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HK1063188A1 - Peptide for the diagnosis and therapy of alzeimer's disease - Google Patents

Peptide for the diagnosis and therapy of alzeimer's disease

Info

Publication number
HK1063188A1
HK1063188A1 HK04105028A HK04105028A HK1063188A1 HK 1063188 A1 HK1063188 A1 HK 1063188A1 HK 04105028 A HK04105028 A HK 04105028A HK 04105028 A HK04105028 A HK 04105028A HK 1063188 A1 HK1063188 A1 HK 1063188A1
Authority
HK
Hong Kong
Prior art keywords
diagnosis
therapy
disease
peptide
alzeimer
Prior art date
Application number
HK04105028A
Inventor
Dieter Willbold
Katja Wiesehan
Original Assignee
Leibniz Inst Fur Altersforschu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leibniz Inst Fur Altersforschu filed Critical Leibniz Inst Fur Altersforschu
Publication of HK1063188A1 publication Critical patent/HK1063188A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to peptides which bind to the peptide beta -amyloid with a high binding affinity. The invention also relates to a method for producing said peptides in addition to the use of said peptides for the diagnosis and therapy of Alzheimer's disease.
HK04105028A 2001-04-06 2004-07-09 Peptide for the diagnosis and therapy of alzeimer's disease HK1063188A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10117281A DE10117281A1 (en) 2001-04-06 2001-04-06 Peptide for the diagnosis and therapy of Alzheimer's dementia
PCT/EP2002/003862 WO2002081505A2 (en) 2001-04-06 2002-04-08 Peptide for the diagnosis and therapy of alzheimer's disease

Publications (1)

Publication Number Publication Date
HK1063188A1 true HK1063188A1 (en) 2004-12-17

Family

ID=7680694

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04105028A HK1063188A1 (en) 2001-04-06 2004-07-09 Peptide for the diagnosis and therapy of alzeimer's disease

Country Status (6)

Country Link
EP (1) EP1379546B1 (en)
AT (1) ATE364623T1 (en)
DE (2) DE10117281A1 (en)
ES (1) ES2289110T3 (en)
HK (1) HK1063188A1 (en)
WO (1) WO2002081505A2 (en)

