HK1257363A1 - 用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物 - Google Patents

用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物

Info

Publication number: HK1257363A1
Authority: HK; Hong Kong
Prior art keywords: polymerase; inhibition; pyrrolopyrimidine derivatives; pyrrolopyrimidine; derivatives
Prior art date: 2010-10-15

Application number

HK18116571.3A

Other languages

English (en)

Inventor

Shanta Bantia

Pravin L Kotian

Yarlagadda S Babu

Original Assignee

Biocryst Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-10-15

Filing date

2018-12-25

Publication date

2019-10-18

2018-12-25 Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc

2019-10-18 Publication of HK1257363A1 publication Critical patent/HK1257363A1/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HK18116571.3A 2010-10-15 2018-12-25 用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物 HK1257363A1 (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39352210P	2010-10-15	2010-10-15
US201161492054P	2011-06-01	2011-06-01

Publications (1)

Publication Number	Publication Date
HK1257363A1 true HK1257363A1 (zh)	2019-10-18

Family

ID=45938737

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK16100950.0A HK1212914A1 (zh)	2010-10-15	2016-01-28	用於抑制聚合酶的吡咯並嘧啶衍生物
HK18116571.3A HK1257363A1 (zh)	2010-10-15	2018-12-25	用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HK16100950.0A HK1212914A1 (zh)	2010-10-15	2016-01-28	用於抑制聚合酶的吡咯並嘧啶衍生物

Country Status (24)

