HK1203072A1 - 用作 抑制劑的乙內酰脲衍生物 - Google Patents
用作 抑制劑的乙內酰脲衍生物Info
- Publication number
- HK1203072A1 HK1203072A1 HK15103579.6A HK15103579A HK1203072A1 HK 1203072 A1 HK1203072 A1 HK 1203072A1 HK 15103579 A HK15103579 A HK 15103579A HK 1203072 A1 HK1203072 A1 HK 1203072A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- derivatives useful
- hydantoin derivatives
- hydantoin
- useful
- Prior art date
Links
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 150000001469 hydantoins Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2011/052414 WO2012076877A1 (en) | 2010-12-06 | 2011-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
| PCT/GB2012/053045 WO2013083994A1 (en) | 2011-12-06 | 2012-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1203072A1 true HK1203072A1 (zh) | 2015-10-16 |
Family
ID=47429936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15103579.6A HK1203072A1 (zh) | 2011-12-06 | 2015-04-13 | 用作 抑制劑的乙內酰脲衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2788339B1 (zh) |
| JP (1) | JP5985651B2 (zh) |
| KR (1) | KR20140098850A (zh) |
| CN (1) | CN103974944B (zh) |
| AU (1) | AU2012349847B2 (zh) |
| CA (1) | CA2856654C (zh) |
| DK (1) | DK2788339T3 (zh) |
| ES (1) | ES2576628T3 (zh) |
| HK (1) | HK1203072A1 (zh) |
| IL (2) | IL232612B (zh) |
| IN (1) | IN2014CN04014A (zh) |
| MX (1) | MX356813B (zh) |
| PL (1) | PL2788339T3 (zh) |
| WO (1) | WO2013083994A1 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
| BR112014028991A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | triazóis como inibidores de kv3 |
| BR112014028718A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
| WO2013182851A1 (en) * | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
| GB201521751D0 (en) * | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
| GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
| WO2018220762A1 (ja) * | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | ピリミジン化合物 |
| JP2022502370A (ja) * | 2018-09-21 | 2022-01-11 | バイオノミクス リミテッド | 置換ピリジニル化合物およびその使用 |
| EP3867247B1 (en) | 2018-10-16 | 2024-07-24 | Autifony Therapeutics Limited | Novel compounds |
| CN115066424B (zh) * | 2020-02-06 | 2024-12-27 | 奥蒂福尼疗法有限公司 | Kv3调节剂 |
| MX2024001899A (es) | 2021-08-10 | 2024-03-01 | Autifony Therapeutics Ltd | Moduladores del canal de potasio. |
| WO2024121552A1 (en) | 2022-12-06 | 2024-06-13 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
| CN117448440B (zh) * | 2023-10-23 | 2024-11-01 | 中国人民解放军空军军医大学 | Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| DK123493D0 (da) * | 1993-11-01 | 1993-11-01 | Lundbeck & Co As H | Compounds |
| CN102256968A (zh) * | 2008-12-22 | 2011-11-23 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
| ES2575215T3 (es) | 2009-12-11 | 2016-06-27 | Autifony Therapeutics Limited | Derivados de imidazolidindiona |
| EP2513092A1 (en) * | 2009-12-14 | 2012-10-24 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| CA2817205C (en) * | 2010-12-06 | 2020-04-07 | Autifony Therapeutics Limited | Hydantoin derivatives useful as kv3 inhibitors |
| CN103596943B (zh) * | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
-
2012
- 2012-12-06 CN CN201280059633.9A patent/CN103974944B/zh active Active
- 2012-12-06 EP EP12806092.8A patent/EP2788339B1/en active Active
- 2012-12-06 DK DK12806092.8T patent/DK2788339T3/en active
- 2012-12-06 JP JP2014545355A patent/JP5985651B2/ja active Active
- 2012-12-06 PL PL12806092.8T patent/PL2788339T3/pl unknown
- 2012-12-06 KR KR1020147018643A patent/KR20140098850A/ko not_active Ceased
- 2012-12-06 ES ES12806092.8T patent/ES2576628T3/es active Active
- 2012-12-06 WO PCT/GB2012/053045 patent/WO2013083994A1/en active Application Filing
- 2012-12-06 AU AU2012349847A patent/AU2012349847B2/en active Active
- 2012-12-06 MX MX2014006753A patent/MX356813B/es active IP Right Grant
- 2012-12-06 IN IN4014CHN2014 patent/IN2014CN04014A/en unknown
- 2012-12-06 CA CA2856654A patent/CA2856654C/en active Active
-
2014
- 2014-05-14 IL IL232612A patent/IL232612B/en active IP Right Grant
-
2015
- 2015-04-13 HK HK15103579.6A patent/HK1203072A1/zh unknown
-
2018
- 2018-04-15 IL IL258704A patent/IL258704B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015502951A (ja) | 2015-01-29 |
| JP5985651B2 (ja) | 2016-09-06 |
| EP2788339A1 (en) | 2014-10-15 |
| IL258704B (en) | 2019-05-30 |
| PL2788339T3 (pl) | 2016-09-30 |
| DK2788339T3 (en) | 2016-05-23 |
| CA2856654A1 (en) | 2013-06-13 |
| CN103974944A (zh) | 2014-08-06 |
| MX2014006753A (es) | 2014-10-15 |
| CA2856654C (en) | 2020-03-31 |
| IL232612A0 (en) | 2014-06-30 |
| AU2012349847A1 (en) | 2014-06-26 |
| AU2012349847B2 (en) | 2017-02-16 |
| IL232612B (en) | 2018-07-31 |
| IL258704A (en) | 2018-06-28 |
| WO2013083994A1 (en) | 2013-06-13 |
| KR20140098850A (ko) | 2014-08-08 |
| IN2014CN04014A (zh) | 2015-07-10 |
| MX356813B (es) | 2018-06-13 |
| CN103974944B (zh) | 2016-11-02 |
| EP2788339B1 (en) | 2016-03-09 |
| ES2576628T3 (es) | 2016-07-08 |
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