[go: up one dir, main page]

HK1254775A1 - 寡糖的大規模酶合成的方法 - Google Patents

寡糖的大規模酶合成的方法

Info

Publication number
HK1254775A1
HK1254775A1 HK18113821.8A HK18113821A HK1254775A1 HK 1254775 A1 HK1254775 A1 HK 1254775A1 HK 18113821 A HK18113821 A HK 18113821A HK 1254775 A1 HK1254775 A1 HK 1254775A1
Authority
HK
Hong Kong
Prior art keywords
oligosaccharides
large scale
enzymatic synthesis
scale enzymatic
synthesis
Prior art date
Application number
HK18113821.8A
Other languages
English (en)
Inventor
翁啟惠
吳宗益
蔡宗義
Original Assignee
中央研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 中央研究院 filed Critical 中央研究院
Publication of HK1254775A1 publication Critical patent/HK1254775A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01006—Galactokinase (2.7.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07009—UTP-glucose-1-phosphate uridylyltransferase (2.7.7.9), i.e. UDP-glucose-pyrophosphorylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/0701—UTP--hexose-1-phosphate uridylyltransferase (2.7.7.10)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK18113821.8A 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法 HK1254775A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261684974P 2012-08-20 2012-08-20

Publications (1)

Publication Number Publication Date
HK1254775A1 true HK1254775A1 (zh) 2019-07-26

Family

ID=50100297

Family Applications (6)

Application Number Title Priority Date Filing Date
HK15108043.3A HK1207668A1 (zh) 2012-08-20 2015-08-19 寡糖的大規模酶合成的方法
HK18113819.2A HK1254773A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113818.3A HK1254772A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113821.8A HK1254775A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113822.7A HK1254776A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113820.9A HK1254774A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK15108043.3A HK1207668A1 (zh) 2012-08-20 2015-08-19 寡糖的大規模酶合成的方法
HK18113819.2A HK1254773A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113818.3A HK1254772A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK18113822.7A HK1254776A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法
HK18113820.9A HK1254774A1 (zh) 2012-08-20 2018-10-30 寡糖的大規模酶合成的方法

Country Status (11)

