HK1247922A1 - 用於治療癌症的吲哚胺2,3-雙加氧酶抑制劑 - Google Patents
用於治療癌症的吲哚胺2,3-雙加氧酶抑制劑Info
- Publication number
- HK1247922A1 HK1247922A1 HK18107390.1A HK18107390A HK1247922A1 HK 1247922 A1 HK1247922 A1 HK 1247922A1 HK 18107390 A HK18107390 A HK 18107390A HK 1247922 A1 HK1247922 A1 HK 1247922A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- indoleamine
- dioxygenase
- inhibitors
- cancer
- treatment
- Prior art date
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- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
LT3105218T (lt) | 2014-02-13 | 2019-12-10 | Incyte Corp | Ciklopropilaminai kaip lsd1 inhibitoriai |
EA201691594A1 (ru) | 2014-02-13 | 2017-02-28 | Инсайт Корпорейшн | Циклопропиламины в качестве ингибиторов lsd1 |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
EP3626720A1 (en) | 2015-04-03 | 2020-03-25 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
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DK3334709T3 (da) | 2015-08-12 | 2025-02-03 | Incyte Holdings Corp | Salte af en lsd1-hæmmer |
BR112018005870A2 (pt) * | 2015-09-24 | 2018-10-16 | Glaxosmithkline Ip No 2 Ltd | composto, e, método de prevenção e/ou tratamento do hiv. |
EP3558966A1 (en) * | 2016-12-20 | 2019-10-30 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
US10899754B2 (en) * | 2016-12-20 | 2021-01-26 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
PT3559009T (pt) | 2016-12-22 | 2021-05-04 | Calithera Biosciences Inc | Composições e métodos para inibir a atividade da arginase |
CN110191709A (zh) | 2017-01-17 | 2019-08-30 | 德州大学系统董事会 | 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物 |
US20200188482A1 (en) * | 2017-04-28 | 2020-06-18 | The Brigham And Women`S Hospital, Inc. | Targeting gamma-delta t cells in obesity and cachexia |
AU2018263921A1 (en) | 2017-05-03 | 2019-12-05 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
WO2018219309A1 (zh) * | 2017-06-02 | 2018-12-06 | 沈阳化工研究院有限公司 | 一种芳乙烯衍生物及其应用 |
US20210139467A1 (en) * | 2017-06-28 | 2021-05-13 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
CN107325019B (zh) * | 2017-08-11 | 2019-11-22 | 石河子大学 | 芳胺基苯甲酰胺类化合物及n-芳基-芳胺基苯甲酰胺类化合物的制备方法 |
AU2018321291A1 (en) | 2017-08-21 | 2020-03-26 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
WO2019078968A2 (en) * | 2017-10-18 | 2019-04-25 | Angex Pharmaceutical, Inc. | CYCLIC COMPOUNDS AS IMMUNOMODULATORS |
CN109836356B (zh) * | 2017-11-24 | 2022-03-08 | 沈阳化工研究院有限公司 | 一种芳甲醚衍生物及其应用 |
US11524943B1 (en) | 2017-12-06 | 2022-12-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
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