HK1072905A1 - Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof - Google Patents

Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof

Info

Publication number: HK1072905A1
Authority: HK; Hong Kong
Prior art keywords: derivatives; carboxylic acids; sub; site; action
Prior art date: 2002-05-14

Application number

HK05106618.4A

Other languages

English (en)

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-14

Filing date

2005-08-02

Publication date

2005-09-16

2005-08-02 Application filed by Univ California filed Critical Univ California

2005-09-16 Publication of HK1072905A1 publication Critical patent/HK1072905A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK05106618.4A 2002-05-14 2005-08-02 Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof HK1072905A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38064102P	2002-05-14	2002-05-14
PCT/US2003/014948 WO2003097564A2 (en)	2002-05-14	2003-05-12	Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof

Publications (1)

Publication Number	Publication Date
HK1072905A1 true HK1072905A1 (en)	2005-09-16

Family

ID=29549994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK05106618.4A HK1072905A1 (en)	2002-05-14	2005-08-02	Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof

Country Status (17)

Country	Link
US (2)	US7355047B2 (xx)
EP (1)	EP1503759B1 (xx)
JP (1)	JP4532263B2 (xx)
KR (1)	KR20040107525A (xx)
CN (1)	CN1652784A (xx)
AT (1)	ATE417613T1 (xx)
AU (1)	AU2003229043B2 (xx)
BR (1)	BR0309965A (xx)
CA (1)	CA2484308A1 (xx)
DE (1)	DE60325347D1 (xx)
DK (1)	DK1503759T3 (xx)
ES (1)	ES2319176T3 (xx)
HK (1)	HK1072905A1 (xx)
IL (1)	IL164734A0 (xx)
MX (1)	MXPA04011156A (xx)
NZ (1)	NZ536061A (xx)
WO (1)	WO2003097564A2 (xx)

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US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
BR0309965A (pt) *	2002-05-14	2005-03-01	Univ California	ácidos carboxìlicos com quinolona substituìda, seus derivados, local de ação, e usos dos mesmos
DE102004004971B3 (de) *	2004-01-31	2005-09-15	Aventis Pharma Deutschland Gmbh	Cycloalkyl substituierte 7-Amino-4-chinolon-3-carbonsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arnzeimittel
US7470706B2 (en)	2004-01-31	2008-12-30	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
US7825278B2 (en) *	2004-05-06	2010-11-02	The Regents Of The University Of California	Substituted enaminones, their derivatives and uses thereof
DK2502911T3 (en) *	2004-06-24	2017-06-06	Vertex Pharma	Modulators of ATP-binding cassette transporters
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
JP4796622B2 (ja) *	2005-04-11	2011-10-19	エフ．ホフマン−ラロシュアーゲー	（３，４−ジヒドロ−キナゾリン−２−イル）−インダン−１−イル−アミン
EP1888538B1 (en) *	2005-05-04	2009-11-18	F. Hoffmann-Roche AG	(3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amines having an activity on the 5-ht receptor
AU2006322045A1 (en) *	2005-12-05	2007-06-14	Merck & Co., Inc.	Quinolone M1 receptor positive allosteric modulators
CA2634113A1 (en) *	2005-12-24	2007-07-05	Vertex Pharmaceuticals Incorporated	Quinolin- 4 - one derivatives as modulators of abc transporters
LT1993360T (lt)	2005-12-28	2017-06-12	Vertex Pharmaceuticals Incorporated	N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
CN101443314B (zh) *	2006-03-13	2014-04-09	杏林制药株式会社	作为gsk-3抑制剂的氨基喹诺酮类
KR20090035744A (ko) *	2006-08-10	2009-04-10	페레르 인터내쇼날 에스.에이.	Ｇａｂａ 수용체의 친화력을 갖는 1ｈ-퀴놀린-4-원 화합물,제조방법, 사용방법 및 조성물
EP1886996A1 (en) *	2006-08-10	2008-02-13	Ferrer Internacional, S.A.	1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
US10954231B2 (en)	2006-10-16	2021-03-23	Bionomics Limited	Anxiolytic compounds
WO2008046135A1 (en)	2006-10-16	2008-04-24	Bionomics Limited	Novel anxiolytic compounds
WO2009040377A2 (en) *	2007-09-27	2009-04-02	Ge Healthcare Limited	Imaging agents
JP2012506857A (ja) *	2008-10-23	2012-03-22	メルク・シャープ・エンド・ドーム・コーポレイション	縮合複素環式ｍ１受容体ポジティブアロステリック調節因子
RU2543714C2 (ru)	2009-03-20	2015-03-10	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения модуляторов регулятора трансмембранной проводимости кистозного фиброза
US20120093917A1 (en) *	2009-04-02	2012-04-19	Robert Hromas	Metnase and intnase inhibitors and their use in treating cancer
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
EP2680842A4 (en) *	2011-03-02	2014-10-29	Bionomics Ltd	METHOD FOR THE TREATMENT OF A DISEASE OR A SENSE OF THE CENTRAL NERVOUS SYSTEM
CN103502219A (zh)	2011-03-02	2014-01-08	生态学有限公司	作为治疗剂的新型小分子
CN103649086A (zh)	2011-05-12	2014-03-19	生态学有限公司	制备萘啶的方法
BR112014021090B1 (pt)	2012-02-27	2023-01-24	Vertex Pharmaceuticals Incorporated	Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma
RU2749213C2 (ru)	2014-10-07	2021-06-07	Вертекс Фармасьютикалз Инкорпорейтед	Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе
CN107501107A (zh) *	2017-09-26	2017-12-22	兰亚朝	喹诺酮药物的中间体合成方法
CN111269131B (zh) *	2020-03-12	2021-12-28	江苏飞宇医药科技股份有限公司	以三正丙胺为吸酸剂制备环丙乙酯胺化物的工艺

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GB1433774A (en) *	1973-02-26	1976-04-28	Allen & Hanburys Ltd	Heterocyclic compounds apparatus for conveying articles
JPS5715760B2 (xx) *	1974-06-11	1982-04-01
US4390541A (en) *	1980-12-19	1983-06-28	Lilly Industries Limited	Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
US6248739B1 (en) *	1999-01-08	2001-06-19	Pharmacia & Upjohn Company	Quinolinecarboxamides as antiviral agents
MXPA01011173A (es) *	1999-05-06	2002-04-24	Neurogen Corp	4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba.
GB0127349D0 (en) *	2001-11-14	2002-01-02	Glaxo Group Ltd	Macrolides
BR0309965A (pt) *	2002-05-14	2005-03-01	Univ California	ácidos carboxìlicos com quinolona substituìda, seus derivados, local de ação, e usos dos mesmos

2003
- 2003-05-12 BR BR0309965-2A patent/BR0309965A/pt not_active IP Right Cessation
- 2003-05-12 WO PCT/US2003/014948 patent/WO2003097564A2/en active Application Filing
- 2003-05-12 DK DK03726824T patent/DK1503759T3/da active
- 2003-05-12 JP JP2004505299A patent/JP4532263B2/ja not_active Expired - Fee Related
- 2003-05-12 AU AU2003229043A patent/AU2003229043B2/en not_active Ceased
- 2003-05-12 EP EP03726824A patent/EP1503759B1/en not_active Expired - Lifetime
- 2003-05-12 DE DE60325347T patent/DE60325347D1/de not_active Expired - Lifetime
- 2003-05-12 CA CA002484308A patent/CA2484308A1/en not_active Abandoned
- 2003-05-12 KR KR10-2004-7018340A patent/KR20040107525A/ko not_active Application Discontinuation
- 2003-05-12 CN CNA03810816XA patent/CN1652784A/zh active Pending
- 2003-05-12 ES ES03726824T patent/ES2319176T3/es not_active Expired - Lifetime
- 2003-05-12 AT AT03726824T patent/ATE417613T1/de not_active IP Right Cessation
- 2003-05-12 US US10/514,808 patent/US7355047B2/en not_active Expired - Fee Related
- 2003-05-12 NZ NZ536061A patent/NZ536061A/en unknown
- 2003-05-12 MX MXPA04011156A patent/MXPA04011156A/es active IP Right Grant
2004
- 2004-10-20 IL IL16473404A patent/IL164734A0/xx unknown
2005
- 2005-08-02 HK HK05106618.4A patent/HK1072905A1/xx not_active IP Right Cessation
2008
- 2008-02-15 US US12/032,403 patent/US20080176897A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ536061A (en)	2008-09-26
DE60325347D1 (de)	2009-01-29
KR20040107525A (ko)	2004-12-20
JP2005535592A (ja)	2005-11-24
DK1503759T3 (da)	2009-04-14
US20060178516A1 (en)	2006-08-10
ES2319176T3 (es)	2009-05-05
CN1652784A (zh)	2005-08-10
ATE417613T1 (de)	2009-01-15
EP1503759A4 (en)	2006-02-15
AU2003229043B2 (en)	2008-12-04
US20080176897A1 (en)	2008-07-24
IL164734A0 (en)	2005-12-18
JP4532263B2 (ja)	2010-08-25
AU2003229043A1 (en)	2003-12-02
EP1503759A2 (en)	2005-02-09
WO2003097564A3 (en)	2004-02-26
EP1503759B1 (en)	2008-12-17
BR0309965A (pt)	2005-03-01
CA2484308A1 (en)	2003-11-27
WO2003097564A2 (en)	2003-11-27
MXPA04011156A (es)	2005-02-17
US7355047B2 (en)	2008-04-08

