[go: up one dir, main page]

HK1258304A1 - 優化抗cd3雙特異性抗體和其用途 - Google Patents

優化抗cd3雙特異性抗體和其用途

Info

Publication number
HK1258304A1
HK1258304A1 HK19100669.9A HK19100669A HK1258304A1 HK 1258304 A1 HK1258304 A1 HK 1258304A1 HK 19100669 A HK19100669 A HK 19100669A HK 1258304 A1 HK1258304 A1 HK 1258304A1
Authority
HK
Hong Kong
Prior art keywords
bispecific antibodies
optimized anti
optimized
bispecific
antibodies
Prior art date
Application number
HK19100669.9A
Other languages
English (en)
Inventor
Eric Smith
Lauric Haber
Robert Babb
Gang Chen
Douglas Macdonald
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1258304A1 publication Critical patent/HK1258304A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK19100669.9A 2015-09-23 2019-01-15 優化抗cd3雙特異性抗體和其用途 HK1258304A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222605P 2015-09-23 2015-09-23
PCT/US2016/053525 WO2017053856A1 (en) 2015-09-23 2016-09-23 Optimized anti-cd3 bispecific antibodies and uses thereof

Publications (1)

Publication Number Publication Date
HK1258304A1 true HK1258304A1 (zh) 2019-11-08

Family

ID=57130447

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19100669.9A HK1258304A1 (zh) 2015-09-23 2019-01-15 優化抗cd3雙特異性抗體和其用途

Country Status (29)

