patent/JP4669225B2/ja not_active Expired - Fee Related
- 2003-04-15 RS YU92004A patent/RS92004A/sr unknown
- 2003-04-15 RU RU2004134337/04A patent/RU2375363C2/ru not_active IP Right Cessation
- 2003-04-15 EP EP10178247A patent/EP2289894A3/de not_active Withdrawn
- 2003-04-15 SI SI200332435T patent/SI1497019T1/sl unknown
- 2003-04-15 BR BR0309669-6A patent/BR0309669A/pt not_active Application Discontinuation
- 2003-04-15 CN CN038142937A patent/CN1662509A/zh active Pending
- 2003-04-15 NZ NZ536014A patent/NZ536014A/en not_active IP Right Cessation
- 2003-04-15 AU AU2003231034A patent/AU2003231034B2/en not_active Ceased
- 2003-04-15 PT PT37241577T patent/PT1497019E/pt unknown
- 2003-04-15 HU HUE03724157A patent/HUE025353T2/en unknown
- 2003-04-15 GE GEAP8506A patent/GEP20074148B/en unknown
- 2003-04-15 HR HR20040988A patent/HRP20040988A2/hr not_active Application Discontinuation
- 2003-04-15 WO PCT/US2003/012426 patent/WO2003090912A1/en active Application Filing
- 2003-04-18 TW TW092109121A patent/TWI312782B/zh not_active IP Right Cessation
- 2003-04-22 MY MYPI20031516A patent/MY132094A/en unknown
- 2003-04-22 US US10/420,399 patent/US7160883B2/en not_active Expired - Lifetime
- 2003-04-23 AR ARP030101401A patent/AR039649A1/es not_active Application Discontinuation
- 2003-04-23 PE PE2003000402A patent/PE20040590A1/es not_active Application Discontinuation
2004
- 2004-10-14 IS IS7505A patent/IS7505A/is unknown
- 2004-10-14 IL IL164573A patent/IL164573A/en not_active IP Right Cessation
- 2004-10-21 ZA ZA2004/08541A patent/ZA200408541B/en unknown
- 2004-10-22 NO NO20044560A patent/NO329503B1/no not_active IP Right Cessation
2006
- 2006-10-24 US US11/585,598 patent/US7462616B2/en not_active Expired - Lifetime
2007
- 2007-08-30 IL IL185604A patent/IL185604A0/en unknown
2008
- 2008-10-28 US US12/259,483 patent/US7759343B2/en not_active Expired - Lifetime
2010
- 2010-01-15 JP JP2010007097A patent/JP5226018B2/ja not_active Expired - Fee Related
- 2010-06-03 US US12/793,016 patent/US20100240646A1/en not_active Abandoned
- 2010-12-31 US US12/983,048 patent/US20110098467A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090105243A1 (en)	2009-04-23
PL373338A1 (en)	2005-08-22
ZA200408541B (en)	2006-01-25
CN102093363B (zh)	2016-12-07
RU2375363C2 (ru)	2009-12-10
JP2005523338A (ja)	2005-08-04
AU2003231034A1 (en)	2003-11-10
RU2004134337A (ru)	2005-06-27
RS92004A (en)	2006-12-15
MY132094A (en)	2007-09-28
IL164573A0 (en)	2005-12-18
JP2010132673A (ja)	2010-06-17
EP1497019A4 (de)	2006-06-14
NO20044560L (no)	2004-11-10
NZ536014A (en)	2006-12-22
BR0309669A (pt)	2005-03-01
IL185604A0 (en)	2008-01-06
WO2003090912A9 (en)	2004-01-08
WO2003090912A1 (en)	2003-11-06
MXPA04010379A (es)	2005-02-17
US7462616B2 (en)	2008-12-09
EP2289894A3 (de)	2011-07-20
CN1662509A (zh)	2005-08-31
ES2543711T3 (es)	2015-08-21
UA78562C2 (en)	2007-04-10
CN102093363A (zh)	2011-06-15
IS7505A (is)	2004-10-14
US20110098467A1 (en)	2011-04-28
JP5226018B2 (ja)	2013-07-03
US7160883B2 (en)	2007-01-09
US20070043053A1 (en)	2007-02-22
EP1497019A1 (de)	2005-01-19
PT1497019E (pt)	2015-09-10
IL164573A (en)	2010-12-30
CA2483164C (en)	2011-06-07
NO329503B1 (no)	2010-11-01
PL219736B1 (pl)	2015-07-31
AU2003231034B2 (en)	2009-03-05
TWI312782B (en)	2009-08-01
SI1497019T1 (sl)	2015-08-31
US20040082582A1 (en)	2004-04-29
HUE025353T2 (en)	2016-02-29
TW200402422A (en)	2004-02-16
KR20040102157A (ko)	2004-12-03
KR101025675B1 (ko)	2011-03-30
US20100240646A1 (en)	2010-09-23
CA2483164A1 (en)	2003-11-06
AR039649A1 (es)	2005-03-02
EP1497019B1 (de)	2015-05-20
PE20040590A1 (es)	2004-08-28
US7759343B2 (en)	2010-07-20
GEP20074148B (en)	2007-07-10
DK1497019T3 (en)	2015-08-03
JP4669225B2 (ja)	2011-04-13
EP2289894A2 (de)	2011-03-02

Publication	Publication Date	Title
HRP20040988A2 (en)	2005-06-30	Pyrrolo-triazine aniline compounds useful as kinas
US6670357B2 (en)	2003-12-30	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US7314876B2 (en)	2008-01-01	Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
EP1363910B1 (de)	2006-03-01	Verfahren zur Behandlung von mit p38-Kinase assoziierten Leiden und Pyrrolotriazin-Verbindungen als Kinaseinhibitoren.
JP2009535295A (ja)	2009-10-01	キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物
US7388009B2 (en)	2008-06-17	Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
HK1057555B (en)	2006-09-15	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors

Legal Events

Date	Code	Title	Description
2005-06-30	A1OB	Publication of a patent application
2005-12-02	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2015-03-06	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20150306 Year of fee payment: 13
2015-11-13	ODBI	Application refused