HRP20020264B1 - 2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže - Google Patents

2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže

Info

Publication number: HRP20020264B1
Authority: HR; Croatia
Prior art keywords: carbon atoms; alkyl; phenyl; substituted; conh2
Prior art date: 1999-10-02

Application number

HR20020264A

Other languages

English (en)

Croatian (hr)

Inventor

Brendel Joachim

Schmidt Wolfgang

Below Peter

Original Assignee

Sanofi-Aventis Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-02

Filing date

2000-09-19

Publication date

2010-08-31

2000-09-19 Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh

2004-02-29 Publication of HRP20020264A2 publication Critical patent/HRP20020264A2/hr

2010-08-31 Publication of HRP20020264B1 publication Critical patent/HRP20020264B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

HR20020264A 1999-10-02 2000-09-19 2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže HRP20020264B1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19947457A DE19947457A1 (de)	1999-10-02	1999-10-02	2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
PCT/EP2000/009151 WO2001025189A1 (de)	1999-10-02	2000-09-19	2'-substituierte 1,1'-biphenyl-2-carbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number	Publication Date
HRP20020264A2 HRP20020264A2 (en)	2004-02-29
HRP20020264B1 true HRP20020264B1 (hr)	2010-08-31

Family

ID=7924254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020264A HRP20020264B1 (hr)	1999-10-02	2000-09-19	2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže

Country Status (32)

Country	Link
EP (1)	EP1222163B1 (xx)
JP (1)	JP4713800B2 (xx)
KR (1)	KR100722178B1 (xx)
CN (1)	CN1195738C (xx)
AR (1)	AR031226A1 (xx)
AT (1)	ATE332890T1 (xx)
AU (1)	AU766365B2 (xx)
BR (1)	BR0014465B1 (xx)
CA (1)	CA2385859C (xx)
CY (1)	CY1106178T1 (xx)
CZ (1)	CZ302591B6 (xx)
DE (2)	DE19947457A1 (xx)
DK (1)	DK1222163T3 (xx)
EE (1)	EE05000B1 (xx)
ES (1)	ES2265985T3 (xx)
HK (1)	HK1048986B (xx)
HR (1)	HRP20020264B1 (xx)
HU (1)	HU229046B1 (xx)
IL (2)	IL148870A0 (xx)
ME (1)	MEP60908A (xx)
MX (1)	MXPA02002691A (xx)
NO (1)	NO327709B1 (xx)
NZ (1)	NZ518065A (xx)
PL (1)	PL204034B1 (xx)
PT (1)	PT1222163E (xx)
RS (1)	RS50387B (xx)
RU (1)	RU2252214C2 (xx)
SK (1)	SK286756B6 (xx)
TR (1)	TR200200883T2 (xx)
TW (1)	TWI270541B (xx)
WO (1)	WO2001025189A1 (xx)
ZA (1)	ZA200202521B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002000606A1 (fr)	2000-06-28	2002-01-03	Takeda Chemical Industries, Ltd.	Compose biphenyle
DE10059418A1 (de) *	2000-11-30	2002-06-20	Aventis Pharma Gmbh	Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10060807A1 (de)	2000-12-07	2002-06-20	Aventis Pharma Gmbh	Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
TWI311133B (en)	2001-04-20	2009-06-21	Eisai R&D Man Co Ltd	Carboxylic acid derivativeand the salt thereof
DE10121003A1 (de)	2001-04-28	2002-12-19	Aventis Pharma Gmbh	Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
EP1394147A4 (en) *	2001-06-04	2007-10-24	Eisai R&D Man Co Ltd	CARBOXYLENE DERIVATIVE AND A SALT OR AN ESTER CONTAINING MEDICINE
DE10128331A1 (de)	2001-06-12	2002-12-19	Aventis Pharma Gmbh	Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
EP1466904A4 (en) *	2001-12-28	2005-12-14	Takeda Pharmaceutical	BIARYL CONNECTION AND ITS USE
KR20050071598A (ko) *	2002-10-24	2005-07-07	메르크 파텐트 게엠베하	라프-키나아제 억제제로서의 메틸렌 우레아 유도체
DE10312061A1 (de) *	2003-03-18	2004-09-30	Aventis Pharma Deutschland Gmbh	Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
EP1663204B1 (en) *	2003-08-29	2014-05-07	Exelixis, Inc.	C-kit modulators and methods of use
DE10341233A1 (de) *	2003-09-08	2005-03-24	Aventis Pharma Deutschland Gmbh	Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
DE102004009931A1 (de) *	2004-02-26	2005-09-15	Aventis Pharma Deutschland Gmbh	Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz
WO2005087236A1 (en) *	2004-03-11	2005-09-22	Glaxo Group Limited	Novel m3 muscarinic acetylcholine receptor antagonists
GB0412986D0 (en)	2004-06-10	2004-07-14	Xention Discovery Ltd	Compounds
US7569589B2 (en)	2004-07-29	2009-08-04	Merck & Co., Inc.	Potassium channel inhibitors
US7576212B2 (en)	2004-12-09	2009-08-18	Xention Limited	Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0525164D0 (en)	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
MX2008012920A (es) *	2006-04-27	2008-10-15	Sanofi Aventis Deutschland	Inhibidores de los canales de iones task-1 y task-3.
GB0815782D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815784D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815781D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
BRPI1011098A2 (pt)	2009-06-03	2016-04-12	Sanofi Aventis Deutschland	fases cristalinas de (2-piridin-3-il-etil)-amida de ácido 2'-{[2-(4-metóxi-fenil)-acetilamino]metil}-bifenil-2-carboxílico.
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
NO3175985T3 (xx)	2011-07-01	2018-04-28
NZ627942A (en)	2012-01-27	2016-03-31	Gilead Sciences Inc	Combination therapies using late sodium ion channel blockers and potassium ion channel blockers

