HK1129121A1 - Glp-1 (glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance - Google Patents

Glp-1 (glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Info

Publication number: HK1129121A1
Authority: HK; Hong Kong
Prior art keywords: glp; glucagon; peptide; fusion polypeptides; peptidase resistance
Prior art date: 2005-09-22

Application number

HK09109186.6A

Other languages

English (en)

Inventor

Peter Geigle

Eric Thoenes

Christine Wallrapp

Original Assignee

Biocompatibles Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-22

Filing date

2009-10-05

Publication date

2009-11-20

2009-10-05 Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd

2009-11-20 Publication of HK1129121A1 publication Critical patent/HK1129121A1/xx

Links

101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
102400000322 Glucagon-like peptide 1 Human genes 0.000 title 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title 1
101800000224 Glucagon-like peptide 1 Proteins 0.000 title 1
102000035195 Peptidases Human genes 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
230000004927 fusion Effects 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
235000019833 protease Nutrition 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- G—PHYSICS
- G07—CHECKING-DEVICES
- G07F—COIN-FREED OR LIKE APPARATUS
- G07F11/00—Coin-freed apparatus for dispensing, or the like, discrete articles
- G07F11/02—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines
- G07F11/04—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines in which magazines the articles are stored one vertically above the other
- G07F11/16—Delivery means
- G07F11/165—Delivery means using xyz-picker or multi-dimensional article picking arrangements

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

HK09109186.6A 2005-09-22 2009-10-05 Glp-1 (glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance HK1129121A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05020718A EP1767545B1 (de)	2005-09-22	2005-09-22	Fusionspolypeptide vom glp-1 (glucagon-like peptide-1) mit erhöhten peptidaseresistenz

Publications (1)

Publication Number	Publication Date
HK1129121A1 true HK1129121A1 (en)	2009-11-20

Family

ID=35700191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK09109186.6A HK1129121A1 (en)	2005-09-22	2009-10-05	Glp-1 (glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Country Status (24)

