HK1243714A1 - 製備取代的核苷類似物的方法 - Google Patents
製備取代的核苷類似物的方法Info
- Publication number
- HK1243714A1 HK1243714A1 HK18103109.2A HK18103109A HK1243714A1 HK 1243714 A1 HK1243714 A1 HK 1243714A1 HK 18103109 A HK18103109 A HK 18103109A HK 1243714 A1 HK1243714 A1 HK 1243714A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- nucleoside analogs
- substituted nucleoside
- preparing substituted
- preparing
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462069770P | 2014-10-28 | 2014-10-28 | |
| PCT/US2015/057405 WO2016069489A1 (en) | 2014-10-28 | 2015-10-26 | Methods of preparing substituted nucleoside analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1243714A1 true HK1243714A1 (zh) | 2018-07-20 |
Family
ID=55791453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18103109.2A HK1243714A1 (zh) | 2014-10-28 | 2018-03-05 | 製備取代的核苷類似物的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9908914B2 (zh) |
| EP (1) | EP3212657A4 (zh) |
| KR (1) | KR20170073649A (zh) |
| CN (1) | CN107108681B (zh) |
| HK (1) | HK1243714A1 (zh) |
| TW (1) | TWI671310B (zh) |
| WO (1) | WO2016069489A1 (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA035493B1 (ru) | 2011-12-22 | 2020-06-25 | Янссен Байофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| JP6284547B2 (ja) | 2012-12-21 | 2018-02-28 | アリオス バイオファーマ インク． | 置換ヌクレオシド、置換ヌクレオチドおよびそれらの類似体 |
| AU2013361193B2 (en) | 2012-12-21 | 2018-05-24 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TW201532606A (zh) | 2013-04-05 | 2015-09-01 | Alios Biopharma Inc | 使用化合物之組合治療ｃ型肝炎病毒感染 |
| TW201542578A (zh) * | 2013-06-26 | 2015-11-16 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
| MX2015017556A (es) | 2013-06-26 | 2016-05-09 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos. |
| EA201690526A1 (ru) | 2013-10-11 | 2017-02-28 | Алиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| SG11201610259SA (en) * | 2014-06-24 | 2017-01-27 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
| LT3160476T (lt) | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9908914B2 (en) * | 2014-10-28 | 2018-03-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| EP4493573A1 (en) | 2022-03-15 | 2025-01-22 | Rome Therapeutics, Inc. | Compounds and methods for treating disease |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0407374A (pt) * | 2003-02-19 | 2006-01-10 | Univ Yale | Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv |
| SG174364A1 (en) | 2009-03-20 | 2011-10-28 | Alios Biopharma Inc | Substituted nucleoside and nucleotide analogs |
| KR101701510B1 (ko) | 2010-07-09 | 2017-02-01 | 엘지이노텍 주식회사 | 발광소자 |
| US20120070411A1 (en) | 2010-09-22 | 2012-03-22 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| US8871737B2 (en) | 2010-09-22 | 2014-10-28 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| WO2012040124A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US8772474B2 (en) | 2010-12-22 | 2014-07-08 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| EA035493B1 (ru) * | 2011-12-22 | 2020-06-25 | Янссен Байофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142125A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Methods of preparing substituted nucleotide analogs |
| SG11201405351RA (en) | 2012-03-21 | 2014-10-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142159A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| AU2013361193B2 (en) | 2012-12-21 | 2018-05-24 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| JP6284547B2 (ja) | 2012-12-21 | 2018-02-28 | アリオス バイオファーマ インク． | 置換ヌクレオシド、置換ヌクレオチドおよびそれらの類似体 |
| US20150065439A1 (en) | 2013-02-28 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
| WO2014164533A1 (en) | 2013-03-11 | 2014-10-09 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
| TW201532606A (zh) | 2013-04-05 | 2015-09-01 | Alios Biopharma Inc | 使用化合物之組合治療ｃ型肝炎病毒感染 |
| MX2015017556A (es) * | 2013-06-26 | 2016-05-09 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos. |
| TW201542578A (zh) | 2013-06-26 | 2015-11-16 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
| EA201690526A1 (ru) | 2013-10-11 | 2017-02-28 | Алиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| SG11201610259SA (en) | 2014-06-24 | 2017-01-27 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
| LT3160476T (lt) | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| JP2017525681A (ja) | 2014-07-22 | 2017-09-07 | アリオス バイオファーマ インク． | パラミクソウイルスの治療方法 |
| MA40404A (fr) | 2014-08-05 | 2017-06-14 | Alios Biopharma Inc | Polythérapie pour traiter un paramyxovirus |
| US9908914B2 (en) | 2014-10-28 | 2018-03-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA45925A (fr) | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
| US20180117042A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
-
2015
- 2015-10-26 US US14/923,283 patent/US9908914B2/en active Active
- 2015-10-26 CN CN201580059053.3A patent/CN107108681B/zh not_active Expired - Fee Related
- 2015-10-26 EP EP15855437.8A patent/EP3212657A4/en not_active Withdrawn
- 2015-10-26 WO PCT/US2015/057405 patent/WO2016069489A1/en active Application Filing
- 2015-10-26 KR KR1020177013721A patent/KR20170073649A/ko not_active Ceased
- 2015-10-28 TW TW104135489A patent/TWI671310B/zh not_active IP Right Cessation
-
2018
- 2018-02-26 US US15/905,526 patent/US10519185B2/en not_active Expired - Fee Related
- 2018-03-05 HK HK18103109.2A patent/HK1243714A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3212657A4 (en) | 2018-04-11 |
| WO2016069489A1 (en) | 2016-05-06 |
| CN107108681A (zh) | 2017-08-29 |
| US9908914B2 (en) | 2018-03-06 |
| US20160115190A1 (en) | 2016-04-28 |
| US20180186825A1 (en) | 2018-07-05 |
| TW201625657A (zh) | 2016-07-16 |
| EP3212657A1 (en) | 2017-09-06 |
| CN107108681B (zh) | 2021-04-06 |
| TWI671310B (zh) | 2019-09-11 |
| US10519185B2 (en) | 2019-12-31 |
| KR20170073649A (ko) | 2017-06-28 |
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