Country Link
US (2) US9340812B2 (zh)
EP (1) EP2885416B8 (zh)
JP (5) JP6125637B2 (zh)
KR (1) KR101685628B1 (zh)
CN (6) CN108504703B (zh)
AU (3) AU2016206315B2 (zh)
CA (4) CA3052909C (zh)
ES (1) ES2974096T3 (zh)
HK (6) HK1207668A1 (zh)
TW (5) TWI563091B (zh)
WO (1) WO2014031602A1 (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
EP2318832B1 (en) 2008-07-15 2013-10-09 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US9782476B2 (en) 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
CN106459920B (zh) 2014-01-16 2020-10-30 中央研究院 治疗及检测癌症的组合物及方法
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI797430B (zh) 2014-03-27 2023-04-01 中央研究院 反應性標記化合物及其用途
AU2015267047A1 (en) 2014-05-27 2017-01-05 Academia Sinica Anti-CD20 glycoantibodies and uses thereof
TWI717319B (zh) 2014-05-27 2021-02-01 中央研究院 得自類桿菌屬之岩藻糖苷酶及其用途
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA2950440A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-her2 glycoantibodies and uses thereof
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
ES2820303T3 (es) 2014-08-22 2021-04-20 Academia Sinica Conjugados de glicanos y uso de los mismos
JP6899321B2 (ja) 2014-09-08 2021-07-07 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 糖脂質を使用するヒトｉＮＫＴ細胞活性化
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
KR102691114B1 (ko) 2015-01-24 2024-08-01 아카데미아 시니카 신규한 글리칸 콘주게이트 및 이를 사용하는 방법
TWI710571B (zh) 2015-01-24 2020-11-21 中央研究院 腫瘤標記及其使用方法
AU2016211176B2 (en) 2015-01-30 2021-01-28 Academia Sinica; Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2017231749A1 (en) 2016-03-08 2018-09-20 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
KR102588027B1 (ko) 2016-08-22 2023-10-12 초 파마 인크. 항체, 결합 단편 및 사용 방법
CN113574143B (zh) 2019-03-14 2022-10-18 日油株式会社 润滑油用添加剂、润滑油用添加剂组合物及含有该添加剂或添加剂组合物的润滑油组合物
CN110195043A (zh) * 2019-05-15 2019-09-03 武汉格莱利生物科技有限公司 一种高水溶性的cgta酶及其制备方法和应用
WO2021093022A1 (zh) * 2019-11-15 2021-05-20 中粮营养健康研究院有限公司 重组大肠杆菌系统及其构建方法和其在合成α-1,2-岩藻糖基化寡糖中的应用
US20240287564A1 (en) * 2021-06-07 2024-08-29 The University Of British Columbia Acholetin biopolymers and methods for enzymatic synthesis
CN115710594B (zh) * 2021-08-23 2024-06-28 中国科学院上海药物研究所 一种合成尿苷二磷酸-6-叠氮-d-半乳糖的方法
TWI828311B (zh) * 2021-09-11 2024-01-01 中央研究院 合成化合物、包含該合成化合物的套組及其用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668505B2 (en) * 1991-03-18 1996-05-09 Scripps Research Institute, The Oligosaccharide enzyme substrates and inhibitors: methods and compositions
US6319695B1 (en) * 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
US5369017A (en) * 1994-02-04 1994-11-29 The Scripps Research Institute Process for solid phase glycopeptide synthesis
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
CN100342025C (zh) * 1996-09-17 2007-10-10 协和发酵工业株式会社 糖核苷酸类及复合糖类的制备方法
US7244601B2 (en) * 1997-12-15 2007-07-17 National Research Council Of Canada Fusion proteins for use in enzymatic synthesis of oligosaccharides
US6194178B1 (en) * 1998-09-03 2001-02-27 Synsorb Biotech Inc. Method for the production of sialylated oligosaccharides
MXPA01004982A (es) * 1998-11-18 2004-09-27 Neose Technologies Inc Manufactura de bajo costo de oligosacaridos.
AU1415401A (en) * 1999-11-19 2001-06-04 Kyowa Hakko Kogyo Co. Ltd. Glmu polypeptide and dna encoding the polypeptide
JP4619500B2 (ja) 2000-09-08 2011-01-26 生化学工業株式会社 β１，３−Ｎ−アセチルガラクトサミン転移酵素の製造方法
US20020150968A1 (en) * 2001-01-10 2002-10-17 Wang Peng G. Glycoconjugate and sugar nucleotide synthesis using solid supports
JP2002335988A (ja) * 2001-05-22 2002-11-26 Yamasa Shoyu Co Ltd オリゴ糖の製造法
JP5236189B2 (ja) * 2003-12-05 2013-07-17 チルドレンズ ホスピタル メディカル センター オリゴ糖組成物および感染症の治療における該組成物の使用
US20070202578A1 (en) * 2005-08-26 2007-08-30 Centre National De La Recherche Scientifique (Cnrs) Production of globosides oligosaccharides using metabolically engineered microorganisms
US8198045B2 (en) * 2006-04-19 2012-06-12 Biogenerix Ag Expression of O-glycosylated therapeutic proteins in prokaryotic microorganisms
KR100888513B1 (ko) * 2006-12-15 2009-03-12 주식회사 진켐 신규 ｎ―아세틸글루코사민―２―에피머라아제 및 이를이용한 ｃｍｐ―ｎ―아세틸뉴라민산의 제조방법
CA2712556A1 (en) * 2007-01-18 2008-07-24 Glykos Finland Ltd Novel carbohydrate from human cells and methods for analysis and modification thereof
ES2555220T3 (es) 2009-03-27 2015-12-29 Academia Sinica Donantes de sialil-fosfato selectivos para la preparación de sialósidos y matrices de sialósidos para la detección del virus de la gripe
JP5464578B2 (ja) 2009-07-31 2014-04-09 独立行政法人産業技術総合研究所 Ｓｓｅａ系新規糖鎖化合物
CN102443598A (zh) * 2010-10-15 2012-05-09 天津赛科瑞德生物科技有限公司 利用糖基转移酶大量制备Globo系列抗原的方法
CN102443597A (zh) * 2010-10-15 2012-05-09 天津赛科瑞德生物科技有限公司 糖核苷酸的酶法制备