Country	Link
US (6)	US20130331404A1 (zh)
EP (3)	EP3345605B1 (zh)
JP (2)	JP5902698B2 (zh)
KR (1)	KR101850925B1 (zh)
CN (1)	CN103429245B (zh)
AU (2)	AU2011315902B2 (zh)
BR (1)	BR112013009029B1 (zh)
CA (1)	CA2813783C (zh)
CY (1)	CY1119880T1 (zh)
DK (2)	DK2627334T3 (zh)
ES (2)	ES2657687T3 (zh)
HK (2)	HK1212914A1 (zh)
HR (2)	HRP20150487T1 (zh)
HU (1)	HUE036387T2 (zh)
IL (1)	IL225672B (zh)
LT (1)	LT2898885T (zh)
MX (1)	MX348759B (zh)
PL (2)	PL2898885T3 (zh)
PT (2)	PT2898885T (zh)
RS (2)	RS56870B1 (zh)
RU (3)	RU2718690C2 (zh)
SI (2)	SI2898885T1 (zh)
SM (2)	SMT201800064T1 (zh)
WO (1)	WO2012051570A1 (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2280973E (pt)	2008-04-23	2013-02-04	Gilead Sciences Inc	Análogos de carba-nucleósido para tratamento antiviral
CN102596979B (zh)	2009-09-21	2014-12-10	吉里德科学公司	用于制备1’-取代碳核苷类似物的方法和中间体
KR102108864B1 (ko)	2010-07-19	2020-05-12	길리애드 사이언시즈, 인코포레이티드	부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
MX2013000744A (es)	2010-07-22	2013-03-07	Gilead Sciences Inc	Metodos y compuestos para tratar infecciones virales por paramyxoviridae.
RU2718690C2 (ru) *	2010-10-15	2020-04-13	БАЙОКРИСТ ФАРМАСЬЮТИКАЛЗ, ИНК. (э ЮЭс корпорейшн)	Способы и композиции для ингибирования полимеразы
AR090699A1 (es) *	2012-04-18	2014-12-03	Biocryst Pharm Inc	Compuestos inhibidores de la actividad de la arn polimerasa viral
EP3251674A3 (en) *	2012-11-16	2018-02-21	BioCryst Pharmaceuticals, Inc.	Antiviral azasugar-containing nucleosides
JP6417568B2 (ja) *	2013-05-14	2018-11-07	バイオクリストファーマスーティカルズ，インコーポレイテッドＢｉｏｃｒｙｓｔＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	抗インフルエンザ組成物及び方法
TWI678369B (zh) *	2014-07-28	2019-12-01	美商基利科學股份有限公司	用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
TWI687432B (zh)	2014-10-29	2020-03-11	美商基利科學股份有限公司	絲狀病毒科病毒感染之治療
CN104513249B (zh) *	2014-12-26	2016-08-31	苏州明锐医药科技有限公司	抗埃博拉病毒药物bcx4430的制备方法
SG10202001878WA (en)	2015-09-16	2020-04-29	Gilead Sciences Inc	Methods for treating arenaviridae and coronaviridae virus infections
WO2017155886A1 (en) *	2016-03-06	2017-09-14	Biocryst Pharmaceuticals, Inc.	Methods and compositions for treatment of zika virus infection
DE102016002873A1 (de)	2016-03-09	2016-05-25	Heinz Kiefer	Zellnachweisverfahren und Screeningverfahren von Stoffbibliotheken zur Identifizierung von Einzelstoffen, die im Falle einer bioterroristischen Bedrohung gegen Mischungen synthetischer Viren wirksam sind
US10682368B2 (en)	2017-03-14	2020-06-16	Gilead Sciences, Inc.	Methods of treating feline coronavirus infections
JP2020518578A (ja)	2017-05-01	2020-06-25	ギリアードサイエンシーズ，インコーポレイテッド	（Ｓ）−２−エチルブチル２−（（（Ｓ）−（（（２Ｒ，３Ｓ，４Ｒ，５Ｒ）−５−（４−アミノピロロ［２，１−ｆ］［１，２，４］トリアジン−７−イル）−５−シアノ−３，４−ジヒドロキシテトラヒドロフラン−２−イル）メトキシ）（フェノキシ）ホスホリル）アミノ）プロパノエートの結晶形態
US10675296B2 (en)	2017-07-11	2020-06-09	Gilead Sciences, Inc.	Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
WO2021007283A1 (en) *	2019-07-09	2021-01-14	Regents Of The University Of Minnesota	Potentiation of antiviral nucleobases as rna virus therapy
JP2023512656A (ja)	2020-01-27	2023-03-28	ギリアードサイエンシーズ，インコーポレイテッド	ＳＡＲＳＣｏＶ－２感染を治療するための方法
JP7554841B2 (ja)	2020-03-12	2024-09-20	ギリアードサイエンシーズ，インコーポレイテッド	１’－シアノヌクレオシドを調製する方法
US11701372B2 (en)	2020-04-06	2023-07-18	Gilead Sciences, Inc.	Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs
WO2021207386A1 (en) *	2020-04-07	2021-10-14	Biocryst Pharmaceuticals, Inc.	Methods, compositions, and dosing regimens for treatment of sars-cov-2 infections
WO2021243157A1 (en)	2020-05-29	2021-12-02	Gilead Sciences, Inc.	Remdesivir treatment methods
EP4172160A2 (en)	2020-06-24	2023-05-03	Gilead Sciences, Inc.	1'-cyano nucleoside analogs and uses thereof
HRP20240733T1 (hr)	2020-08-27	2024-08-30	Gilead Sciences, Inc.	Spojevi i postupci za liječenje virusnih infekcija
US20240285557A1 (en) *	2021-06-25	2024-08-29	Industry Foundation Of Chonnam National University	Pharmaceutical composition comprising lipase inhibitor for treatment or treatment of rna viral infections
EP4387733A1 (en)	2021-08-17	2024-06-26	Southwest Research Institute	Inhibitors for coronavirus
CN115925640B (zh) *	2021-08-23	2025-03-28	中国人民解放军军事科学院军事医学研究院	((3-氨甲酰-5-氟吡嗪-2-基)氧基)甲基异丁酸酯及其制备方法和应用
WO2023167944A1 (en)	2022-03-02	2023-09-07	Gilead Sciences, Inc.	Compounds and methods for treatment of viral infections
CN118359621A (zh) *	2024-04-16	2024-07-19	上海陶术生物科技有限公司	加利司伟及加利司伟中间体的制备方法和相应的加利司伟中间体
CN118359622A (zh) *	2024-04-16	2024-07-19	上海陶术生物科技有限公司	加利司伟中间体的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9520364D0 (en) *	1995-10-05	1995-12-06	Chiroscience Ltd	Compouundds
US5985848A (en)	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
US6228741B1 (en)	1998-01-13	2001-05-08	Texas Instruments Incorporated	Method for trench isolation of semiconductor devices
US7388002B2 (en)	2001-11-14	2008-06-17	Biocryst Pharmaceuticals, Inc.	Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
US7098334B2 (en)	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
WO2003100009A2 (en) *	2002-05-23	2003-12-04	Biocryst Pharmaceuticals, Inc.	Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
WO2006002231A1 (en) *	2004-06-22	2006-01-05	Biocryst Pharmaceuticals, Inc.	Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
US7514410B2 (en) *	2005-03-29	2009-04-07	Biocryst Pharmaceuticals, Inc.	Hepatitis C therapies
US20090227637A1 (en) *	2005-12-15	2009-09-10	Olaf Weber	Diaryl ureas for treating virus infections
ES2362805T3 (es)	2006-09-07	2011-07-13	Industrial Research Limited	Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
KR20090094800A (ko)	2006-09-11	2009-09-08	써던 리서취 인스티튜트	아졸 뉴클레오시드 및 알엔에이와 디엔에이 바이러스성 폴리머라제 억제제로의 이용
TW200942243A (en)	2008-03-05	2009-10-16	Biocryst Pharm Inc	Antiviral therapeutic agents
RU2718690C2 (ru) *	2010-10-15	2020-04-13	БАЙОКРИСТ ФАРМАСЬЮТИКАЛЗ, ИНК. (э ЮЭс корпорейшн)	Способы и композиции для ингибирования полимеразы
KR20130126912A (ko) *	2010-11-11	2013-11-21	레드엑스 파마 리미티드	약물 유도체
AR090699A1 (es)	2012-04-18	2014-12-03	Biocryst Pharm Inc	Compuestos inhibidores de la actividad de la arn polimerasa viral