Country Link
US (2) US20180355038A1 (zh)
EP (1) EP3353212B1 (zh)
JP (3) JP7023231B2 (zh)
KR (1) KR102777500B1 (zh)
CN (1) CN108290951B (zh)
AU (1) AU2016325630B2 (zh)
BR (1) BR112018005445A2 (zh)
CA (1) CA2999385A1 (zh)
CY (1) CY1124944T1 (zh)
DK (1) DK3353212T3 (zh)
EA (1) EA201890785A1 (zh)
ES (1) ES2901133T3 (zh)
HK (1) HK1258304A1 (zh)
HR (1) HRP20220133T8 (zh)
HU (1) HUE057683T2 (zh)
IL (1) IL258036B (zh)
LT (1) LT3353212T (zh)
MA (1) MA42935B1 (zh)
MD (1) MD3353212T2 (zh)
MX (1) MX2018003403A (zh)
MY (1) MY195059A (zh)
PL (1) PL3353212T3 (zh)
PT (1) PT3353212T (zh)
RS (1) RS62859B1 (zh)
SI (1) SI3353212T1 (zh)
SM (1) SMT202200050T1 (zh)
TW (2) TWI783914B (zh)
WO (1) WO2017053856A1 (zh)
ZA (1) ZA201801673B (zh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP6681396B2 (ja) 2014-11-17 2020-04-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｃｄ３ｘｃｄ２０二特異性抗体を用いて腫瘍を治療する方法
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
EP3303400B1 (en) 2015-05-28 2020-09-09 Genentech, Inc. Cell-based assay for detecting anti-cd3 homodimers
TW202440904A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（二）
EA201892010A1 (ru) 2016-04-20 2019-03-29 Регенерон Фармасьютикалз, Инк. Композиции и способы получения антител, основанные на применении локусов, обеспечивающих повышенную экспрессию
SG11201807881VA (en) 2016-04-20 2018-10-30 Regeneron Pharma Compositions and methods for making antibodies based on use of an expression-enhancing locus
ES2952735T3 (es) 2016-09-23 2023-11-03 Regeneron Pharma Anticuerpos anti-MUC16-CD3 biespecíficos y conjugados anti-MUC16-fármaco
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
CA3068056A1 (en) * 2017-06-22 2018-12-27 Development Center For Biotechnology Asymmetric heterodimeric fc-scfv fusion anti-globo h and anti-cd3 bispecifc antibody and uses thereof in cancer therapy
BR112020002695A2 (pt) * 2017-08-09 2020-08-25 Merus N.V. anticorpos que se ligam à egfr e cmet
EA039842B1 (ru) * 2017-09-14 2022-03-18 Ридженерон Фармасьютикалз, Инк. Биспецифичные анти-muc16-cd3 антитела и конъюгаты анти-muc16-лекарственное средство
WO2019067682A1 (en) * 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. BISPECIFIC ANTIGEN-BINDING MOLECULES BINDING TO TARGET STAPHYLOCOCCUS ANTIGEN AND COMPONENT COMPONENT, AND USES THEREOF
KR20200104364A (ko) * 2017-12-27 2020-09-03 테네오바이오, 인코포레이티드 Cd3-델타/엡실론 이형이량체 특이적 항체
TW202005985A (zh) 2018-06-21 2020-02-01 美商再生元醫藥公司 用雙特異性抗ＣＤ３ｘＭＵＣ１６抗體及抗ＰＤ－１抗體治療癌症的方法
MX2020013804A (es) 2018-06-21 2021-03-31 Regeneron Pharma Anticuerpos anti-psma x anti-cd28 biespecíficos y usos de estos.
CR20210047A (es) 2018-07-02 2021-05-21 Amgen Inc Proteína de unión al antígeno anti-steap1
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
FI3823665T3 (fi) 2018-07-19 2024-03-01 Regeneron Pharma BCMA-spesifisiä kimeerisiä antigeenireseptoreita ja niiden käyttöjä
AU2019325565A1 (en) 2018-08-23 2021-03-11 Regeneron Pharmaceuticals, Inc. Anti-Fc epsilon-R1 alpha (FceR1a) antibodies, bispecific antigen-binding molecules that bind FceR1a and CD3, and uses thereof
MA53495A (fr) 2018-08-31 2021-12-08 Regeneron Pharma Stratégie de dosage permettant d'atténuer le syndrome de libération de cytokines pour des anticorps bispécifiques cd3/c20
EP3863721A1 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. 5t4 single domain antibodies and therapeutic compositions thereof
EP3864049A1 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
CN113166261A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 B7h3单域抗体及其治疗性组合物
WO2020076977A2 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
WO2020052692A2 (en) 2018-12-04 2020-03-19 Novartis Ag Binding molecules against cd3 and uses thereof
KR20210100654A (ko) * 2018-12-07 2021-08-17 지앙수 헨그루이 메디슨 컴퍼니 리미티드 Cd3 항체 및 그의 약제학적 용도
KR20210104758A (ko) 2018-12-19 2021-08-25 리제너론 파아마슈티컬스, 인크. 이중특이적 항-muc16 x 항-cd28 항체 및 이의 용도
EP3897715A1 (en) 2018-12-19 2021-10-27 Regeneron Pharmaceuticals, Inc. Bispecific anti-cd28 x anti-cd22 antibodies and uses thereof
JP2022526764A (ja) 2019-03-22 2022-05-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ＥＧＦＲｘＣＤ２８多特異性抗体
WO2020236792A1 (en) 2019-05-21 2020-11-26 Novartis Ag Cd19 binding molecules and uses thereof
JP2022537019A (ja) * 2019-06-21 2022-08-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｐｓｍａおよびｃｄ３に結合する二重特異性抗原結合分子の４－１ｂｂ共刺激と組み合わせての使用
BR112021026089A2 (pt) * 2019-06-26 2022-03-22 Amunix Pharmaceuticals Inc Fragmentos de ligação ao antígeno de cd3 e composições compreendendo os mesmos
WO2021006199A1 (ja) 2019-07-05 2021-01-14 小野薬品工業株式会社 Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療
AU2020330063A1 (en) 2019-08-15 2022-03-24 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules for cell targeting and uses thereof