Also Published As

Publication number Publication date
CN108588151A (zh) 2018-09-28
AU2018200094A1 (en) 2018-01-25
WO2014031602A1 (en) 2014-02-27
TWI567200B (zh) 2017-01-21
US20140051127A1 (en) 2014-02-20
CN108611384A (zh) 2018-10-02
AU2016206315A1 (en) 2016-08-11
HK1254773A1 (zh) 2019-07-26
TWI510627B (zh) 2015-12-01
CN108504703A (zh) 2018-09-07
CN108611384B (zh) 2022-02-25
AU2016206315B2 (en) 2017-12-14
CA2882294C (en) 2019-10-22
CA3052909A1 (en) 2014-02-27
CA3129035C (en) 2023-03-07
CA2882294A1 (en) 2014-02-27
JP2020054389A (ja) 2020-04-09
AU2013305937A1 (en) 2015-02-19
TW201602354A (zh) 2016-01-16
TWI563092B (en) 2016-12-21
JP2019047822A (ja) 2019-03-28
CA3129035A1 (en) 2014-02-27
JP2017118883A (ja) 2017-07-06
EP2885416A1 (en) 2015-06-24
EP2885416A4 (en) 2016-05-18
JP6925658B2 (ja) 2021-08-25
TW201602351A (zh) 2016-01-16
TW201602352A (zh) 2016-01-16
EP2885416B8 (en) 2024-02-14
HK1254774A1 (zh) 2019-07-26
AU2018200094B2 (en) 2019-02-14
CN104822837B (zh) 2018-06-05
CN104822837A (zh) 2015-08-05
CN108504702B (zh) 2021-05-04
TW201602353A (zh) 2016-01-16
US20160230201A1 (en) 2016-08-11
JP6462756B2 (ja) 2019-01-30
TWI573876B (zh) 2017-03-11
CA3187148A1 (en) 2014-02-27
TW201418467A (zh) 2014-05-16
JP6125637B2 (ja) 2017-05-10
AU2019203313A1 (en) 2019-05-30
CN108546643A (zh) 2018-09-18
AU2019203313B2 (en) 2020-04-30
JP2021168693A (ja) 2021-10-28
ES2974096T3 (es) 2024-06-25
HK1254772A1 (zh) 2019-07-26
JP7376136B2 (ja) 2023-11-08
CN108504702A (zh) 2018-09-07
CN108504703B (zh) 2021-06-29
CN108546643B (zh) 2022-02-25
CA3052909C (en) 2021-10-19
JP6647382B2 (ja) 2020-02-14
US9340812B2 (en) 2016-05-17
JP2015529461A (ja) 2015-10-08
TWI563091B (en) 2016-12-21
EP2885416B1 (en) 2024-01-03
CN108588151B (zh) 2022-05-13
HK1254776A1 (zh) 2019-07-26
HK1207668A1 (zh) 2016-02-05
KR101685628B1 (ko) 2016-12-12
KR20150042859A (ko) 2015-04-21

Similar Documents

Publication Publication Date Title
HK1254774A1 (zh) 寡糖的大規模酶合成的方法
IL261527A (en) Conversion of biomass
IL262055B (en) Synthesis of lactams
HK1213599A1 (zh) 用於製備葡聚糖聚合物的葡糖基轉移酶
EP2686330A4 (en) SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES
SG11201405573WA (en) Production of graphene
PT2875062T (pt) Processo de síntese de poliarilétercetonas
HK1207078A1 (zh) 酶的抑制
ZA201500209B (en) Supercritical hydrolysis of biomass
IL228604A0 (en) Synthesis of 5-azacytidine
EP2900829A4 (en) glycoconjugate synthesis
EP2864491A4 (en) ENZYMES AND METHODS FOR STYRENE SYNTHESIS
IL235556A0 (en) Enzymatic synthesis of l-nucleic acid
ZA201503913B (en) Synthesis of zsm-5
GB201004096D0 (en) Production of polyhydroalkanoates
HK1208553A1 (zh) 原產地鑒定
IL223926A0 (en) Synthesis of cyclopentaquinazolines
HK1202876A1 (zh) 改進的合成
GB201012036D0 (en) Synthesis of new carbohydrate derivatives
AU2012902119A0 (en) Improved synthesis
GB201204338D0 (en) Dissolution of biomass
GB201205044D0 (en) Improved modelling of dynamic systems
GB201220859D0 (en) Enzyme and methods of enzymatic synthesis
GB201212879D0 (en) Novel sound product
AU2011901933A0 (en) Synthesis of pharmacosiderite minerals