Country	Link
US (2)	US8431533B2 (de)
EP (5)	EP2045265B1 (de)
JP (2)	JP5222729B2 (de)
KR (1)	KR20080064840A (de)
CN (1)	CN101273058A (de)
AT (1)	ATE448247T1 (de)
AU (1)	AU2006299134B2 (de)
BR (1)	BRPI0616107A2 (de)
CA (1)	CA2619053A1 (de)
CY (1)	CY1109778T1 (de)
DE (1)	DE602005017628D1 (de)
DK (1)	DK1767545T3 (de)
EA (1)	EA013796B1 (de)
ES (3)	ES2336575T3 (de)
HK (1)	HK1129121A1 (de)
HR (1)	HRP20100062T1 (de)
IL (1)	IL188904A0 (de)
PL (1)	PL1767545T3 (de)
PT (1)	PT1767545E (de)
RS (1)	RS51319B (de)
SG (1)	SG165414A1 (de)
SI (1)	SI1767545T1 (de)
WO (1)	WO2007039140A1 (de)
ZA (1)	ZA200803488B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1767545T3 (da)	2005-09-22	2010-03-15	Biocompatibles Uk Ltd	GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens
EP1948676A4 (de) *	2005-10-27	2011-05-25	Peptron Co Ltd	Biologisch wirksames substanz-protein-konjugat und stabilisierung einer biologisch aktiven substanz damit
US20130172274A1 (en)	2005-12-20	2013-07-04	Duke University	Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en)	2005-12-20	2014-09-23	Duke University	Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
DE602006009631D1 (de)	2006-05-10	2009-11-19	Biocompatibles Uk Ltd	GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung
EP1972349A1 (de) *	2007-03-21	2008-09-24	Biocompatibles UK Limited	Mit Polymer(en) konjugierte GLP-1-Fusionspeptide, ihre Herstellung und Verwendung
EP1975176A1 (de) *	2007-03-27	2008-10-01	Biocompatibles UK Limited	Neue GLP-1-Fusionspeptide, ihre Herstellung und Verwendung
CN105727261A (zh)	2008-06-27	2016-07-06	杜克大学	包含弹性蛋白样肽的治疗剂
EP2163243A1 (de) *	2008-09-12	2010-03-17	Biocompatibles UK Limited	Behandlung akuter Herzinfarkte mithilfe eingekapselter Zellen, welche GLP-1-Peptide oder deren Analoga kodieren und absondern
CN101993485B (zh)	2009-08-20	2013-04-17	重庆富进生物医药有限公司	促胰岛素分泌肽类似物同源二聚体及其用途
RU2584572C2 (ru) *	2010-02-11	2016-05-20	Ф.Хоффманн-Ля Рош Аг	Способ получения полипептида, конъюгированного с поли(этиленгликолевым) фрагментом, нуклеиновая кислота и слитый полипептид, предназначенные для применения в способе
EP2623512A4 (de) *	2010-10-01	2014-03-26	Mmt Co Ltd	Zur bindung von immunglobulin fähiges peptid
CN102766204B (zh) *	2011-05-05	2014-10-15	天津药物研究院	胰高血糖素样肽-1突变体多肽及其制备方法和其应用
CN102363633B (zh) *	2011-11-16	2013-11-20	天津拓飞生物科技有限公司	胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用
MX360816B (es)	2012-11-20	2018-11-15	Mederis Diabetes Llc	Productos farmacéuticos peptídicos mejorados para la resistencia a la insulina.
CN104371019B (zh)	2013-08-13	2019-09-10	鸿运华宁（杭州）生物医药有限公司	一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质
CN104707131A (zh) *	2013-12-13	2015-06-17	上海建华精细生物制品有限公司	一种药物组合物及其制备方法和用途
PT3155017T (pt)	2014-05-28	2024-05-14	Mederis Diabetes Llc	Farmacêuticos peptídicos melhorados para resistência à insulina
PT3257524T (pt)	2015-02-11	2020-11-27	Gmax Biopharm Llc	Preparação de solução estabilizada de proteína de fusão de anticorpo glp-1r farmacêutica
ES2968038T3 (es)	2015-12-23	2024-05-06	Univ Johns Hopkins	Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas
CN107818433B (zh) *	2016-09-14	2022-07-05	菜鸟智能物流控股有限公司	取件方法、物流信息处理方法及装置、系统
WO2018104558A1 (en) *	2016-12-09	2018-06-14	Zealand Pharma A/S	Acylated glp-1/glp-2 dual agonists
WO2018104559A1 (en) *	2016-12-09	2018-06-14	Zealand Pharma A/S	Glp-1/glp-2 dual agonists
EP3551651B1 (de)	2016-12-09	2024-03-06	Zealand Pharma A/S	Acylierte glp-1/glp-2 duale agoniste
CN108341880B (zh) *	2017-01-23	2023-07-04	天津药物研究院有限公司	含有胰高血糖素样肽-1和胰高血糖素的片段类似物的嵌合多肽及其用途
KR101827245B1 (ko) *	2017-12-26	2018-02-08	(주)제이유타이드	알라린을 주성분으로 하는 요독증 치료제
HUE069178T2 (hu)	2018-01-03	2025-02-28	Mederis Diabetes Llc	Javított peptidgyógyszerek NASH és egyéb rendellenességek kezelésére
KR101903564B1 (ko) *	2018-01-31	2018-11-13	한국지질자원연구원	제지공정에서 발생되는 부산물의 재활용 방법
RS63523B1 (sr)	2018-04-05	2022-09-30	Sun Pharmaceutical Ind Ltd	Novi glp-1 analozi
EP3901173A4 (de)	2018-12-21	2022-11-23	Jiangsu Hengrui Medicine Co., Ltd.	Bispezifisches protein
US20240368239A1 (en) *	2020-03-12	2024-11-07	Sl Metagen	Novel bispecific protein and use thereof
KR102349717B1 (ko) *	2020-03-12	2022-01-11	주식회사 에스엘메타젠	신규 대사증후군 및 그와 관련된 질환 치료용 약학 조성물
WO2022015039A1 (ko) *	2020-07-14	2022-01-20	(주)지아이이노베이션	글루카곤-유사 펩타이드-1 및 글루카곤-유사 펩타이드-2를 포함하는 융합 단백질 및 이의 용도
GB2617717A (en) *	2020-11-27	2023-10-18	D&D Pharmatech Inc	Biologically active material conjugate having biotin moiety, fatty acid moiety, or combination thereof coupled thereto
IL303023A (en) *	2020-11-27	2023-07-01	D& D Pharmatech Inc	Oral formulation of biologically active material conjugate having biotin moiety, fatty acid moiety, or combination thereof coupled thereto
CN112661862B (zh) *	2020-12-25	2023-03-31	深圳大学	一种融合蛋白及其制备方法和应用
CN113846124A (zh) *	2021-09-26	2021-12-28	康霖生物科技（杭州）有限公司	一种用于糖代谢相关疾病基因治疗的核酸构建体
US12171806B2 (en)	2021-09-28	2024-12-24	Spitfire Pharma Llc	Therapeutic regimens and methods for lowering blood glucose and/or body weight using GLP-1R and GCGR balanced agonists
CN114874314B (zh) *	2021-12-28	2022-11-11	北京惠之衡生物科技有限公司	一种高表达glp-1类似物的重组工程菌及其构建方法
CN115920004A (zh) *	2022-11-11	2023-04-07	深圳市图微安创科技开发有限公司	药物组合物及其制备方法
WO2024144431A1 (ru) *	2022-12-29	2024-07-04	Авва Фармасьютикалс Лтд	Новый штамм-продуцент escherichia coli, продуцирующий гибридный белок cbd-hs-es-glp1, и способ получения полипептида glp-1
WO2025005743A1 (ko) *	2023-06-30	2025-01-02	주식회사 휴온스랩	Glp 유사체를 유효성분으로 포함하는 비만 예방 또는 치료용 약학적 조성물

