HK1056116A1 - Sucrose ester c-20 to c-28 alcohol formulation - Google Patents

Sucrose ester c-20 to c-28 alcohol formulation

Info

Publication number: HK1056116A1
Authority: HK; Hong Kong
Prior art keywords: sucrose ester; sucrose; alcohol formulation; formulation; alcohol
Prior art date: 1993-12-13

Application number

HK03108374A

Other languages

English (en)

Inventor

David H Katz

Mohammed H Khalil

Laura E Pipe

John F Marcelletti

Lee R Katz

Original Assignee

Avanir Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-13

Filing date

2003-11-17

Publication date

2004-02-06

2003-11-17 Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals

2004-02-06 Publication of HK1056116A1 publication Critical patent/HK1056116A1/xx

Links

229930006000 Sucrose Natural products 0.000 title abstract 3
-1 Sucrose ester Chemical class 0.000 title abstract 3
239000005720 sucrose Substances 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
238000009472 formulation Methods 0.000 title 1
NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 abstract 2
230000001225 therapeutic effect Effects 0.000 abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 abstract 1
229940071160 cocoate Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000006071 cream Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Oil, Petroleum & Natural Gas (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

HK03108374A 1993-12-13 2003-11-17 Sucrose ester c-20 to c-28 alcohol formulation HK1056116A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16652393A	1993-12-13	1993-12-13

Publications (1)

Publication Number	Publication Date
HK1056116A1 true HK1056116A1 (en)	2004-02-06

Family

ID=22603672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK03108374A HK1056116A1 (en)	1993-12-13	2003-11-17	Sucrose ester c-20 to c-28 alcohol formulation

Country Status (15)