Citations (1)

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EP0620216A1 (en) *	1993-04-13	1994-10-19	Fujisawa Pharmaceutical Co., Ltd.	Benzamide derivatives and their use as vasopressin antagonists

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SE8705150D0 (sv) *	1987-12-23	1987-12-23	Haessle Ab	Novel antiarrhythmic agents
DE4102024A1 (de) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

1999
- 1999-10-02 DE DE19947457A patent/DE19947457A1/de not_active Withdrawn
2000
- 2000-01-11 TW TW2'-SUBSTIA patent/TWI270541B/zh not_active IP Right Cessation
- 2000-09-19 AU AU77778/00A patent/AU766365B2/en not_active Ceased
- 2000-09-19 NZ NZ518065A patent/NZ518065A/en not_active IP Right Cessation
- 2000-09-19 ES ES00967703T patent/ES2265985T3/es not_active Expired - Lifetime
- 2000-09-19 HU HU0203505A patent/HU229046B1/hu not_active IP Right Cessation
- 2000-09-19 PT PT00967703T patent/PT1222163E/pt unknown
- 2000-09-19 WO PCT/EP2000/009151 patent/WO2001025189A1/de active IP Right Grant
- 2000-09-19 RU RU2002111561/04A patent/RU2252214C2/ru not_active IP Right Cessation
- 2000-09-19 PL PL354322A patent/PL204034B1/pl unknown
- 2000-09-19 BR BRPI0014465-7A patent/BR0014465B1/pt not_active IP Right Cessation
- 2000-09-19 HK HK03101193.0A patent/HK1048986B/zh not_active IP Right Cessation
- 2000-09-19 JP JP2001528137A patent/JP4713800B2/ja not_active Expired - Fee Related
- 2000-09-19 SK SK438-2002A patent/SK286756B6/sk not_active IP Right Cessation
- 2000-09-19 EP EP00967703A patent/EP1222163B1/de not_active Expired - Lifetime
- 2000-09-19 TR TR2002/00883T patent/TR200200883T2/xx unknown
- 2000-09-19 DE DE50013167T patent/DE50013167D1/de not_active Expired - Lifetime
- 2000-09-19 CZ CZ20021144A patent/CZ302591B6/cs not_active IP Right Cessation
- 2000-09-19 CN CNB008127344A patent/CN1195738C/zh not_active Expired - Fee Related
- 2000-09-19 IL IL14887000A patent/IL148870A0/xx active IP Right Grant
- 2000-09-19 EE EEP200200160A patent/EE05000B1/xx not_active IP Right Cessation
- 2000-09-19 DK DK00967703T patent/DK1222163T3/da active
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2002
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2006
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Publication number	Publication date
HRP20020264A2 (en)	2004-02-29
RS50387B (sr)	2009-12-31
NO20021398D0 (no)	2002-03-20
HK1048986B (zh)	2005-07-29
NO327709B1 (no)	2009-09-14
AU766365B2 (en)	2003-10-16
CZ302591B6 (cs)	2011-07-27
CA2385859A1 (en)	2001-04-12
WO2001025189A1 (de)	2001-04-12
JP2003511363A (ja)	2003-03-25
DE50013167D1 (de)	2006-08-24
HK1048986A1 (en)	2003-04-25
EE200200160A (et)	2003-04-15
CN1195738C (zh)	2005-04-06
AU7777800A (en)	2001-05-10
ES2265985T3 (es)	2007-03-01
KR20020038791A (ko)	2002-05-23
AR031226A1 (es)	2003-09-17
