[go: up one dir, main page]

WO2001002429A3 - Angiopoietin-6 and uses thereof - Google Patents

Angiopoietin-6 and uses thereof Download PDF

Info

Publication number
WO2001002429A3
WO2001002429A3 PCT/EP2000/006002 EP0006002W WO0102429A3 WO 2001002429 A3 WO2001002429 A3 WO 2001002429A3 EP 0006002 W EP0006002 W EP 0006002W WO 0102429 A3 WO0102429 A3 WO 0102429A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
protein
ang
angiopoietin
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/006002
Other languages
French (fr)
Other versions
WO2001002429A2 (en
Inventor
Gustav Hagen
Gabi Friedrich
Maresa Wick
Dmitri Zubov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU59793/00A priority Critical patent/AU5979300A/en
Publication of WO2001002429A2 publication Critical patent/WO2001002429A2/en
Publication of WO2001002429A3 publication Critical patent/WO2001002429A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides a nucleic acid molecule encoding human Angiopoietin-6 (Ang-6) protein. In addition the invention provides methods for producing recombinant human Ang-6 protein. The invention also provides an antibody which specifically binds human Ang-6 protein. The invention further provides for therapeutic compositions.
PCT/EP2000/006002 1999-07-02 2000-06-28 Angiopoietin-6 and uses thereof Ceased WO2001002429A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59793/00A AU5979300A (en) 1999-07-02 2000-06-28 Angiopoietin-6 and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99113503 1999-07-02
EP99113503.9 1999-07-02

Publications (2)

Publication Number Publication Date
WO2001002429A2 WO2001002429A2 (en) 2001-01-11
WO2001002429A3 true WO2001002429A3 (en) 2001-03-15

Family

ID=8238584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006002 Ceased WO2001002429A2 (en) 1999-07-02 2000-06-28 Angiopoietin-6 and uses thereof

Country Status (2)

Country Link
AU (1) AU5979300A (en)
WO (1) WO2001002429A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1484401A1 (en) * 1999-07-20 2004-12-08 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
ZA200701183B (en) 2004-07-20 2008-05-28 Genentech Inc Inhibitors of angiopoietin-like 4 protein, combinations, an their use
CA2574791A1 (en) 2004-07-20 2006-02-09 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015654A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie receptor tyrosine kinase ligand homologues
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015654A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie receptor tyrosine kinase ligand homologues
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENEMBL 30 June 1999 (1999-06-30), KIM ET AL.: "Homo sapiens angiopoietein-related protein mRNA, complete cds", XP002154528 *
DATABASE GENEMBL 7 April 2000 (2000-04-07), KIM ET AL.: "Homo sapiens hepatic angiopoietin-related protein (ANGPTL2) mRNA, complete cds.", XP002154529 *
KIM ET AL.: "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis", BIOCHEM. J., vol. 346, no. 3, 15 March 2000 (2000-03-15), pages 603 - 610, XP000971125 *

Also Published As

Publication number Publication date
AU5979300A (en) 2001-01-22
WO2001002429A2 (en) 2001-01-11

Similar Documents

Publication Publication Date Title
WO2003070760A3 (en) Anti-amyloid beta antibodies and their use
AU2002217010A1 (en) Peptides, the production and use thereof for binding immunoglobulins
NZ503763A (en) Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
WO2002020569A3 (en) Mammalian genes; related reagents and methods
WO2005051998A3 (en) Antibodies binding to a c-terminal fragment of apolipoprotein e
WO2002059315A3 (en) Human nucleic acids and polypeptides and methods of use thereof
WO2001057219A3 (en) Mammalian interleukin-1-delta and -epsilon. their use in therapeutic and diagnostic methods
WO2003016551A3 (en) Novel salicylic acid-binding protein encoding nucleic acid, sabp2, and methods of use thereof
AU2002365269A1 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
WO2001002429A3 (en) Angiopoietin-6 and uses thereof
WO2004020588A3 (en) Transferrin fusion protein libraries
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
WO2001059120A3 (en) Il-17 like molecules and uses thereof
WO2003020759A3 (en) A caspase- 8 binding protein, its preparation and use
EP0816498A3 (en) Excitatory amino acid receptor protein and related nucleic acid compounds
AU2002250254A1 (en) Nucleic acids, proteins, and antibodies
WO2002044366A3 (en) Retina-specific human proteins c70rf9, c120rf7, mpp4 and f379
WO2003033675A3 (en) Identification of binding partners for specific proteins
AU2002337248A1 (en) Nucleic acids coding for novel fbox proteins, their diagnostic and therapeutic uses
AU2003226907A1 (en) Method for the preparation of recombinant mammalian heparin-binding protein (hbp)
AU2001292326A1 (en) Nucleic acid of novel human kinesin-associated gene, protein encoded by the nucleic acid, peptide fragment thereof and anticancer agents comprising the nucleic acid and the like
AU2002365925A1 (en) Rsv proteins, antibodies, compositions, methods and uses
WO2002036633A3 (en) Human 7tm proteins and polynucleotides encoding the same
AU2002250273A1 (en) Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof
AU2002257052A8 (en) Reg-like protein immunoglobulin derived proteins, compositions, methods and uses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP