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HK1216184A1 - 種血漿中游離的目標 低頻突變富集測序方法 - Google Patents

種血漿中游離的目標 低頻突變富集測序方法

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Publication number
HK1216184A1
HK1216184A1 HK16104032.4A HK16104032A HK1216184A1 HK 1216184 A1 HK1216184 A1 HK 1216184A1 HK 16104032 A HK16104032 A HK 16104032A HK 1216184 A1 HK1216184 A1 HK 1216184A1
Authority
HK
Hong Kong
Prior art keywords
dna
low
sequencing method
free target
frequency mutation
Prior art date
Application number
HK16104032.4A
Other languages
English (en)
Inventor
吕小星
易鑫
趙美茹
管彥芳
劉濤
楊玲
Original Assignee
Beijing Geneplus Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Geneplus Tech Co Ltd filed Critical Beijing Geneplus Tech Co Ltd
Publication of HK1216184A1 publication Critical patent/HK1216184A1/zh

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HK16104032.4A 2015-08-10 2016-04-08 種血漿中游離的目標 低頻突變富集測序方法 HK1216184A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510487759.1A CN105063208B (zh) 2015-08-10 2015-08-10 一种血浆中游离的目标dna低频突变富集测序方法

Publications (1)

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HK1216184A1 true HK1216184A1 (zh) 2016-10-21

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Country Link
US (1) US11001837B2 (zh)
CN (1) CN105063208B (zh)
HK (1) HK1216184A1 (zh)
WO (1) WO2017024784A1 (zh)

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CN105063208B (zh) 2015-08-10 2018-03-06 北京吉因加科技有限公司 一种血浆中游离的目标dna低频突变富集测序方法
CN105602938A (zh) * 2016-01-22 2016-05-25 北京圣谷同创科技发展有限公司 血浆cfDNA提取方法
CN105950709A (zh) * 2016-03-30 2016-09-21 广州精科生物技术有限公司 试剂盒、建库方法以及检测目标区域变异的方法及系统
CN106047998B (zh) * 2016-05-27 2019-11-12 深圳市海普洛斯生物科技有限公司 一种肺癌基因的检测方法及应用
CN105950739A (zh) * 2016-05-30 2016-09-21 哈尔滨医科大学 用于人乳腺癌循环肿瘤dna检测的探针及其用途
CN107723352A (zh) * 2016-08-12 2018-02-23 嘉兴允英医学检验有限公司 一种循环肿瘤dna肝癌驱动基因高通量检测方法
CN107723351A (zh) * 2016-08-12 2018-02-23 嘉兴允英医学检验有限公司 一种循环肿瘤dna肺癌驱动基因的高通量检测方法
CN107881230A (zh) * 2016-09-30 2018-04-06 复旦大学 一种检测肺癌血浆游离目标dna多位点低频突变的方法和试剂盒
CN106570349B (zh) * 2016-10-28 2019-05-14 深圳华大基因科技服务有限公司 用于目标区域捕获高通量测序的特异性肿瘤探针区域设计方法和装置以及探针
CN106676169B (zh) * 2016-11-15 2021-01-12 上海派森诺医学检验所有限公司 一种用于乳腺癌易感基因brca1和brca2突变检测的杂交捕获试剂盒及其方法
CN108070586A (zh) * 2016-11-18 2018-05-25 杭州拓宏生物科技有限公司 Pcr扩增引物及其应用
CN106755505A (zh) * 2016-12-27 2017-05-31 安诺优达基因科技(北京)有限公司 用于检测血浆ctDNA中基因变异的试剂盒
CN108256294A (zh) * 2016-12-29 2018-07-06 安诺优达基因科技(北京)有限公司 一种用于检测体细胞突变的装置
CN106834275A (zh) * 2017-02-22 2017-06-13 天津诺禾医学检验所有限公司 ctDNA超低频突变检测文库的构建方法、试剂盒及文库检测数据的分析方法
CN108315321A (zh) * 2017-03-31 2018-07-24 索真（北京）医学科技有限公司 尿液ctDNA中K-ras基因突变位点的检测
CN108660135B (zh) * 2017-03-31 2022-09-02 天津华大医学检验所有限公司 一种用于dna建库的试剂盒及其应用
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CN107446996A (zh) * 2017-07-14 2017-12-08 艾吉泰康生物科技(北京)有限公司 一种检测靶序列的超低频突变的接头序列及方法
CN107523563A (zh) * 2017-09-08 2017-12-29 杭州和壹基因科技有限公司 一种用于循环肿瘤dna分析的生物信息处理方法
CN107545152A (zh) * 2017-09-18 2018-01-05 杭州和壹基因科技有限公司 一种基于Illumina数据找变异的方法
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CN108048915A (zh) * 2017-12-01 2018-05-18 北京科迅生物技术有限公司 用于ctDNA文库构建的接头混合物、包括其的试剂盒及应用
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AU2019216810B2 (en) * 2018-02-12 2022-05-12 F. Hoffmann-La Roche Ag Method of predicting response to therapy by assessing tumor genetic heterogeneity
EP3762512A1 (en) * 2018-03-06 2021-01-13 Cancer Research Technology Limited Improvements in variant detection
CN110241209B (zh) * 2018-03-09 2022-11-29 浙江品级基因科技有限公司 一种引物、试剂盒及用途
CN108676845A (zh) * 2018-04-13 2018-10-19 深圳蓝图基因科技有限公司 利用crispr技术剪切非突变靶点以凸显低频突变的方法
CN108531583B (zh) * 2018-05-18 2022-05-17 中国人民解放军陆军军医大学第一附属医院 用于无创检测mitf基因突变的引物组合及检测方法
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