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US586128A (en) *		1897-07-13		Toilet-paper holder
US4352883A (en) *	1979-03-28	1982-10-05	Damon Corporation	Encapsulation of biological material
ATE6548T1 (de)	1979-10-16	1984-03-15	Winfried Dr. Med. Stoecker	Vorrichtung zur durchfuehrung von mikroanalysen.
US4596792A (en)	1981-09-04	1986-06-24	The Regents Of The University Of California	Safe vaccine for hepatitis containing polymerized serum albumin
JPS5938877A (ja)	1982-08-30	1984-03-02	Musashi Eng Kk	紙葉判別方法
US4737462A (en)	1982-10-19	1988-04-12	Cetus Corporation	Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4588585A (en)	1982-10-19	1986-05-13	Cetus Corporation	Human recombinant cysteine depleted interferon-β muteins
US4518584A (en)	1983-04-15	1985-05-21	Cetus Corporation	Human recombinant interleukin-2 muteins
DD224119A1 (de)	1983-11-07	1985-06-26	Univ Schiller Jena	Temperierbarer probentraeger
US4599230A (en)	1984-03-09	1986-07-08	Scripps Clinic And Research Foundation	Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en)	1984-03-09	1986-07-08	Scripps Clinic And Research Foundation	Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en)	1984-11-09	1986-08-26	Pitman-Moore, Inc.	LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4959314A (en)	1984-11-09	1990-09-25	Cetus Corporation	Cysteine-depleted muteins of biologically active proteins
US5116943A (en)	1985-01-18	1992-05-26	Cetus Corporation	Oxidation-resistant muteins of Il-2 and other protein
US4601903A (en)	1985-05-01	1986-07-22	The United States Of America As Represented By The Department Of Health And Human Services	Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US5144139A (en)	1985-08-05	1992-09-01	Biotrack, Inc.	Capillary flow device
US4687529A (en)	1985-08-30	1987-08-18	Miles Laboratories, Inc.	Method of making a reagent test device containing hydrophobic barriers
CA1292176C (en)	1985-09-18	1991-11-19	Joel M. Blatt	Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US5017691A (en)	1986-07-03	1991-05-21	Schering Corporation	Mammalian interleukin-4
US6849708B1 (en)	1986-05-05	2005-02-01	The General Hospital Corporation	Insulinotropic hormone and uses thereof
US4965195A (en)	1987-10-26	1990-10-23	Immunex Corp.	Interleukin-7
US4904584A (en)	1987-12-23	1990-02-27	Genetics Institute, Inc.	Site-specific homogeneous modification of polypeptides
ES2113879T3 (es)	1990-01-24	1998-05-16	Douglas I Buckley	Analogos de glp-1 utiles para el tratamiento de diabetes.
ATE138102T1 (de)	1991-02-19	1996-06-15	Takeda Chemical Industries Ltd	Verfahren zur herstellung von cysteinfreien peptiden
CA2062338A1 (en)	1991-03-15	1992-09-16	Zia Yassinzadeh	Electronic control cartridge and method of simulating light transmission patterns
GB9311147D0 (en)	1993-05-28	1993-07-14	Long Ashton Research Station	Regulation of plant growth
US5705483A (en)	1993-12-09	1998-01-06	Eli Lilly And Company	Glucagon-like insulinotropic peptides, compositions and methods
US5512549A (en)	1994-10-18	1996-04-30	Eli Lilly And Company	Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
BE1008987A3 (fr)	1995-01-06	1996-10-01	Robyn Pierre	Blocs refractaires a canalisations pour sols de fours verriers et installation dans les sols de circuits de refroidissement ou de chauffage, permettant d'ameliorer le controle thermique des sols et la qualite du verre.
JP3643863B2 (ja)	1995-08-09	2005-04-27	アークレイ株式会社	液体保持具とその製造方法
DK0891378T3 (da)	1996-03-01	2003-01-06	Novo Nordisk As	Anvendelse af farmaceutisk formulering omfattende et appetitundertrykkende peptid
US6165739A (en)	1996-03-13	2000-12-26	Compucyte Corporation	Multiple simultaneous testing media
EP2016950B1 (de) *	1996-08-08	2011-01-05	Amylin Pharmaceuticals, Inc.	Pharmazeutische Zusammensetzung mit einem Exendin-4-Peptid
DE122009000079I2 (de) *	1996-08-30	2011-06-16	Novo Nordisk As Novo Alle	Glp-1 derivate
ES2290799T3 (es)	1996-11-12	2008-02-16	Novo Nordisk A/S	Uso de peptidos glp-1.
EP1045898A2 (de)	1998-01-12	2000-10-25	Betagene, Inc.	Zusammensetzungen und verfahren für die regulierung der expression aus neuroendocrinezellinien
WO1999044638A1 (en)	1998-03-06	1999-09-10	Spectrx, Inc.	Photothermal structure for biomedical applications, and method therefor
EP1950224A3 (de) *	1998-03-09	2008-12-17	Zealand Pharma A/S	Pharmakologisch aktive Peptidkonjugate mit verringerter enzymatischer Hydrolysetendenz
WO1999053064A2 (en)	1998-04-13	1999-10-21	Modex Therapeutiques, S.A.	Methods of delivering glp-1
US7259136B2 (en)	1999-04-30	2007-08-21	Amylin Pharmaceuticals, Inc.	Compositions and methods for treating peripheral vascular disease
US6267954B1 (en)	1999-11-24	2001-07-31	Universite De Paris V Rene-Descartes	Intraocular transplantation of encapsulated cells
US6706159B2 (en)	2000-03-02	2004-03-16	Diabetes Diagnostics	Combined lancet and electrochemical analyte-testing apparatus
EP1263458B1 (de)	2000-03-08	2005-11-16	Novo Nordisk A/S	Senkung des serum cholesterols
DE10039643A1 (de) *	2000-08-14	2002-02-28	Max Planck Gesellschaft	Funktionalisierte Perylentetracarbonsäurediimide