ZA200202521B (en)	2002-12-24
CY1106178T1 (el)	2011-06-08
CN1373750A (zh)	2002-10-09
IL148870A (en)	2007-05-15
BR0014465B1 (pt)	2011-12-27
DE19947457A1 (de)	2001-04-05
SK4382002A3 (en)	2002-08-06
NZ518065A (en)	2004-08-27
HUP0203505A2 (hu)	2003-03-28
PL354322A1 (en)	2004-01-12
MXPA02002691A (es)	2002-07-30
RU2002111561A (ru)	2004-01-20
TWI270541B (xx)	2007-01-11
RU2252214C2 (ru)	2005-05-20
PL204034B1 (pl)	2009-12-31
BR0014465A (pt)	2002-06-11
CZ20021144A3 (cs)	2002-06-12
PT1222163E (pt)	2006-10-31
TR200200883T2 (tr)	2002-09-23
KR100722178B1 (ko)	2007-05-29
EP1222163B1 (de)	2006-07-12
IL148870A0 (en)	2002-09-12
JP4713800B2 (ja)	2011-06-29
DK1222163T3 (da)	2006-11-13
EP1222163A1 (de)	2002-07-17
YU24402A (sh)	2005-06-10
NO20021398L (no)	2002-05-31
CA2385859C (en)	2009-11-24
EE05000B1 (et)	2008-04-15
ATE332890T1 (de)	2006-08-15
SK286756B6 (sk)	2009-05-07
HUP0203505A3 (en)	2004-01-28
MEP60908A (en)	2011-05-10
HU229046B1 (hu)	2013-07-29

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HRP20020264B1 (hr)	2010-08-31	2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže
RS50403B (sr)	2009-12-31	Orto, meta-supstituisana bis-aril jedinjenja, postupak za njihovu proizvodnju,njihova primena u svojstvu leka i farmaceutski preparati koji sadrže ta jedinjenja
HRP20030448B1 (en)	2006-06-30	Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors
HUP0200207A2 (hu)	2002-05-29	Helyettesített 2-aril-(heteroaril)-imidazo [1,2-a]pirimidin-származékok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0402026A2 (hu)	2005-02-28	5,6-Diaril-pirazin-2-amid-származékok mint CB1 antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
ES8101586A1 (es)	1980-12-16	Un procedimiento para la preparacion de nuevos derivados de quinazolina.
RU2003120080A (ru)	2004-12-27	Орто-замещенные азотсодержащие бисарильные соединения для применения в качестве ингибиторов калиевого канала, а также содержащие их фармацевтические композиции
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EA200000731A1 (ru)	2001-02-26	Альфа-аминоамидные производные, полезные в качестве анальгетических агентов
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DE60317889D1 (de)	2008-01-17	Antivirale bicyclo-4.4.0-derivate
AU2736088A (en)	1989-06-29	Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
AP1564A (en)	2006-02-02	Piperazinyl sulfonic acid derivatives, their pharmaceutical compositions and methods of use.
ES457745A1 (es)	1978-07-16	Procedimiento para la preparacion de nuevas fluoracil-resor-cinas sustituidas.
KR920006322A (ko)	1992-04-27	벤젠, 피리딘 및 피리미딘 유도체
EP0765865A4 (en)	1997-08-13	2-ACYLAMINOPROPANOL COMPOUND AND MEDICINAL COMPOSITION
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SE9904177D0 (sv)	1999-11-18	Novel compounds
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