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HK1117392A1 - Modulators of indoleamine 2,3-dioxygenase and methods of using the same - Google Patents

Modulators of indoleamine 2,3-dioxygenase and methods of using the same Download PDF

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Publication number
HK1117392A1
HK1117392A1 HK08108013.8A HK08108013A HK1117392A1 HK 1117392 A1 HK1117392 A1 HK 1117392A1 HK 08108013 A HK08108013 A HK 08108013A HK 1117392 A1 HK1117392 A1 HK 1117392A1
Authority
HK
Hong Kong
Prior art keywords
amino
methyl
fluorophenyl
oxadiazol
bromo
Prior art date
Application number
HK08108013.8A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1117392B (en
Inventor
Andrew P. Combs
Eddy W. Yue
Original Assignee
Incyte Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37396891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1117392(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of HK1117392A1 publication Critical patent/HK1117392A1/en
Publication of HK1117392B publication Critical patent/HK1117392B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/081,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK08108013.8A 2005-05-10 2006-05-09 Modulators of indoleamine 2,3-dioxygenase and methods of using the same HK1117392B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67950705P 2005-05-10 2005-05-10
US20050679507P 2005-05-10
PCT/US2006/017983 WO2006122150A1 (en) 2005-05-10 2006-05-09 Modulators of indoleamine 2,3-dioxygenase and methods of using the same

Publications (2)

Publication Number Publication Date
HK1117392A1 true HK1117392A1 (en) 2009-01-16
HK1117392B HK1117392B (en) 2013-08-09

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Also Published As

Publication number Publication date
KR101562549B1 (ko) 2015-10-23
HUE029214T2 (en) 2017-02-28
CY1117681T1 (el) 2017-05-17
AU2006244068A1 (en) 2006-11-16
JP4990270B2 (ja) 2012-08-01
EA200702455A1 (ru) 2008-04-28
IL186957A (en) 2014-04-30
BR122020016659B1 (pt) 2021-03-16
US11192868B2 (en) 2021-12-07
US8034953B2 (en) 2011-10-11
BR122020016659B8 (pt) 2021-07-27
CA2606783C (en) 2014-03-25
DK2559690T3 (en) 2016-04-25
SG195607A1 (en) 2013-12-30
CY1113989T1 (el) 2016-07-27
EA026785B1 (ru) 2017-05-31
EP2559690B1 (en) 2016-03-30
ZA200709698B (en) 2008-11-26
US20130123246A1 (en) 2013-05-16
NZ562919A (en) 2011-04-29
NO20075693L (no) 2008-02-07
NO342140B1 (no) 2018-03-26
NO340487B1 (no) 2017-05-02
US8846726B2 (en) 2014-09-30
NO20170633A1 (no) 2008-02-07
MY153424A (en) 2015-02-13
WO2006122150A1 (en) 2006-11-16
BRPI0608604A2 (pt) 2010-01-26
HRP20160537T1 (hr) 2016-06-17
KR20130109263A (ko) 2013-10-07
US20180030006A1 (en) 2018-02-01
JP2012140450A (ja) 2012-07-26
PT1879573E (pt) 2013-03-25
UA99897C2 (en) 2012-10-25
CR9485A (es) 2008-02-20
HK1182381A1 (en) 2013-11-29
PL1879573T3 (pl) 2013-05-31
US20110311479A1 (en) 2011-12-22
PT2559690T (pt) 2016-07-07
SI2559690T1 (sl) 2016-06-30
US10208002B2 (en) 2019-02-19
AU2006244068B9 (en) 2012-10-25
US20190210985A1 (en) 2019-07-11
EP1879573B1 (en) 2012-12-19
SG10201809390QA (en) 2018-11-29
EP1879573A4 (en) 2009-07-08
DK1879573T3 (da) 2013-02-25
IL186957A0 (en) 2008-02-09
CN103130735A (zh) 2013-06-05
RS54876B1 (sr) 2016-10-31
TW200719892A (en) 2007-06-01
GEP20217221B (en) 2021-02-10
BRPI0608604B8 (pt) 2021-05-25
EP1879573A1 (en) 2008-01-23
IL232313A0 (en) 2014-06-30
HRP20130220T1 (hr) 2013-04-30
ME02461B (me) 2017-02-20
PL2559690T3 (pl) 2016-09-30
SG161310A1 (en) 2010-05-27
ES2578404T3 (es) 2016-07-26
EP3085697A1 (en) 2016-10-26
JP2008540548A (ja) 2008-11-20
KR20080005954A (ko) 2008-01-15
KR101386494B1 (ko) 2014-04-24
AR054271A1 (es) 2007-06-13
CN101212967A (zh) 2008-07-02
BRPI0608604B1 (pt) 2020-11-17
AU2006244068B2 (en) 2012-06-14
JP5615308B2 (ja) 2014-10-29
RS52711B (en) 2013-08-30
MX2007013977A (es) 2008-02-05
US20140377292A1 (en) 2014-12-25
TWI377060B (en) 2012-11-21
CA2606783A1 (en) 2006-11-16
IL232313A (en) 2016-05-31
SI1879573T1 (sl) 2013-04-30
US8372870B2 (en) 2013-02-12
CN103130735B (zh) 2016-08-03
EP2559690A1 (en) 2013-02-20
US20060258719A1 (en) 2006-11-16
ES2401482T3 (es) 2013-04-22

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