CN110551222B (zh) * 2019-08-27 2023-06-06 重庆市畜牧科学院 一种新型双功能抗体及其用途
WO2021113701A1 (en) 2019-12-06 2021-06-10 Regeneron Pharmaceuticals, Inc. Methods of treating multiple myeloma with bispecific anti-bcma x anti-cd3 antibodies
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
AU2021345124A1 (en) 2020-09-16 2023-03-30 Amgen Inc. Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer
US20220233690A1 (en) 2021-01-28 2022-07-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cytokine release syndrome
WO2022192895A1 (en) * 2021-03-10 2022-09-15 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods to reduce therapeutic t cell toxicity
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
WO2023097219A2 (en) * 2021-11-24 2023-06-01 Adimab, Llc Anti-idiotype antibodies
AU2023245607A1 (en) 2022-03-29 2024-10-31 Ngm Biopharmaceuticals, Inc. Ilt3 and cd3 binding agents and methods of use thereof
US20230357446A1 (en) 2022-04-11 2023-11-09 Regeneron Pharmaceuticals, Inc. Compositions and methods for universal tumor cell killing
CN114685675B (zh) * 2022-04-27 2023-02-03 深圳市汉科生物工程有限公司 双特异性抗体及其在治疗癌症中的用途
WO2024012513A1 (en) * 2022-07-13 2024-01-18 Hansoh Bio Llc Antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
WO2024077044A1 (en) 2022-10-05 2024-04-11 Amgen Inc. Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof
WO2024081180A1 (en) 2022-10-10 2024-04-18 Regeneron Pharmaceuticals, Inc. Methods for reducing alloantibody levels in subjects in need of solid organ transplantation
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer
US20240277844A1 (en) 2023-02-17 2024-08-22 Regeneron Pharmaceuticals, Inc. Induced nk cells responsive to cd3/taa bispecific antibodies
WO2024191983A1 (en) 2023-03-13 2024-09-19 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with bispecific anti-cd22 x anti-cd28 molecules
US20250043017A1 (en) 2023-07-10 2025-02-06 Regeneron Pharmaceuticals, Inc. BISPECIFIC PD-L1x4-1BB ANTIBODIES AND METHODS OF USE THEREOF
WO2025014913A1 (en) 2023-07-10 2025-01-16 Regeneron Pharmaceuticals, Inc. Bispecific pd-l1xcd28 antibodies and methods of use thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
WO2003026490A2 (en) * 2001-09-28 2003-04-03 Elusys Therapeutics, Inc. Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules
US7820166B2 (en) 2002-10-11 2010-10-26 Micromet Ag Potent T cell modulating molecules
ATE455127T1 (de) 2003-05-31 2010-01-15 Micromet Ag Humane anti-humane cd3-bindungsmoleküle
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
CN102875681A (zh) * 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
US20110313134A1 (en) * 2008-11-06 2011-12-22 Alexion Pharmaceuticals, Inc. Engineered antibodies with reduced immunogenicity and methods of making
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
CA2780221A1 (en) 2009-11-04 2011-05-12 Fabrus Llc Methods for affinity maturation-based antibody optimization
LT3095871T (lt) 2010-02-08 2019-05-27 Regeneron Pharmaceuticals, Inc. Bendros lengvosios grandinės pelė
PL3042917T3 (pl) * 2010-08-12 2018-07-31 Eli Lilly And Company Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
JP6159724B2 (ja) * 2011-08-23 2017-07-05 ロシュ グリクアート アーゲー Ｔ細胞活性化抗原に対して特異的な二重特異性抗体及び腫瘍抗原および使用方法
WO2013157105A1 (ja) * 2012-04-18 2013-10-24 公立大学法人大阪市立大学 ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用
JP2015525071A (ja) * 2012-06-05 2015-09-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法
DE102012214441B4 (de) * 2012-08-14 2020-08-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messverfahren
JOP20200236A1 (ar) * 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
EP2900694B1 (en) * 2012-09-27 2018-09-12 Merus N.V. Bispecific igg antibodies as t cell engagers
EP2904016B1 (en) * 2012-10-08 2018-11-14 Roche Glycart AG Fc-free antibodies comprising two fab-fragments and methods of use
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
CA2925677A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Bispecific her2 antibodies and methods of use
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JOP20160154B1 (ar) * 2015-07-31 2021-08-17 Regeneron Pharma أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
BR112019005641A2 (pt) * 2016-09-23 2019-07-30 Regeneron Pharma Anticorpos antisteap2, conjugados anticorpo-fármaco e moléculas de ligaçãoa antígeno biespecíficas que ligam steap2 e cd3, e usos dos mesmos
ES2952735T3 (es) * 2016-09-23 2023-11-03 Regeneron Pharma Anticuerpos anti-MUC16-CD3 biespecíficos y conjugados anti-MUC16-fármaco
AU2020330063A1 (en) * 2019-08-15 2022-03-24 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules for cell targeting and uses thereof