2011
- 2011-10-14 RU RU2016134401A patent/RU2718690C2/ru active
- 2011-10-14 AU AU2011315902A patent/AU2011315902B2/en active Active
- 2011-10-14 SI SI201131383T patent/SI2898885T1/en unknown
- 2011-10-14 PL PL14198125T patent/PL2898885T3/pl unknown
- 2011-10-14 RS RS20180135A patent/RS56870B1/sr unknown
- 2011-10-14 PL PL11833515T patent/PL2627334T3/pl unknown
- 2011-10-14 DK DK11833515.7T patent/DK2627334T3/en active
- 2011-10-14 PT PT141981258T patent/PT2898885T/pt unknown
- 2011-10-14 DK DK14198125.8T patent/DK2898885T3/en active
- 2011-10-14 BR BR112013009029-4A patent/BR112013009029B1/pt active IP Right Grant
- 2011-10-14 SM SM20180064T patent/SMT201800064T1/it unknown
- 2011-10-14 RS RS20150369A patent/RS54072B1/en unknown
- 2011-10-14 MX MX2013003938A patent/MX348759B/es active IP Right Grant
- 2011-10-14 EP EP17196354.9A patent/EP3345605B1/en active Active
- 2011-10-14 WO PCT/US2011/056421 patent/WO2012051570A1/en active Application Filing
- 2011-10-14 HU HUE14198125A patent/HUE036387T2/hu unknown
- 2011-10-14 RU RU2013121794/15A patent/RU2599013C2/ru active
- 2011-10-14 SI SI201130489T patent/SI2627334T1/sl unknown
- 2011-10-14 JP JP2013534046A patent/JP5902698B2/ja active Active
- 2011-10-14 PT PT118335157T patent/PT2627334E/pt unknown
- 2011-10-14 EP EP11833515.7A patent/EP2627334B1/en active Active
- 2011-10-14 CA CA2813783A patent/CA2813783C/en active Active
- 2011-10-14 KR KR1020137012318A patent/KR101850925B1/ko active Active
- 2011-10-14 ES ES14198125.8T patent/ES2657687T3/es active Active
- 2011-10-14 ES ES11833515.7T patent/ES2536831T3/es active Active
- 2011-10-14 EP EP14198125.8A patent/EP2898885B1/en active Active
- 2011-10-14 CN CN201180059786.9A patent/CN103429245B/zh active Active
- 2011-10-14 LT LTEP14198125.8T patent/LT2898885T/lt unknown
- 2011-10-14 US US13/879,110 patent/US20130331404A1/en not_active Abandoned
2013
- 2013-04-10 IL IL225672A patent/IL225672B/en active IP Right Grant
2014
- 2014-11-03 US US14/531,471 patent/US9492452B2/en active Active
2015
- 2015-05-06 HR HRP20150487TT patent/HRP20150487T1/hr unknown
- 2015-06-25 SM SM201500148T patent/SMT201500148B/xx unknown
2016
- 2016-01-28 HK HK16100950.0A patent/HK1212914A1/zh unknown
- 2016-03-10 JP JP2016046875A patent/JP2016135790A/ja not_active Withdrawn
- 2016-10-28 US US15/337,320 patent/US10022375B2/en active Active
2017
- 2017-01-24 AU AU2017200471A patent/AU2017200471B2/en active Active
2018
- 2018-02-02 CY CY20181100131T patent/CY1119880T1/el unknown
- 2018-02-06 HR HRP20180220TT patent/HRP20180220T1/hr unknown
- 2018-06-20 US US16/013,059 patent/US10420769B2/en active Active
- 2018-12-25 HK HK18116571.3A patent/HK1257363A1/zh unknown
2019
- 2019-08-16 US US16/543,079 patent/US11173159B2/en active Active
2020
- 2020-03-17 RU RU2020111042A patent/RU2020111042A/ru unknown
2021
- 2021-10-21 US US17/506,836 patent/US20220040190A1/en active Pending