ES2311560T3 (es) *	2000-12-07	2009-02-16	Eli Lilly And Company	Proteinas de fusion glp-1.
EP1358123A2 (de)	2001-02-09	2003-11-05	Wisconsin Alumni Research Foundation	Verfahren und struktur zur führung von mikrofluidischem durchfluss
AU2002240463A1 (en)	2001-02-22	2002-09-12	Novartis Ag	Use of endostatin in the treatment of ocular neovascularization
US20030034147A1 (en)	2001-05-31	2003-02-20	Houck Glenn M.	Apparatus which eliminates the need for idling by trucks
ES2298378T3 (es)	2001-06-28	2008-05-16	Novo Nordisk A/S	Formulacion estable de glp-1 modificado.
CN1363654A (zh)	2001-07-19	2002-08-14	上海华谊生物技术有限公司	生产促胰岛素分泌肽glp－1(7－36)的基因工程菌以及生产glp－1(7－36)的方法
EP1430115A1 (de)	2001-07-27	2004-06-23	Arhus Amt	Immortalisierte stammzellen
US7576050B2 (en)	2001-07-31	2009-08-18	The United States Of America As Represented By The Department Of Health And Human Services	GLP-1 exendin-4 peptide analogs and uses thereof
US20040143104A1 (en)	2001-08-08	2004-07-22	Wadsworth Samuel C.	Methods of treating diabetes and other blood sugar disorders
JP2005508895A (ja)	2001-08-28	2005-04-07	イーライ・リリー・アンド・カンパニー	Ｇｌｐ−１および基礎インスリンの予備混合物
US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US7166208B2 (en)	2004-03-03	2007-01-23	Stephen Eliot Zweig	Apoenzyme reactivation electrochemical detection method and assay
EP1790353A1 (de)	2001-12-29	2007-05-30	Novo Nordisk A/S	Kombinierte Verwendung einer GLP-1-Verbidnung und eines Modulators für Spätfolgen bei Diabetes
BR0306706A (pt) *	2002-01-08	2007-03-27	Lilly Co Eli	peptìdeo glp-1 estendido, métodos de estimulação do receptor de glp-1 em um indivìduo necessitando de normalização de glicose sanguìnea, de tratamento de um indivìduo profilaticamente para diabetes independente de insulina, de redução ou de manutenção do peso corporal, de tratamento da obesidade, e de tratamento de doenças, em um indivìduo necessitando do mesmo, uso de um composto de glp-1, processo de preparação de uma formulação farmacêutica, e, formulação farmacêutica
GB2388898B (en)	2002-04-02	2005-10-05	Inverness Medical Ltd	Integrated sample testing meter
US20030191056A1 (en) *	2002-04-04	2003-10-09	Kenneth Walker	Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
US20030143113A2 (en)	2002-05-09	2003-07-31	Lifescan, Inc.	Physiological sample collection devices and methods of using the same
CA2497794A1 (en)	2002-09-06	2004-03-18	Bayer Pharmaceuticals Corporation	Modified glp-1 receptor agonists and their pharmacological methods of use
WO2004078195A1 (ja) *	2003-03-07	2004-09-16	Ajinomoto Co., Inc.	腸管細胞のインスリン産生細胞への変換誘導剤、及び糖尿病治療剤
US6969166B2 (en)	2003-05-29	2005-11-29	3M Innovative Properties Company	Method for modifying the surface of a substrate
US7057116B2 (en)	2003-06-02	2006-06-06	Intel Corporation	Selective reference plane bridge(s) on folded package
PT1641823E (pt) *	2003-06-12	2011-11-08	Lilly Co Eli	Proteínas de fusão de análogos de glp-1
EP1498143A1 (de)	2003-07-18	2005-01-19	Aventis Pharma S.A.	Selbstemulgierende und selbstmicroemulgierende Formulierungen zur oralen Verabreichung von Taxoiden
WO2005014049A2 (en)	2003-08-08	2005-02-17	Novo Nordisk A/S	Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides
WO2005034988A1 (en)	2003-10-10	2005-04-21	Novo Nordisk A/S	Long-acting molecules in sustained release formulations
WO2005058958A2 (en)	2003-12-18	2005-06-30	Novo Nordisk A/S	Novel glp-1 analogues linked to albumin-like agents
WO2005072216A2 (en)	2004-01-20	2005-08-11	The Curators Of The University Of Missouri	Supported molecular biofluid viscosity sensors for in vitro and in vivo use
EP2422806A3 (de)	2004-02-11	2012-06-13	Amylin Pharmaceuticals Inc.	Hybridpolypeptide mit auswahlbaren Eigenschaften
BRPI0418539A (pt)	2004-03-05	2007-05-22	Egomedical Swiss Ag	sistema de teste de analito para a determinação da concentração de um analito em um fluido fisiológico
KR20070004078A (ko)	2004-03-31	2007-01-05	센토코 인코포레이티드	인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도
US20080300173A1 (en) *	2004-07-13	2008-12-04	Defrees Shawn	Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1776464B1 (de)	2004-08-13	2009-10-07	Egomedical Technologies AG	Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen oder wässrigen flüssigkeit
US7442682B2 (en)	2004-10-19	2008-10-28	Nitto Denko Corporation	Transepithelial delivery of peptides with incretin hormone activities
JP2009510999A (ja)	2005-07-29	2009-03-19	エーエムプロテインコーポレイション	キメラ治療剤
DK1767545T3 (da)	2005-09-22	2010-03-15	Biocompatibles Uk Ltd	GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens
DE602006009631D1 (de)	2006-05-10	2009-11-19	Biocompatibles Uk Ltd	GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung
EP1972349A1 (de)	2007-03-21	2008-09-24	Biocompatibles UK Limited	Mit Polymer(en) konjugierte GLP-1-Fusionspeptide, ihre Herstellung und Verwendung
EP1975176A1 (de)	2007-03-27	2008-10-01	Biocompatibles UK Limited	Neue GLP-1-Fusionspeptide, ihre Herstellung und Verwendung
EP2163243A1 (de)	2008-09-12	2010-03-17	Biocompatibles UK Limited	Behandlung akuter Herzinfarkte mithilfe eingekapselter Zellen, welche GLP-1-Peptide oder deren Analoga kodieren und absondern

2005
- 2005-09-22 DK DK05020718.2T patent/DK1767545T3/da active
- 2005-09-22 RS RSP-2010/0039A patent/RS51319B/sr unknown
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- 2005-09-22 EP EP08021837A patent/EP2045265B1/de active Active
- 2005-09-22 ES ES08021837T patent/ES2397289T3/es active Active
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- 2005-09-22 AT AT05020718T patent/ATE448247T1/de active
- 2005-09-22 EP EP05020718A patent/EP1767545B1/de active Active
2006
- 2006-09-22 EP EP10009718A patent/EP2261245A1/de not_active Withdrawn
- 2006-09-22 EP EP06792228A patent/EP1926748B1/de not_active Not-in-force
- 2006-09-22 WO PCT/EP2006/009226 patent/WO2007039140A1/en active Application Filing
- 2006-09-22 EA EA200800699A patent/EA013796B1/ru not_active IP Right Cessation
- 2006-09-22 KR KR1020087009543A patent/KR20080064840A/ko not_active Ceased
- 2006-09-22 EP EP09014513A patent/EP2174952A3/de not_active Withdrawn
- 2006-09-22 CA CA002619053A patent/CA2619053A1/en not_active Abandoned
- 2006-09-22 ZA ZA200803488A patent/ZA200803488B/xx unknown
- 2006-09-22 ES ES06792228T patent/ES2394218T3/es active Active
- 2006-09-22 US US11/991,562 patent/US8431533B2/en not_active Expired - Fee Related
- 2006-09-22 CN CNA2006800350367A patent/CN101273058A/zh active Pending
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2008
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2009
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2010
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Also Published As