Publication	Publication Date	Title
HK1072905A1 (en)	2005-09-16	Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
HK1039939A1 (zh)	2002-05-17	α-取代羧酸衍生物
IL158923A0 (en)	2004-05-12	Fluoropyrrolidines as dipeptidyl peptidase inhibitors
AU2002316437A1 (en)	2003-03-03	Pyrrolidines as dipeptidyl peptidase inhibitors
AP2005003418A0 (en)	2005-12-31	Alpha substituted carboxylic acids as ppar modulators.
AU2002362482A1 (en)	2003-04-14	Acne treatment using oleanolic acid
WO2004031374A3 (en)	2004-08-12	Secondary binding site of dipeptidyl peptidase iv (dp iv)
AU2003286700A1 (en)	2004-06-07	DERIVATIVES OF (6,7-DIHYDRO-5H-IMIDAZO(1,2-Alpha)IMIDAZOLE-3-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE AS ANTI-INFLAMMATORY AGENTS
DK1311256T3 (da)	2005-11-28	Anvendelse af derivater af valproinsyreamider og 2-valproinsyreamider til behandling eller forebyggelse af smerter og/eller hovedpinelidelser
WO2003032912A3 (en)	2003-12-11	Treatment of cns disorders using cns target modulators
WO2001083438A3 (en)	2002-06-13	New gamma selective retinoids
HK1025517A1 (en)	2000-11-17	The use of quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and the associated gastroduodenal diseases
NO20065595L (no)	2007-02-02	Substituerte enaminoner, deres derivater og anvendelse derav.
AU2003304226A1 (en)	2005-01-04	Inhibition of rosin crystallization
AU6689900A (en)	2001-02-05	3-arylsulfonyl-2-(substituted methyl)propanoic acid derivates as matrix metalloproteinase inhibitors
BG104801A (en)	2001-04-30	Indole-2,3-dione-3-oxime derivatives for therapeutical use
HK1042705B (zh)	2005-03-11	B晶型8-氰基-1-環丙基-7-(1s，6s-2，8-二氮雜二環[4‧3‧0]壬烷-8-基)-6-氟-1，4-二氫-4-氧代-3-喹啉羧酸
AU2003258050A1 (en)	2004-05-04	5-cycloalkenyl 5h-chromeno(3,4-f)quinoline derivatives as selective progesterone receptor modulator compounds
DE602004003173D1 (de)	2006-12-28	Verwendung von konjugierter Linolsäure zur Behandlung der Erkältung
WO2003045917A3 (en)	2003-10-09	Ccr-3 receptor antagonists vii
NO20014059L (no)	2001-08-21	Krystallmodifikasjon D av 8-cyano-1-cyklopropyl-7-(1S,6S-2,8- diazabicyklo-/4.3.0/-nonan-8-yl)-6-fluor-1,4-dihydro-4-okso-3-kinolinkarboksylsyre
DE59909262D1 (de)	2004-05-27	Kristallmodifikation a von 8-cyan-1- cyclopropyl-7- (1s,6s-2,8 -diazabicyclo - 4.3.0]nonan -8-yl)-6- fluor-1,4- dihydro-4- oxo-3- chinolincarbonsäure
WO2003106385A3 (en)	2004-07-01	METHOD FOR SCREENING FUNGITOXIC COMPOUNDS
AU4634999A (en)	2000-01-24	Cinnamic acid derivatives as cell adhesion molecules
AU2002367951A1 (en)	2003-12-02	THE USE OF THE INHIBITOR TRANSMITTER OF Gamma-AMINOBUTYRIC ACID (GABA) IN THE MANUFACTURE OF ANALGESIC

Legal Events

Date	Code	Title	Description
2013-12-06	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20130512