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HK1085727A1 - 用於治疗高胆甾醇血的取代的氮杂环丁二烯化合物及其制剂和使用 - Google Patents

用於治疗高胆甾醇血的取代的氮杂环丁二烯化合物及其制剂和使用 Download PDF

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Publication number
HK1085727A1
HK1085727A1 HK06105697A HK06105697A HK1085727A1 HK 1085727 A1 HK1085727 A1 HK 1085727A1 HK 06105697 A HK06105697 A HK 06105697A HK 06105697 A HK06105697 A HK 06105697A HK 1085727 A1 HK1085727 A1 HK 1085727A1
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HK
Hong Kong
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alkylene
alkyl
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independently selected
aryl
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HK06105697A
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German (de)
English (en)
French (fr)
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HK1085727B (zh
Inventor
杜纳.A.伯内特
约翰.W.克劳德
丰恩.威克罗
Original Assignee
Merck Sharp & Dohme Corp.
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Publication of HK1085727A1 publication Critical patent/HK1085727A1/zh
Publication of HK1085727B publication Critical patent/HK1085727B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/28Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06105697.9A 2003-03-07 2004-03-03 用於治療高膽甾醇血的取代的氮雜環丁二烯化合物及其製劑和使用 HK1085727B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45280903P 2003-03-07 2003-03-07
US60/452,809 2003-03-07
PCT/US2004/006546 WO2004081002A1 (en) 2003-03-07 2004-03-03 Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia

Publications (2)

Publication Number Publication Date
HK1085727A1 true HK1085727A1 (zh) 2006-09-01
HK1085727B HK1085727B (zh) 2009-02-13

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Also Published As

Publication number Publication date
US7368562B2 (en) 2008-05-06
EP1601668B1 (en) 2008-08-27
US20070155674A1 (en) 2007-07-05
DE602004016123D1 (de) 2008-10-09
US7741289B2 (en) 2010-06-22
CN100439361C (zh) 2008-12-03
US7235543B2 (en) 2007-06-26
MXPA05009503A (es) 2005-10-18
ATE406364T1 (de) 2008-09-15
CA2517571A1 (en) 2004-09-23
WO2004081002A1 (en) 2004-09-23
US20040198700A1 (en) 2004-10-07
ES2311806T3 (es) 2009-02-16
CA2517571C (en) 2011-07-05
US7368563B2 (en) 2008-05-06
US20080207585A1 (en) 2008-08-28
JP5137228B2 (ja) 2013-02-06
EP1601668A1 (en) 2005-12-07
US20070155675A1 (en) 2007-07-05
CN1756752A (zh) 2006-04-05
JP2006520822A (ja) 2006-09-14

Similar Documents

Publication Publication Date Title
US7741289B2 (en) Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7732413B2 (en) Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1606287B1 (en) Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US20040097482A1 (en) Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
US7459442B2 (en) Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1810971B1 (en) Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
HK1085727B (zh) 用於治療高膽甾醇血的取代的氮雜環丁二烯化合物及其製劑和使用
HK1109618A (zh) 取代的2-吖丁啶酮化合物、其製劑及其治療高膽甾醇血症的用途
HK1085728B (zh) 用於治療高膽甾醇血的取代的氮雜環丁二烯化合物及其製劑和使用

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140303