DK1767545T3 - GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens - Google Patents

GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens

Info

Publication number: DK1767545T3
Authority: DK; Denmark
Prior art keywords: glp; peptide; component; sequence; glucagon
Prior art date: 2005-09-22

Application number

DK05020718.2T

Other languages

English (en)

Inventor

Peter Dr Geigle

Christine Dr Wallrapp

Eric Thoenes

Original Assignee

Biocompatibles Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-22

Filing date

2005-09-22

Publication date

2010-03-15

2005-09-22 Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd

2010-03-15 Application granted granted Critical

2010-03-15 Publication of DK1767545T3 publication Critical patent/DK1767545T3/da

Links

102400000322 Glucagon-like peptide 1 Human genes 0.000 title abstract 6
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 6
108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
230000004927 fusion Effects 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
101800000224 Glucagon-like peptide 1 Proteins 0.000 title 2
102000035195 Peptidases Human genes 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
235000019833 protease Nutrition 0.000 title 1
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 1
101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
102400000326 Glucagon-like peptide 2 Human genes 0.000 abstract 1
101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
208000034615 apoptosis-related disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- G—PHYSICS
- G07—CHECKING-DEVICES
- G07F—COIN-FREED OR LIKE APPARATUS
- G07F11/00—Coin-freed apparatus for dispensing, or the like, discrete articles
- G07F11/02—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines
- G07F11/04—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines in which magazines the articles are stored one vertically above the other
- G07F11/16—Delivery means
- G07F11/165—Delivery means using xyz-picker or multi-dimensional article picking arrangements

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK05020718.2T 2005-09-22 2005-09-22 GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens DK1767545T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05020718A EP1767545B1 (en)	2005-09-22	2005-09-22	GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Publications (1)

Publication Number	Publication Date
DK1767545T3 true DK1767545T3 (da)	2010-03-15

Family

ID=35700191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05020718.2T DK1767545T3 (da)	2005-09-22	2005-09-22	GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens

Country Status (24)

Country	Link
US (2)	US8431533B2 (da)
EP (5)	EP2045265B1 (da)
JP (2)	JP5222729B2 (da)
KR (1)	KR20080064840A (da)
CN (1)	CN101273058A (da)
AT (1)	ATE448247T1 (da)
AU (1)	AU2006299134B2 (da)
BR (1)	BRPI0616107A2 (da)
CA (1)	CA2619053A1 (da)
CY (1)	CY1109778T1 (da)
DE (1)	DE602005017628D1 (da)
DK (1)	DK1767545T3 (da)
EA (1)	EA013796B1 (da)
ES (3)	ES2336575T3 (da)
HK (1)	HK1129121A1 (da)
HR (1)	HRP20100062T1 (da)
IL (1)	IL188904A0 (da)
PL (1)	PL1767545T3 (da)
PT (1)	PT1767545E (da)
RS (1)	RS51319B (da)
SG (1)	SG165414A1 (da)
SI (1)	SI1767545T1 (da)
WO (1)	WO2007039140A1 (da)
ZA (1)	ZA200803488B (da)

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EP1975176A1 (en) *	2007-03-27	2008-10-01	Biocompatibles UK Limited	Novel glp-1 fusion peptides, their production and use
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RU2584572C2 (ru) *	2010-02-11	2016-05-20	Ф.Хоффманн-Ля Рош Аг	Способ получения полипептида, конъюгированного с поли(этиленгликолевым) фрагментом, нуклеиновая кислота и слитый полипептид, предназначенные для применения в способе
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PT3155017T (pt)	2014-05-28	2024-05-14	Mederis Diabetes Llc	Farmacêuticos peptídicos melhorados para resistência à insulina
PT3257524T (pt)	2015-02-11	2020-11-27	Gmax Biopharm Llc	Preparação de solução estabilizada de proteína de fusão de anticorpo glp-1r farmacêutica
ES2968038T3 (es)	2015-12-23	2024-05-06	Univ Johns Hopkins	Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas
CN107818433B (zh) *	2016-09-14	2022-07-05	菜鸟智能物流控股有限公司	取件方法、物流信息处理方法及装置、系统
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WO2018104559A1 (en) *	2016-12-09	2018-06-14	Zealand Pharma A/S	Glp-1/glp-2 dual agonists
EP3551651B1 (en)	2016-12-09	2024-03-06	Zealand Pharma A/S	Acylated glp-1/glp-2 dual agonists
CN108341880B (zh) *	2017-01-23	2023-07-04	天津药物研究院有限公司	含有胰高血糖素样肽-1和胰高血糖素的片段类似物的嵌合多肽及其用途
KR101827245B1 (ko) *	2017-12-26	2018-02-08	(주)제이유타이드	알라린을 주성분으로 하는 요독증 치료제
HUE069178T2 (hu)	2018-01-03	2025-02-28	Mederis Diabetes Llc	Javított peptidgyógyszerek NASH és egyéb rendellenességek kezelésére
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RS63523B1 (sr)	2018-04-05	2022-09-30	Sun Pharmaceutical Ind Ltd	Novi glp-1 analozi
EP3901173A4 (en)	2018-12-21	2022-11-23	Jiangsu Hengrui Medicine Co., Ltd.	BISPECIFIC PROTEIN
US20240368239A1 (en) *	2020-03-12	2024-11-07	Sl Metagen	Novel bispecific protein and use thereof
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CN112661862B (zh) *	2020-12-25	2023-03-31	深圳大学	一种融合蛋白及其制备方法和应用
CN113846124A (zh) *	2021-09-26	2021-12-28	康霖生物科技（杭州）有限公司	一种用于糖代谢相关疾病基因治疗的核酸构建体
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Also Published As

Publication number	Publication date
JP2013099352A (ja)	2013-05-23
PL1767545T3 (pl)	2010-04-30
HK1129121A1 (en)	2009-11-20
US8853159B2 (en)	2014-10-07
HRP20100062T1 (hr)	2010-03-31
EP2045265B1 (en)	2012-11-21
JP2009508505A (ja)	2009-03-05
EP1926748A1 (en)	2008-06-04
RS51319B (sr)	2010-12-31
ES2394218T3 (es)	2013-01-23
IL188904A0 (en)	2008-04-13
EA013796B1 (ru)	2010-06-30
SG165414A1 (en)	2010-10-28
US20110130329A1 (en)	2011-06-02
JP5222729B2 (ja)	2013-06-26
ATE448247T1 (de)	2009-11-15
CY1109778T1 (el)	2014-09-10
EP2174952A3 (en)	2010-11-17
ES2397289T3 (es)	2013-03-06
CN101273058A (zh)	2008-09-24
CA2619053A1 (en)	2007-04-12
EP1926748B1 (en)	2012-08-29
EP1767545A1 (en)	2007-03-28
US8431533B2 (en)	2013-04-30
BRPI0616107A2 (pt)	2011-06-07
EP2045265A1 (en)	2009-04-08
KR20080064840A (ko)	2008-07-09
EP1767545B1 (en)	2009-11-11
EA200800699A1 (ru)	2008-10-30
ZA200803488B (en)	2009-10-28
SI1767545T1 (sl)	2010-03-31
EP2174952A2 (en)	2010-04-14
ES2336575T3 (es)	2010-04-14
PT1767545E (pt)	2010-02-05
AU2006299134B2 (en)	2012-02-23
US20120238497A1 (en)	2012-09-20
AU2006299134A1 (en)	2007-04-12
DE602005017628D1 (de)	2009-12-24
WO2007039140A1 (en)	2007-04-12
EP2261245A1 (en)	2010-12-15

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