Also Published As

Publication number Publication date
MA42935B1 (fr) 2022-02-28
HRP20220133T8 (hr) 2022-05-13
JP7023231B2 (ja) 2022-02-21
JP2023154021A (ja) 2023-10-18
CY1124944T1 (el) 2023-01-05
KR20180050412A (ko) 2018-05-14
CN108290951B (zh) 2022-04-01
DK3353212T3 (da) 2021-12-20
CN108290951A (zh) 2018-07-17
JP2018537516A (ja) 2018-12-20
ZA201801673B (en) 2022-12-21
TW201726713A (zh) 2017-08-01
CA2999385A1 (en) 2017-03-30
MD3353212T2 (ro) 2022-03-31
IL258036B (en) 2022-09-01
TWI784917B (zh) 2022-11-21
TWI783914B (zh) 2022-11-21
IL258036A (en) 2018-05-31
SMT202200050T1 (it) 2022-03-21
EA201890785A1 (ru) 2018-10-31
MY195059A (en) 2023-01-05
PL3353212T3 (pl) 2022-03-28
KR102777500B1 (ko) 2025-03-11
ES2901133T3 (es) 2022-03-21
HRP20220133T1 (hr) 2022-04-15
US20180355038A1 (en) 2018-12-13
TW202241514A (zh) 2022-11-01
JP2022064886A (ja) 2022-04-26
MX2018003403A (es) 2018-05-28
MA42935A (fr) 2018-08-01
BR112018005445A2 (pt) 2018-10-09
HUE057683T2 (hu) 2022-05-28
AU2016325630B2 (en) 2022-11-17
EP3353212B1 (en) 2021-11-03
LT3353212T (lt) 2021-12-27
PT3353212T (pt) 2022-01-05
SI3353212T1 (sl) 2022-01-31
EP3353212A1 (en) 2018-08-01
AU2016325630A1 (en) 2018-04-26
RS62859B1 (sr) 2022-02-28
US20210253701A1 (en) 2021-08-19
WO2017053856A1 (en) 2017-03-30

Similar Documents

Publication Publication Date Title
HK1258304A1 (zh) 優化抗cd3雙特異性抗體和其用途
IL289946A (en) Bispecific antibodies against cd3 and cd20
HK1256365A1 (zh) 對pd1和tim3特異性的雙特異性抗體
ZA201902265B (en) Anti-pd-1 antibodies and their uses
HK1254880A1 (zh) 抗pd-1抗體及其應用
HK1252857A1 (zh) 抗cd3抗體及其使用方法
HK1246312A1 (zh) 抗ceacam6抗體及其用途
IL267070A (en) Antibodies against ox40 and their uses
PL3519437T3 (pl) Przeciwciała dwuswoiste przeciwko p95HER2
HK1218299A1 (zh) Ε和 的雙特異性抗體
SG11201704577TA (en) Bispecific antibodies against cd3epsilon and bcma
GB201710838D0 (en) Bispecific antibodies
IL271128A (en) New anti-3cd antibodies
IL258924A (en) Humanized anti-Dicoff-related protein 2 antibody and uses thereof
IL269577B (en) Bispecific antibodies anti–pd–l1–anti–tim–3