HK1223628A1 - β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途 - Google Patents
β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途Info
- Publication number
- HK1223628A1 HK1223628A1 HK16111868.8A HK16111868A HK1223628A1 HK 1223628 A1 HK1223628 A1 HK 1223628A1 HK 16111868 A HK16111868 A HK 16111868A HK 1223628 A1 HK1223628 A1 HK 1223628A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkylcholanic
- ketone
- novel
- preparation
- acid
- Prior art date
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410652460.2A CN105669811B (zh) | 2014-11-17 | 2014-11-17 | 新的7-酮-6β-烷基胆烷酸衍生物在制备奥贝胆酸以及其在医药领域的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1223628A1 true HK1223628A1 (zh) | 2017-08-04 |
Family
ID=56944525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16111868.8A HK1223628A1 (zh) | 2014-11-17 | 2016-10-14 | β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN111944006B (zh) |
| HK (1) | HK1223628A1 (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| SMT202100593T1 (it) | 2015-03-31 | 2021-11-12 | Enanta Pharm Inc | Derivati degli acidi biliari come agonisti di fxr/tgr5 e metodi per il loro uso |
| CN106589039B (zh) * | 2015-10-15 | 2019-12-17 | 苏州朗科生物技术股份有限公司 | 一种奥贝胆酸的制备方法及相关化合物 |
| EP3464316A4 (en) * | 2016-06-01 | 2020-02-19 | Dr. Reddy's Laboratories Ltd. | PROCESS FOR THE PREPARATION OF OBETICHOLIC ACID |
| WO2018010651A1 (zh) * | 2016-07-13 | 2018-01-18 | 江苏恒瑞医药股份有限公司 | 一种奥贝胆酸及其中间体的制备方法 |
| CN106279336A (zh) * | 2016-08-18 | 2017-01-04 | 合肥诺瑞吉医药科技有限公司 | 一种奥贝胆酸的合成方法 |
| CN107936078A (zh) * | 2016-10-13 | 2018-04-20 | 上海科胜药物研发有限公司 | 一种制备奥贝胆酸的新方法 |
| CA3045023A1 (en) * | 2016-11-29 | 2018-06-07 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
| CN108614038B (zh) * | 2016-12-13 | 2022-05-17 | 亚宝药业集团股份有限公司 | 一种测定奥贝胆酸原料药有关物质的方法 |
| CN106749472B (zh) * | 2016-12-30 | 2019-02-22 | 江苏开元医药化工有限公司 | 一种3α-羟基-6α-乙基-7-酮-5β-胆烷-24-酸的制备方法 |
| CN106645497A (zh) * | 2017-01-03 | 2017-05-10 | 山东省药学科学院 | 一种奥贝胆酸及其制剂中有关物质的检测方法 |
| CN108456238A (zh) * | 2017-02-20 | 2018-08-28 | 浙江京新药业股份有限公司 | 奥贝胆酸衍生物及奥贝胆酸的制备方法 |
| AU2018249950B2 (en) * | 2017-04-07 | 2023-09-21 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
| WO2018220513A1 (en) * | 2017-05-31 | 2018-12-06 | Alembic Pharmaceuticals Limited | An improved process for preparation of obeticholic acid |
| CZ201869A3 (cs) * | 2018-02-12 | 2019-09-04 | Farmak, A.S. | Způsob přípravy kyseliny obeticholové |
| CN108680696B (zh) * | 2018-05-15 | 2020-06-30 | 南京正大天晴制药有限公司 | 一种奥贝胆酸起始物料的检测方法 |
| CN111285914B (zh) * | 2018-12-10 | 2023-02-17 | 江西青峰药业有限公司 | 一种奥贝胆酸的制备方法 |
| CN109485686B (zh) * | 2018-12-27 | 2021-08-27 | 重庆华邦胜凯制药有限公司 | 一种提高琥珀酸甲泼尼龙杂质合成中关键中间体6β含量的方法 |
| CN109655571B (zh) * | 2019-01-08 | 2021-07-13 | 丽珠集团新北江制药股份有限公司 | 一种奥贝胆酸的高效液相色谱分析方法 |
| CN111718388A (zh) * | 2019-03-19 | 2020-09-29 | 苏州泽璟生物制药股份有限公司 | 鹅去氧胆酸衍生物的制备方法 |
| CN112898369B (zh) * | 2019-12-04 | 2024-09-17 | 博瑞生物医药（苏州）股份有限公司 | 用于制备奥贝胆酸的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL157816A0 (en) * | 2001-03-12 | 2004-03-28 | Roberto Pellicciari | Steroids as agonists for fxr |
| ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| US20140206657A1 (en) * | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
| CN104876995B (zh) * | 2014-02-27 | 2016-09-07 | 人福医药集团股份公司 | 鹅去氧胆酸衍生物的制备方法 |
| US10166246B2 (en) * | 2014-05-27 | 2019-01-01 | City Of Hope | TGR5 agonist complexes for treating diabetes and cancer |
| LT3626725T (lt) * | 2014-05-29 | 2023-03-10 | Bar Pharmaceuticals S.R.L. | Cholano dariniai skirti naudoti ligų, kurių atsiradimui tarpininkauja fxr ir tgr5/gpbar1, gydymui ir (arba) profilaktikai |
-
2014
- 2014-11-17 CN CN202010731648.1A patent/CN111944006B/zh active Active
- 2014-11-17 CN CN201410652460.2A patent/CN105669811B/zh active Active
-
2016
- 2016-10-14 HK HK16111868.8A patent/HK1223628A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111944006A (zh) | 2020-11-17 |
| CN111944006B (zh) | 2021-12-17 |
| CN105669811A (zh) | 2016-06-15 |
| CN105669811B (zh) | 2020-09-04 |
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