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HRP20010935A2 - Respiratory syncytial virus replication inhibitors - Google Patents

Respiratory syncytial virus replication inhibitors Download PDF

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Publication number
HRP20010935A2
HRP20010935A2 HR20010935A HRP20010935A HRP20010935A2 HR P20010935 A2 HRP20010935 A2 HR P20010935A2 HR 20010935 A HR20010935 A HR 20010935A HR P20010935 A HRP20010935 A HR P20010935A HR P20010935 A2 HRP20010935 A2 HR P20010935A2
Authority
HR
Croatia
Prior art keywords
formula
alkyl
methyl
image
hydrogen
Prior art date
Application number
HR20010935A
Other languages
English (en)
Croatian (hr)
Inventor
Frans Eduard Janssens
Kathleen
Francois Maria Sommen
Koenraad
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20010935A2 publication Critical patent/HRP20010935A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20010935A 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors HRP20010935A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (1)

Publication Number Publication Date
HRP20010935A2 true HRP20010935A2 (en) 2003-06-30

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010935A HRP20010935A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Country Status (33)

Country Link
US (3) US6747028B1 (bg)
EP (1) EP1196409B1 (bg)
JP (1) JP2003503402A (bg)
KR (1) KR100731271B1 (bg)
CN (1) CN1210275C (bg)
AR (1) AR035991A1 (bg)
AT (1) ATE258928T1 (bg)
AU (1) AU778218B2 (bg)
BG (1) BG65328B1 (bg)
BR (1) BR0012047A (bg)
CA (1) CA2376676C (bg)
DE (1) DE60008112T2 (bg)
DK (1) DK1196409T3 (bg)
EA (1) EA005027B1 (bg)
EE (1) EE04591B1 (bg)
ES (1) ES2215683T3 (bg)
HK (1) HK1045997A1 (bg)
HR (1) HRP20010935A2 (bg)
HU (1) HUP0201869A3 (bg)
IL (2) IL147327A0 (bg)
MX (1) MXPA02000120A (bg)
MY (1) MY127687A (bg)
NO (1) NO322458B1 (bg)
NZ (1) NZ515664A (bg)
PL (1) PL200674B1 (bg)
PT (1) PT1196409E (bg)
SI (1) SI1196409T1 (bg)
SK (1) SK19122001A3 (bg)
TR (1) TR200103806T2 (bg)
TW (1) TWI278454B (bg)
UA (1) UA74787C2 (bg)
WO (1) WO2001000612A2 (bg)
ZA (1) ZA200110479B (bg)

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EP1418175A1 (en) * 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
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US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
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US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
CA2495266A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1539691A2 (en) 2002-08-09 2005-06-15 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
AU2003301436A1 (en) * 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
WO2005042530A1 (en) 2003-10-30 2005-05-12 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
AR046771A1 (es) * 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio
WO2005058869A1 (en) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
ES2326813T3 (es) 2003-12-18 2009-10-20 Tibotec Pharmaceuticals Ltd. Derivados de amino-bencimidazoles como inhibidores de la replicacion del virus respiratorio sincitial.
CN1894236B (zh) * 2003-12-18 2011-08-17 泰博特克药品有限公司 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物
MY142783A (en) * 2003-12-18 2010-12-31 Tibotec Pharm Ltd 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
DE102004010207A1 (de) * 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
US7956196B2 (en) 2005-03-17 2011-06-07 Tibotec Pharmaceuticals Ltd. 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
US8034835B2 (en) 2005-06-20 2011-10-11 Tibotec Pharmaceuticals Ltd. 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs
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TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
HUE035069T2 (en) 2011-12-28 2018-05-02 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
AR091455A1 (es) 2012-06-15 2015-02-04 Janssen R & D Ireland Derivados 1,3-dihidro-2h-benzimidazol-2-ona sustituidos con heterociclos como agentes antivirales para el virus sincicial respiratorio
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
AP2015008721A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
ES2993155T3 (en) 2013-03-15 2024-12-23 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
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Also Published As

Publication number Publication date
US7179811B2 (en) 2007-02-20
TR200103806T2 (tr) 2002-06-21
US20070015747A1 (en) 2007-01-18
PL352378A1 (en) 2003-08-25
AR035991A1 (es) 2004-08-04
EP1196409B1 (en) 2004-02-04
MY127687A (en) 2006-12-29
HUP0201869A2 (hu) 2002-11-28
SI1196409T1 (en) 2004-06-30
US6747028B1 (en) 2004-06-08
PL200674B1 (pl) 2009-01-30
WO2001000612A3 (en) 2001-03-29
NO20016369L (no) 2002-02-20
US20070135404A1 (en) 2007-06-14
NO20016369D0 (no) 2001-12-27
SK19122001A3 (sk) 2003-01-09
KR20020003884A (ko) 2002-01-15
MXPA02000120A (es) 2002-07-02
KR100731271B1 (ko) 2007-06-21
DE60008112D1 (en) 2004-03-11
HUP0201869A3 (en) 2003-12-29
WO2001000612A2 (en) 2001-01-04
AU5816600A (en) 2001-01-31
EA005027B1 (ru) 2004-10-28
BG65328B1 (bg) 2008-02-29
TWI278454B (en) 2007-04-11
US7528149B2 (en) 2009-05-05
DE60008112T2 (de) 2004-09-16
CA2376676C (en) 2009-01-20
ATE258928T1 (de) 2004-02-15
BR0012047A (pt) 2002-03-12
UA74787C2 (en) 2006-02-15
CA2376676A1 (en) 2001-01-04
ES2215683T3 (es) 2004-10-16
NO322458B1 (no) 2006-10-09
JP2003503402A (ja) 2003-01-28
IL147327A (en) 2007-06-03
AU778218B2 (en) 2004-11-25
EE200100688A (et) 2003-04-15
ZA200110479B (en) 2003-03-20
DK1196409T3 (da) 2004-06-07
EE04591B1 (et) 2006-02-15
CN1210275C (zh) 2005-07-13
CN1358181A (zh) 2002-07-10
IL147327A0 (en) 2002-08-14
EA200200088A1 (ru) 2002-06-27
PT1196409E (pt) 2004-06-30
NZ515664A (en) 2004-01-30
BG106286A (bg) 2002-10-31
HK1045997A1 (zh) 2002-12-20
EP1196409A2 (en) 2002-04-17

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