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HK1245764A1 - 3-取代的5-氨基-6h-噻唑並[4，5-d]嘧啶-2，7-二酮化合物 - Google Patents

3-取代的5-氨基-6h-噻唑並[4，5-d]嘧啶-2，7-二酮化合物

Info

Publication number
HK1245764A1
HK1245764A1 HK18104912.7A HK18104912A HK1245764A1 HK 1245764 A1 HK1245764 A1 HK 1245764A1 HK 18104912 A HK18104912 A HK 18104912A HK 1245764 A1 HK1245764 A1 HK 1245764A1
Authority
HK
Hong Kong
Prior art keywords
thiazolo
pyrimidine
amino
substituted
dione compounds
Prior art date
Application number
HK18104912.7A
Other languages
English (en)
Inventor
Dongdong Chen
Song Feng
Lu Gao
Chao Li
Baoxia Wang
Lisha Wang
Hongying Yun
Xiufang Zheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1245764A1 publication Critical patent/HK1245764A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK18104912.7A 2014-12-08 2018-04-16 3-取代的5-氨基-6h-噻唑並[4，5-d]嘧啶-2，7-二酮化合物 HK1245764A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014093224 2014-12-08
CN2015086987 2015-08-14

Publications (1)

Publication Number Publication Date
HK1245764A1 true HK1245764A1 (zh) 2018-08-31

Family

ID=54771116

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104912.7A HK1245764A1 (zh) 2014-12-08 2018-04-16 3-取代的5-氨基-6h-噻唑並[4，5-d]嘧啶-2，7-二酮化合物

Country Status (31)

Country Link
US (4) US9441008B2 (zh)
EP (1) EP3230298B1 (zh)
JP (1) JP6817217B2 (zh)
KR (2) KR102557560B1 (zh)
CN (2) CN106164079B (zh)
AU (1) AU2015359692B2 (zh)
BR (1) BR112017011941B1 (zh)
CA (1) CA2963717C (zh)
CL (1) CL2017001426A1 (zh)
CR (1) CR20170237A (zh)
DK (1) DK3230298T3 (zh)
EA (1) EA038744B1 (zh)
ES (1) ES2864223T3 (zh)
HK (1) HK1245764A1 (zh)
HR (1) HRP20210454T1 (zh)
HU (1) HUE053704T2 (zh)
IL (1) IL251285B (zh)
LT (1) LT3230298T (zh)
MA (1) MA41134B1 (zh)
MX (1) MX379474B (zh)
MY (1) MY194002A (zh)
PE (1) PE20170679A1 (zh)
PH (1) PH12017501061B1 (zh)
PL (1) PL3230298T3 (zh)
PT (1) PT3230298T (zh)
RS (1) RS61612B1 (zh)
SG (1) SG11201704512PA (zh)
SI (1) SI3230298T1 (zh)
TW (1) TWI733656B (zh)
UA (1) UA124184C2 (zh)
WO (1) WO2016091698A1 (zh)

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AU2015359692A1 (en) 2017-04-06
US20160194350A1 (en) 2016-07-07
DK3230298T3 (da) 2021-03-22
CN107445980B (zh) 2021-04-20
LT3230298T (lt) 2021-04-12
MA41134B1 (fr) 2021-03-31
IL251285B (en) 2021-10-31
EP3230298B1 (en) 2021-01-20
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