Publication number	Publication date
JP2013099352A (ja)	2013-05-23
PL1767545T3 (pl)	2010-04-30
US8853159B2 (en)	2014-10-07
HRP20100062T1 (hr)	2010-03-31
EP2045265B1 (de)	2012-11-21
JP2009508505A (ja)	2009-03-05
EP1926748A1 (de)	2008-06-04
RS51319B (sr)	2010-12-31
ES2394218T3 (es)	2013-01-23
IL188904A0 (en)	2008-04-13
DK1767545T3 (da)	2010-03-15
EA013796B1 (ru)	2010-06-30
SG165414A1 (en)	2010-10-28
US20110130329A1 (en)	2011-06-02
JP5222729B2 (ja)	2013-06-26
ATE448247T1 (de)	2009-11-15
CY1109778T1 (el)	2014-09-10
EP2174952A3 (de)	2010-11-17
ES2397289T3 (es)	2013-03-06
CN101273058A (zh)	2008-09-24
CA2619053A1 (en)	2007-04-12
EP1926748B1 (de)	2012-08-29
EP1767545A1 (de)	2007-03-28
US8431533B2 (en)	2013-04-30
BRPI0616107A2 (pt)	2011-06-07
EP2045265A1 (de)	2009-04-08
KR20080064840A (ko)	2008-07-09
EP1767545B1 (de)	2009-11-11
EA200800699A1 (ru)	2008-10-30
ZA200803488B (en)	2009-10-28
SI1767545T1 (sl)	2010-03-31
EP2174952A2 (de)	2010-04-14
ES2336575T3 (es)	2010-04-14
PT1767545E (pt)	2010-02-05
AU2006299134B2 (en)	2012-02-23
US20120238497A1 (en)	2012-09-20
AU2006299134A1 (en)	2007-04-12
DE602005017628D1 (de)	2009-12-24
WO2007039140A1 (en)	2007-04-12
EP2261245A1 (de)	2010-12-15

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2017-04-13	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20160922