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HK1202583A1 - Populations of hematopoietic progenitors and methods of enriching stem cells therefor - Google Patents

Populations of hematopoietic progenitors and methods of enriching stem cells therefor

Info

Publication number
HK1202583A1
HK1202583A1 HK15103113.9A HK15103113A HK1202583A1 HK 1202583 A1 HK1202583 A1 HK 1202583A1 HK 15103113 A HK15103113 A HK 15103113A HK 1202583 A1 HK1202583 A1 HK 1202583A1
Authority
HK
Hong Kong
Prior art keywords
populations
methods
stem cells
hematopoietic progenitors
cells therefor
Prior art date
Application number
HK15103113.9A
Other languages
English (en)
Chinese (zh)
Inventor
Gordon Keller
Juan Carlos Zuniga-Pflucker
Marion J Kennedy
Christopher Michael Sturgeon
Andrea Ditadi
Geneve Sheandra Awong
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of HK1202583A1 publication Critical patent/HK1202583A1/xx

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/35—Polyols, e.g. glycerin, inositol
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    • C12N2500/38—Vitamins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/14—Erythropoietin [EPO]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2311—Interleukin-11 (IL-11)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK15103113.9A 2011-11-21 2015-03-27 Populations of hematopoietic progenitors and methods of enriching stem cells therefor HK1202583A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161562094P 2011-11-21 2011-11-21
PCT/CA2012/001076 WO2013075222A1 (en) 2011-11-21 2012-11-21 Populations of hematopoietic progenitors and methods of enriching stem cells therefor

Publications (1)

Publication Number Publication Date
HK1202583A1 true HK1202583A1 (en) 2015-10-02

Family

ID=48468944

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HK15103113.9A HK1202583A1 (en) 2011-11-21 2015-03-27 Populations of hematopoietic progenitors and methods of enriching stem cells therefor

Country Status (9)

Country Link
US (1) US9834754B2 (ja)
EP (1) EP2782996B1 (ja)
JP (5) JP6344821B2 (ja)
CN (2) CN110241083A (ja)
AU (3) AU2012324017A1 (ja)
CA (1) CA2856322C (ja)
HK (1) HK1202583A1 (ja)
SG (2) SG10201709546YA (ja)
WO (1) WO2013075222A1 (ja)

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US12146161B2 (en) 2015-02-11 2024-11-19 The Hosptial For Sick Children Mammalian alveolar macrophages derived from pluripotent cells
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CN108350429B (zh) 2015-10-20 2022-02-25 富士胶片细胞动力公司 用于将多能干细胞定向分化为免疫细胞的方法
CN108368520B (zh) 2015-11-04 2023-01-17 菲特治疗公司 多能细胞的基因组工程改造
WO2017078807A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
EP3510145A4 (en) 2016-09-06 2020-03-25 The Children's Medical Center Corporation Immune cells derived from induced pluripotent stem cell
US10961505B2 (en) 2016-10-05 2021-03-30 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
JP7131775B2 (ja) 2017-02-06 2022-09-06 国立研究開発法人国立がん研究センター 新規ｔ細胞受容体
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WO2018199186A1 (ja) * 2017-04-26 2018-11-01 国立大学法人京都大学 造血前駆細胞マーカー
CA3091158A1 (en) * 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
US20210130777A1 (en) 2018-07-13 2021-05-06 Kyoto University Method for producing gamma delta t cells
TW202434719A (zh) 2018-08-10 2024-09-01 國立大學法人京都大學 Ｃｄ３陽性細胞的製造方法
IL282563B1 (en) * 2018-10-24 2025-01-01 Hebecell Corp Methods and systems for producing lineage cells involved in the formation of blood cells
SG11202106642YA (en) * 2018-12-20 2021-07-29 Sumitomo Chemical Co Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method
US20220089672A1 (en) 2018-12-27 2022-03-24 Kyoto University T-cell receptor modified object
WO2020154412A1 (en) * 2019-01-22 2020-07-30 Washington University Compositions and methods for generating hematopoietic stem cells (hscs)
CN113646424A (zh) * 2019-03-29 2021-11-12 富士胶片株式会社 具有分化成特定细胞的能力的多能干细胞的制造方法及其应用
JP7533896B2 (ja) 2019-03-29 2024-08-14 公立大学法人横浜市立大学 スクリーニング方法および毒性評価法
RU2722669C1 (ru) * 2019-07-01 2020-06-02 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) Способ получения ассоциатов гемопоэтических и стромальных клеток-предшественников, способных подавлять активацию и пролиферацию аллогенных лимфоцитов
TW202134429A (zh) 2019-11-25 2021-09-16 國立大學法人京都大學 Ｔ細胞主細胞庫
MX2022008648A (es) 2020-01-23 2022-12-15 The Children´S Medical Center Corp Diferenciacion de celulas t sin estroma a partir de celulas madre pluripotentes humanas.
CN113552363B (zh) * 2020-04-03 2024-03-08 中国科学院广州生物医药与健康研究院 Cd44作为造血干/祖细胞的标志物及其应用
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
WO2023210661A1 (ja) * 2022-04-25 2023-11-02 国立大学法人金沢大学 ＣＡＲ－Ｔ細胞活性化、造血幹細胞増殖、ｉＰＳ細胞分化を制御する組成物およびその用途
WO2023247722A1 (en) * 2022-06-22 2023-12-28 Fondazione Telethon Ets Method for isolating hemogenic endothelial cells
WO2024024551A1 (ja) 2022-07-26 2024-02-01 国立大学法人京都大学 シェディング構造を有する人工受容体

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JP6344821B2 (ja) 2018-06-20
SG11201402502RA (en) 2015-01-29
US20140322808A1 (en) 2014-10-30
CN104053769A (zh) 2014-09-17
CA2856322A1 (en) 2013-05-30
AU2012324017A1 (en) 2013-06-06
JP2019136045A (ja) 2019-08-22
JP2014533494A (ja) 2014-12-15
WO2013075222A1 (en) 2013-05-30
CA2856322C (en) 2021-10-12
SG10201709546YA (en) 2017-12-28
EP2782996A1 (en) 2014-10-01
JP2017104129A (ja) 2017-06-15
JP2023029655A (ja) 2023-03-03
EP2782996B1 (en) 2019-03-27
CN110241083A (zh) 2019-09-17
AU2018202355B2 (en) 2019-07-25
US9834754B2 (en) 2017-12-05
AU2016222344A1 (en) 2016-09-22
EP2782996A4 (en) 2015-04-08
JP2021100436A (ja) 2021-07-08
AU2018202355A1 (en) 2018-04-26

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