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HK1204608A1 - C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity - Google Patents

C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity Download PDF

Info

Publication number
HK1204608A1
HK1204608A1 HK15105069.8A HK15105069A HK1204608A1 HK 1204608 A1 HK1204608 A1 HK 1204608A1 HK 15105069 A HK15105069 A HK 15105069A HK 1204608 A1 HK1204608 A1 HK 1204608A1
Authority
HK
Hong Kong
Prior art keywords
cycloalkenyl
compounds
inhibitory activity
hiv maturation
hiv
Prior art date
Application number
HK15105069.8A
Other languages
English (en)
Chinese (zh)
Inventor
Swidorski Jacob
A. Meanwell Nicholas
Regueiro-Ren Alicia
Sit Sing-Yuen
Chen Jie
Chen Yan
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48946098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1204608(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK1204608A1 publication Critical patent/HK1204608A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK15105069.8A 2012-02-15 2013-02-13 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity HK1204608A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261599040P 2012-02-15 2012-02-15
US61/599,040 2012-02-15
US13/760,726 2013-02-06
US13/760,726 US8906889B2 (en) 2012-02-15 2013-02-06 C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
PCT/US2013/025897 WO2013123019A1 (en) 2012-02-15 2013-02-13 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Publications (1)

Publication Number Publication Date
HK1204608A1 true HK1204608A1 (en) 2015-11-27

Family

ID=48946098

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105069.8A HK1204608A1 (en) 2012-02-15 2013-02-13 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Country Status (26)

Country Link
US (1) US8906889B2 (xx)
EP (1) EP2814834B1 (xx)
JP (1) JP6155285B2 (xx)
KR (1) KR20140123584A (xx)
CN (2) CN106046106A (xx)
AR (1) AR089996A1 (xx)
AU (1) AU2013221725B2 (xx)
BR (1) BR112014019672A8 (xx)
CA (1) CA2864656A1 (xx)
CL (1) CL2014002141A1 (xx)
CO (1) CO7061077A2 (xx)
EA (1) EA024361B1 (xx)
ES (1) ES2656984T3 (xx)
HK (1) HK1204608A1 (xx)
IL (1) IL234077A (xx)
MX (1) MX2014009235A (xx)
MY (1) MY166793A (xx)
NZ (1) NZ631408A (xx)
PE (1) PE20142315A1 (xx)
PH (1) PH12014501816A1 (xx)
PT (1) PT2814834T (xx)
SG (1) SG11201404748XA (xx)
TW (1) TW201336863A (xx)
UY (1) UY34627A (xx)
WO (1) WO2013123019A1 (xx)
ZA (1) ZA201406724B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
CN105121454A (zh) 2013-02-06 2015-12-02 百时美施贵宝公司 具有hiv成熟抑制活性的c-19经修饰的三萜类化合物
KR102411082B1 (ko) * 2014-04-11 2022-06-17 비브 헬스케어 유케이 (넘버4) 리미티드 할로알킬 치환기를 지니는 비­방향족 고리에 의해 위치 3에서 치환된，ｈｉｖ 성숙화 억제 활성을 갖는 트리테르페노이드
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
BR112017009852A2 (pt) 2014-11-14 2018-01-16 Viiv Healthcare Uk No 5 Ltd composto, composição, e, usos de um composto
CN107250151A (zh) * 2014-11-14 2017-10-13 Viiv保健英国第五有限公司 扩展的桦木酸类似物
WO2016077561A1 (en) 2014-11-14 2016-05-19 Bristol-Myers Squibb Company Oxolupene derivatives
AU2016248068B2 (en) * 2015-04-14 2018-07-26 ViiV Healthcare UK (No.4) Limited Methods of producing an HIV maturation inhibitor
AU2016298667A1 (en) 2015-07-28 2018-02-22 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating HIV infections
EP3328876A1 (en) * 2015-07-28 2018-06-06 Glaxosmithkline Intellectual Property (No. 2) Limited Betuin derivatives for preventing or treating hiv infections
JP2018528231A (ja) 2015-09-24 2018-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有する化合物
CA3011616A1 (en) * 2016-01-20 2017-07-27 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
CN106905264B (zh) * 2017-04-12 2019-06-07 连云港杰瑞药业有限公司 一种合成阿扎拉韦中间体的方法
WO2019055280A1 (en) 2017-09-13 2019-03-21 Emmyon, Inc. DIETHANOLAMINE SALTS AND URSOLIC ACID MORPHOLIN
JP7436385B2 (ja) 2018-04-24 2024-02-21 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Ｈｉｖ成熟阻害活性を有する化合物
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
AU2020222299C1 (en) 2019-02-11 2024-05-16 Hetero Labs Limited Novel triterpene derivatives as HIV inhibitors
WO2020229398A1 (de) 2019-05-14 2020-11-19 Bayer Aktiengesellschaft (1-alkenyl)-substituierte pyrazole und triazole als schädlingsbekämpfungsmittel