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US20030108539A1 (en) * 2000-02-14 2003-06-12 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
JP2005525096A (en) * 2002-01-09 2005-08-25 ユニバーシティ オブ ローザンヌ Cell penetrating peptide inhibitors of the JNK signaling pathway
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
PL1976877T5 (en) 2005-11-30 2017-09-29 Abbvie Inc Monoclonal antibodies against amyloid beta protein and uses thereof
ES2527661T3 (en) 2005-11-30 2015-01-28 Abbvie Inc. Scanning method, process for purifying non-spreadable Abeta oligomers, selective antibodies against said spreadable Abeta oligomers and a process for making said antibodies
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
DE102008037564A1 (en) * 2008-11-19 2010-05-20 Forschungszentrum Jülich GmbH Composition for the production of anti-amyloid beta-peptide antibodies with D-peptides
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
CA2796339C (en) 2010-04-15 2020-03-31 Abbott Laboratories Amyloid-beta binding proteins
DE102010019336A1 (en) 2010-05-05 2011-11-10 Forschungszentrum Jülich GmbH Agent for the treatment of Alzheimer's dementia
DE102010017130B4 (en) 2010-05-28 2018-11-29 Forschungszentrum Jülich GmbH Hybrid compound, its use and process for its preparation
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
CA2808187A1 (en) 2010-08-14 2012-02-23 Abbvie Inc. Amyloid-beta binding proteins
US9150618B2 (en) 2010-10-14 2015-10-06 Xigen Inflammation Ltd. Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
DE102012108598A1 (en) * 2012-09-14 2014-04-10 Forschungszentrum Jülich GmbH New D3-D enantiomeric peptides derived from D3 and their use
DK2834643T3 (en) * 2012-04-05 2020-02-03 Forschungszentrum Juelich Gmbh METHOD OF TREATING BLOOD, BLOOD PRODUCTS AND BODIES
DE102012102998B4 (en) 2012-04-05 2013-12-05 Forschungszentrum Jülich GmbH New polymer comprising two substances that bind to amyloid-beta-oligomers, useful for treating Alzheimer's disease, Parkinson's disease, Creutzfeldt Jakob disease or diabetes
DE102012108599B4 (en) 2012-09-14 2023-06-01 Priavoid Gmbh A-beta oligomer-binding peptides and their use
CN107652356A (en) * 2012-04-05 2018-02-02 于利希研究中心有限公司 The polymer of D peptides comprising multivalence combination amyloid beta protein and its application
DE102012102999A1 (en) * 2012-04-05 2013-10-10 Forschungszentrum Jülich GmbH Treating blood, blood products and/or organs under in vitro, and ex vivo condition, involves obtaining blood, blood products and/or organs from human or animal body and removing amyloid beta oligomers from products
DE102012019882A1 (en) 2012-10-05 2014-04-10 Forschungszentrum Jülich GmbH Peptides for the treatment and early diagnosis of Alzheimer's disease and other tauopathies
DE102012022013A1 (en) * 2012-11-02 2014-05-08 Forschungszentrum Jülich GmbH Fachbereich Patente Peptides that bind to amino-terminal truncated amyloid beta-peptide and their use
DE102013007405A1 (en) * 2013-04-30 2014-11-13 Forschungszentrum Jülich GmbH Agents for the prevention and treatment of HIV and other viral infections
DE102014003262A1 (en) 2014-03-12 2015-09-17 Forschungszentrum Jülich GmbH Amyloid beta-binding peptides and their use for the therapy and diagnosis of Alzheimer's dementia
DK2991664T3 (en) 2013-04-30 2019-12-02 Forschungszentrum Juelich Gmbh Means for the prevention and treatment of sequelae of HIV and other viral infections
DE102013016002A1 (en) 2013-09-26 2015-03-26 Forschungszentrum Jülich GmbH Cyclic amyloid beta-binding peptides and their use
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
KR20160023669A (en) 2013-06-26 2016-03-03 자이겐 인플라메이션 리미티드 New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
JP6660877B2 (en) 2013-09-26 2020-03-11 フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Amyloid-β-binding peptide and its use for the treatment and diagnosis of Alzheimer's dementia
DE102015003503A1 (en) 2015-03-20 2016-09-22 Forschungszentrum Jülich GmbH Specifically, amyloid beta-binding peptides and their use for the therapy and diagnosis of Alzheimer's dementia
DE102015003676A1 (en) * 2015-03-20 2016-09-22 Forschungszentrum Jülich GmbH Fachbereich Patente Specifically A-beta species-binding peptides for the therapy and / or diagnosis of Alzheimer's dementia
DE102016125645A1 (en) * 2016-12-23 2018-06-28 Forschungszentrum Jülich GmbH D-enantiomeric peptides for the treatment of chronic and neuropathic pain
CN111201030B (en) 2017-07-25 2024-11-01 真和制药有限公司 Treatment of cancer by blocking the interaction of TIM-3 and its ligands

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Publication number Priority date Publication date Assignee Title
US5985242A (en) * 1995-10-27 1999-11-16 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
US6420110B1 (en) * 1998-10-19 2002-07-16 Gpc Biotech, Inc. Methods and reagents for isolating biologically active peptides
DK1161449T3 (en) * 1999-03-04 2007-11-05 Praecis Pharm Inc Modulators of beta-amyloid peptide aggregation comprising d-amino acids
AU4529800A (en) * 1999-05-05 2000-11-21 Neurochem, Inc. Stereoselective antifibrillogenic peptides and peptidomimetics thereof
GB9917725D0 (en) * 1999-07-28 1999-09-29 Medical Res Council Peptides

Also Published As

Publication number Publication date
ATE364623T1 (en) 2007-07-15
WO2002081505A2 (en) 2002-10-17
DE50210317D1 (en) 2007-07-26
EP1379546B1 (en) 2007-06-13
EP1379546A2 (en) 2004-01-14
ES2289110T3 (en) 2008-02-01
WO2002081505A3 (en) 2003-10-23
DE10117281A1 (en) 2002-10-24

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130408