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Publication number	Publication date
PT2898885T (pt)	2018-02-05
EP3345605A1 (en)	2018-07-11
HRP20180220T1 (hr)	2018-03-09
CY1119880T1 (el)	2018-06-27
HUE036387T2 (hu)	2018-07-30
RU2016134401A3 (zh)	2020-01-24
AU2011315902B2 (en)	2016-11-17
IL225672A0 (en)	2013-06-27
EP2898885A1 (en)	2015-07-29
IL225672B (en)	2019-02-28
EP2627334A1 (en)	2013-08-21
RU2718690C2 (ru)	2020-04-13
US10022375B2 (en)	2018-07-17
MX348759B (es)	2017-06-28
US9492452B2 (en)	2016-11-15
SMT201500148B (it)	2015-09-07
EP2627334A4 (en)	2014-04-16
JP2016135790A (ja)	2016-07-28
US20130331404A1 (en)	2013-12-12
EP3345605B1 (en)	2019-11-20
RS56870B1 (sr)	2018-04-30
RU2013121794A (ru)	2014-11-20
AU2017200471B2 (en)	2018-04-12
PT2627334E (pt)	2015-07-07
DK2627334T3 (en)	2015-05-18
PL2898885T3 (pl)	2018-04-30
US10420769B2 (en)	2019-09-24
US20150051230A1 (en)	2015-02-19
KR101850925B1 (ko)	2018-04-20
EP2627334B1 (en)	2015-04-29
ES2657687T3 (es)	2018-03-06
HK1212914A1 (zh)	2016-06-24
AU2017200471A1 (en)	2017-02-23
BR112013009029A2 (pt)	2018-06-19
SI2627334T1 (sl)	2015-08-31
RU2020111042A (ru)	2021-09-17
US20220040190A1 (en)	2022-02-10
DK2898885T3 (en)	2018-02-05
RU2016134401A (ru)	2018-12-10
WO2012051570A1 (en)	2012-04-19
CN103429245A (zh)	2013-12-04
JP2013544788A (ja)	2013-12-19
SMT201800064T1 (it)	2018-03-08
ES2536831T3 (es)	2015-05-29
EP2898885B1 (en)	2017-11-22
SI2898885T1 (en)	2018-03-30
LT2898885T (lt)	2018-02-26
CA2813783A1 (en)	2012-04-19
JP5902698B2 (ja)	2016-04-13
KR20140040676A (ko)	2014-04-03
HRP20150487T1 (hr)	2015-08-28
RU2599013C2 (ru)	2016-10-10
US20170042901A1 (en)	2017-02-16
PL2627334T3 (pl)	2015-08-31
CA2813783C (en)	2019-01-22
BR112013009029B1 (pt)	2021-06-29
US20190374544A1 (en)	2019-12-12
AU2011315902A1 (en)	2013-05-30
RS54072B1 (en)	2015-10-30
MX2013003938A (es)	2013-07-05
CN103429245B (zh)	2016-10-05
US20180360836A1 (en)	2018-12-20
US11173159B2 (en)	2021-11-16

Publication	Publication Date	Title
HK1257363A1 (zh)	2019-10-18	用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物
HK1198698A1 (zh)	2015-05-29	取代的增環嘧啶及其用途
ZA201305495B (en)	2016-07-27	Compounds and their use as bace inhibitors
HK1179953A1 (zh)	2013-10-11	吡咯並嘧啶化合物及其用途
IL219646A0 (en)	2012-07-31	Novelnaphthyridine derivatives and the use thereof as kinase inhibitors
AP3849A (en)	2016-09-30	Use of inhibitors of the activity or function of pi3k
ZA201204793B (en)	2013-02-27	Substituted naphthyridines and their use as syk kinase inhibitors
ZA201400153B (en)	2015-12-23	Pyridazinone compounds and their use as daao inhibitors
GB201016880D0 (en)	2010-11-17	Phosphodiesterase inhibitors
GB201111705D0 (en)	2011-08-24	Compounds and their use
ZA201208895B (en)	2014-01-29	Bicyclic compound derivatives and their use as acc inhibitors
ZA201300036B (en)	2013-09-25	Banzamide derivatives and their use as hsp90 inhibitors
AP2013006947A0 (en)	2013-06-30	Compounds and their use
ZA201207089B (en)	2014-03-26	Adenosine compounds and their use thereof
GB201114448D0 (en)	2011-10-05	Compounds and their use
GB201104444D0 (en)	2011-04-27	Compounds and their use
GB201000305D0 (en)	2010-02-24	Compounds and their use
GB201000308D0 (en)	2010-02-24	Compounds and their use
GB201000307D0 (en)	2010-02-24	Compounds and their use
GB201000309D0 (en)	2010-02-24	Compounds and their use
GB201002337D0 (en)	2010-03-31	Compounds and their use
GB201005511D0 (en)	2010-05-19	Compounds and their use
GB201017822D0 (en)	2010-12-01	Compounds and their use
GB201018028D0 (en)	2010-12-08	Compounds and their use
GB201020848D0 (en)	2011-01-26	Compounds and their use