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
BRPI0508854A (pt) 2004-03-17 2007-08-28 Panacos Pharmaceuticals Inc sais farmacêuticos de ácido-3-o-(3',3'-dimetilsuccinil) betulìnico
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
WO2008115281A2 (en) 2006-10-16 2008-09-25 Myriad Genetics, Inc. Compounds for treating viral infections
WO2012106190A1 (en) * 2011-01-31 2012-08-09 Bristol-Myers Squibb Company C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
US20090062243A1 (en) 2007-08-03 2009-03-05 Advanced Life Sciences, Inc. Lupane-Type Triterpenoids Modified at 30-Position and Analogues Thereof
MX2010007375A (es) * 2008-01-03 2010-09-30 Virochem Pharma Inc Nuevos derivados de lupano.
AU2009214779A1 (en) * 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17beta lupane derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8759366B2 (en) 2009-12-17 2014-06-24 Merck Sharp & Dohme Corp. Aminopyrimidines as SYK inhibitors
JP5752789B2 (ja) * 2010-06-04 2015-07-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ成熟阻害剤としての修飾ｃ−３ベツリン酸誘導体
EA026140B1 (ru) * 2010-06-04 2017-03-31 Бристол-Майерс Сквибб Компани С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич
PT2588450T (pt) 2010-07-02 2017-08-03 Gilead Sciences Inc Derivados do ácido naft-2-ilacético para tratamento da sida
WO2012106188A1 (en) 2011-01-31 2012-08-09 Bristol-Myers Squibb Company C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors
ES2611727T3 (es) 2011-09-21 2017-05-10 VIIV Healthcare UK (No.5) Limited Derivados de ácido betulínico novedosos con actividad antivírica
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
CN105121454A (zh) * 2013-02-06 2015-12-02 百时美施贵宝公司 具有hiv成熟抑制活性的c-19经修饰的三萜类化合物

Also Published As

Publication number Publication date
EA024361B1 (ru) 2016-09-30
US8906889B2 (en) 2014-12-09
EA201491531A1 (ru) 2014-11-28
ES2656984T3 (es) 2018-03-01
BR112014019672A8 (pt) 2017-07-11
MY166793A (en) 2018-07-23
IL234077A (en) 2016-11-30
PT2814834T (pt) 2017-12-06
PE20142315A1 (es) 2015-01-16
JP6155285B2 (ja) 2017-06-28
AR089996A1 (es) 2014-10-01
CL2014002141A1 (es) 2014-10-03
CA2864656A1 (en) 2013-08-22
CN104220451A (zh) 2014-12-17
JP2015510515A (ja) 2015-04-09
AU2013221725A1 (en) 2014-10-02
CN106046106A (zh) 2016-10-26
SG11201404748XA (en) 2014-09-26
MX2014009235A (es) 2014-11-10
PH12014501816A1 (en) 2014-11-17
IL234077A0 (en) 2014-09-30
CN104220451B (zh) 2016-06-29
WO2013123019A1 (en) 2013-08-22
TW201336863A (zh) 2013-09-16
ZA201406724B (en) 2016-08-31
KR20140123584A (ko) 2014-10-22
UY34627A (es) 2013-09-02
EP2814834B1 (en) 2017-09-13
NZ631408A (en) 2015-06-26
CO7061077A2 (es) 2014-09-19
AU2013221725B2 (en) 2016-10-27
BR112014019672A2 (xx) 2017-06-20
US20130210787A1 (en) 2013-08-15
EP2814834A1 (en) 2014-12-24

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