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HK1190073A1 - 治療椎間盤突出的軟骨素酶 - Google Patents

治療椎間盤突出的軟骨素酶

Info

Publication number
HK1190073A1
HK1190073A1 HK14103160.2A HK14103160A HK1190073A1 HK 1190073 A1 HK1190073 A1 HK 1190073A1 HK 14103160 A HK14103160 A HK 14103160A HK 1190073 A1 HK1190073 A1 HK 1190073A1
Authority
HK
Hong Kong
Prior art keywords
abc
disc herniation
chondroitinase
treating disc
treating
Prior art date
Application number
HK14103160.2A
Other languages
English (en)
Inventor
Taiichi Sirogane
Takao Murayama
Masafumi Yaguchi
Original Assignee
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd
Publication of HK1190073A1 publication Critical patent/HK1190073A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02004—Chondroitin ABC lyase (4.2.2.4), i.e. chondroitinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/0202—Chondroitin-sulfate-ABC endolyase (4.2.2.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02021—Chondroitin-sulfate-ABC exolyase (4.2.2.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
HK14103160.2A 2010-12-13 2014-04-02 治療椎間盤突出的軟骨素酶 HK1190073A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010277490 2010-12-13
PCT/JP2011/006938 WO2012081227A1 (ja) 2010-12-13 2011-12-13 椎間板ヘルニア治療剤

Publications (1)

Publication Number Publication Date
HK1190073A1 true HK1190073A1 (zh) 2014-06-27

Family

ID=46244346

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14103160.2A HK1190073A1 (zh) 2010-12-13 2014-04-02 治療椎間盤突出的軟骨素酶

Country Status (16)

Country Link
US (6) US20130266555A1 (zh)
EP (1) EP2653168B1 (zh)
JP (1) JP5465791B2 (zh)
KR (2) KR20170004032A (zh)
CN (5) CN106975077A (zh)
BR (1) BR112013014584B1 (zh)
CA (1) CA2821244C (zh)
DK (1) DK2653168T3 (zh)
ES (1) ES2536982T3 (zh)
HK (1) HK1190073A1 (zh)
PL (1) PL2653168T3 (zh)
PT (1) PT2653168E (zh)
RU (2) RU2690185C2 (zh)
TW (1) TWI488641B (zh)
WO (1) WO2012081227A1 (zh)
ZA (1) ZA201304924B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170004032A (ko) 2010-12-13 2017-01-10 세이가가쿠 고교 가부시키가이샤 추간판 헤르니아 치료제
EP3439691A4 (en) * 2016-04-04 2020-05-13 GU Ventures AB METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIA
US20190284263A1 (en) * 2016-04-29 2019-09-19 Inovio Pharmaceuticals, Inc. In vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
US20230092556A1 (en) * 2016-04-29 2023-03-23 Inovio Pharmaceuticals, Inc. In vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
US9796970B1 (en) 2017-04-24 2017-10-24 Advantek Serum Laboratories Ltd. Production of high purity chondroitinase ABC
KR20200126993A (ko) 2018-02-28 2020-11-09 세이가가쿠 고교 가부시키가이샤 의약 조성물, 포장체 및 그 제조 방법
CA3092218A1 (en) 2018-02-28 2019-09-06 Seikagaku Corporation Package and method for producing the same
KR102270354B1 (ko) * 2018-10-08 2021-06-30 한국과학기술연구원 단결정 이종 2차원 물질의 애피택셜 성장 방법 및 적층 구조체
JP2022151423A (ja) * 2021-03-25 2022-10-07 均 石井 椎間板ヘルニア治療薬。

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696816A (en) * 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
JP3980657B2 (ja) 1992-06-26 2007-09-26 生化学工業株式会社 コンドロイチナーゼａｂｃ、その製造法及び医薬組成物
US5496718A (en) * 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
EP0875253B1 (en) * 1997-05-02 2005-04-06 Seikagaku Corporation Chondroitinase compositions
EP0900569B1 (en) * 1997-08-22 2002-10-02 Seikagaku Corporation Therapeutic agent for herniated intervertebral disc
JPH11193245A (ja) * 1997-12-26 1999-07-21 Seikagaku Kogyo Co Ltd コンドロイチナーゼａｂｃ組成物
WO2000020021A1 (en) * 1998-10-06 2000-04-13 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
JP3865364B2 (ja) * 2000-10-10 2007-01-10 生化学工業株式会社 コンドロイチナーゼ画分
JP4439396B2 (ja) * 2002-06-24 2010-03-24 田辺三菱製薬株式会社 神経系細胞の製造方法
DE10308885A1 (de) * 2003-02-28 2004-09-23 Syha, Klaus, Dr. Verwendung glycosidasehaltiger Lösungen zur Behandlung von neuronalen Zellen
TW200817015A (en) * 2006-10-06 2008-04-16 Hen-Rich Cheng A method for promoting axonal re-growth and behavior recovery in spinal cord injury
US9381216B2 (en) * 2007-08-06 2016-07-05 Mesoblast, Inc. Methods of generating, repairing and/or maintaining connective tissue in vivo
CN101406695A (zh) * 2007-10-08 2009-04-15 郑宏志 促进脊髓损伤中轴突再生和行为功能恢复的药物组合物
EP2286828B1 (en) * 2008-04-14 2016-05-18 National University Corporation Nagoya University Improving agent for neuropathic pain
KR20170004032A (ko) 2010-12-13 2017-01-10 세이가가쿠 고교 가부시키가이샤 추간판 헤르니아 치료제

Also Published As

Publication number Publication date
PL2653168T3 (pl) 2015-07-31
CN103260636A (zh) 2013-08-21
CN111420040A (zh) 2020-07-17
US20220160845A1 (en) 2022-05-26
US11266725B2 (en) 2022-03-08
RU2690185C2 (ru) 2019-05-31
US20190224289A1 (en) 2019-07-25
JP5465791B2 (ja) 2014-04-09
KR20170004032A (ko) 2017-01-10
WO2012081227A1 (ja) 2012-06-21
KR101692517B1 (ko) 2017-01-03
RU2015135843A (ru) 2018-12-25
RU2015135843A3 (zh) 2019-03-26
RU2013132566A (ru) 2015-01-20
CA2821244C (en) 2016-08-09
ES2536982T3 (es) 2015-06-01
TW201306860A (zh) 2013-02-16
US10286046B2 (en) 2019-05-14
EP2653168A4 (en) 2014-06-25
EP2653168B1 (en) 2015-03-04
RU2019116210A (ru) 2020-11-27
BR112013014584B1 (pt) 2020-12-01
US20150071896A1 (en) 2015-03-12
KR20130139284A (ko) 2013-12-20
CA2821244A1 (en) 2012-06-21
JPWO2012081227A1 (ja) 2014-05-22
CN110101852A (zh) 2019-08-09
DK2653168T3 (da) 2015-04-20
US20170000863A1 (en) 2017-01-05
EP2653168A1 (en) 2013-10-23
US9463225B2 (en) 2016-10-11
PT2653168E (pt) 2015-04-01
BR112013014584A2 (pt) 2016-09-20
US20130266555A1 (en) 2013-10-10
RU2564001C2 (ru) 2015-09-27
US11944670B2 (en) 2024-04-02
CN106975077A (zh) 2017-07-25
TWI488641B (zh) 2015-06-21
US20250018018A1 (en) 2025-01-16
ZA201304924B (en) 2014-09-25
CN111265472A (zh) 2020-06-12

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