Country	Link
US (1)	US5534554A (de)
EP (2)	EP0738141B1 (de)
JP (2)	JP4149511B2 (de)
KR (1)	KR100322507B1 (de)
CN (2)	CN1103586C (de)
AT (2)	ATE383848T1 (de)
AU (1)	AU693476B2 (de)
CA (1)	CA2156063C (de)
DE (2)	DE69435067T2 (de)
DK (2)	DK0738141T3 (de)
ES (2)	ES2299173T3 (de)
HK (1)	HK1056116A1 (de)
PT (2)	PT1473031E (de)
SG (1)	SG43833A1 (de)
WO (1)	WO1995016434A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2710854B1 (fr) *	1993-10-08	1995-12-01	Oreal	Emulsion huile-dans-eau utilisable pour l'obtention d'une crème.
AU780340B2 (en) *	1996-09-17	2005-03-17	Avanir Pharmaceuticals	Viral inhibition by long-chain alcohols, alkanes, fatty acids and amides
US5952392A (en) *	1996-09-17	1999-09-14	Avanir Pharmaceuticals	Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en)	1996-09-17	2002-08-27	Avanir Pharmaceuticals	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
ES2245004T3 (es) *	1996-09-17	2005-12-16	Avanir Pharmaceuticals	Inhibicion viral mediante alcoholes, alcanos, acidos grasos y amidas de cadena larga.
WO1998026771A1 (en) *	1996-12-17	1998-06-25	Lidak Pharmaceuticals	Use of c18 to c26 aliphatic alcohols for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
US5948822A (en)	1996-12-17	1999-09-07	Lidak Pharmaceuticals	Treatment of hyperproliferative skin disorders with C18 to C26 alphatic alcohols
DE19718777A1 (de) *	1997-05-03	1998-11-05	Beiersdorf Ag	Verwendung von Estern aus Fettsäuren und Di- und Oligosacchariden gegen die Adhäsion von Mikroorganismen
US6046244A (en) *	1997-11-05	2000-04-04	Nexmed Holdings, Inc.	Topical compositions for prostaglandin E1 delivery
US6414028B1 (en)	1997-11-05	2002-07-02	Nexmed Holdings, Inc.	Topical compositions containing prostaglandin E1
US20050203187A1 (en) *	1998-06-01	2005-09-15	Verbiscar Anthony J.	Formulations useful for the treatment of varicella zoster virus infections and methods for the use thereof
ITMI981528A1 (it) *	1998-07-03	2000-01-03	Recordati Ind Chimica E Farma	Formulazioni topiche di aciclovir
NZ506676A (en)	1999-09-03	2002-09-27	Thomas Harting	Recovery of pure sterols from black liquor soap skimmings or tall oil pitch
DK1121928T3 (da) *	2000-01-31	2008-03-17	Haerting S A	Sammensætninger indeholdende phytosterol- og policosanolestere af fedtsyrer til reduktion af niveauet af blodcholesterol og -triglycerider
PT102410A (pt) *	2000-02-03	2001-08-30	Qualitas Lab	Extraccao da fraccao ceroide do residuo resinoso de fabricacao de aglomerado negro de cortica com fluido supercritico
US7399790B2 (en)	2001-02-28	2008-07-15	Konowalchuk Thomas W	Virucidal compositions
CN1633306A (zh) *	2001-10-16	2005-06-29	阿文尼尔药品公司	正－二十二烷醇的病毒抑制
US6559182B1 (en) *	2001-11-07	2003-05-06	Purcell Jojoba International, Llc	Method for treatment of enveloped viruses using jojoba oil esters
US7214394B2 (en) *	2002-05-31	2007-05-08	Archer-Daniels-Midland Company	Policosanol compositions, extraction from novel sources, and uses thereof
GB0313830D0 (en) *	2003-06-16	2003-07-23	Unichema Chemie Bv	Surfactant composition
US20050074443A1 (en) *	2003-10-03	2005-04-07	Treadwell Benjamin V.	Methods of attenuating autoimmune disease and compositions useful therefor
EP2132215B1 (de)	2007-02-28	2015-09-23	The Governors of the University of Alberta	Stoffe zur vorbeugung oder behandlung von viralen infektionen und deren verwendung
US8715715B2 (en)	2008-11-03	2014-05-06	Nal Pharmaceuticals Ltd.	Dosage form for insertion into the mouth
US20100209484A1 (en) *	2009-02-13	2010-08-19	Hoo-Kyun Choi	Transdermal Triptan Delivery System
FR2949329B1 (fr) *	2009-08-31	2011-10-21	Oreal	Composition cosmetique comprenant un alcane lineaire volatil et un ester de sucrose
CN102049050B (zh) *	2009-11-02	2014-06-18	重庆华邦制药有限公司	抗疱疹病毒感染的药物组合物
GB201207781D0 (en)	2012-05-03	2012-06-13	Restoration Of Appearance And Function Trust	Extracellular matrix - synthetic skin scaffold
CN103877019B (zh) *	2013-10-31	2016-01-06	湖北科益药业股份有限公司	一种二十二醇乳膏
WO2022132518A1 (en) *	2020-12-14	2022-06-23	The Procter & Gamble Company	Method of manufacturing cosmetic compositions comprising sucrose esters and solvents
CN116583264A (zh) *	2020-12-14	2023-08-11	宝洁公司	包含蔗糖酯和溶剂的化妆品组合物
WO2024261713A1 (en)	2023-06-23	2024-12-26	Haleon UK IP Limited	Topical regimen for treating cold sores

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1459233A (en) *	1973-08-29	1976-12-22	Inst Rech Chim Biolog	Medicament containing a higher alkanol
US4200655A (en) *	1978-08-15	1980-04-29	Sterling Drug Inc.	Benzyl alcohol virucidal process
FR2492829A1 (fr) *	1980-10-24	1982-04-30	Oreal	Agents de surface non-ioniques derives du glucose, procede pour les preparer et compositions les contenant
US4536519A (en) *	1981-06-15	1985-08-20	Kao Soap Co., Ltd.	Emulsifying agent and emulsified cosmetics
US4670471A (en) *	1981-11-03	1987-06-02	Clark Lealand L	Treatment for inflammatory skin disease
DE3318989C2 (de) *	1982-05-28	1996-11-21	Eisai Co Ltd	ß,gamma-Dihydropolyprenylalkoholderivate und diese enthaltende Arzneimittel und deren Verwendung
DE3586747D1 (de) *	1984-03-05	1992-11-19	Tonfer Inc	Reinigungsmittel.
US4684479A (en) *	1985-08-14	1987-08-04	Arrigo Joseph S D	Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
JPH0816066B2 (ja) *	1986-07-18	1996-02-21	エーザイ株式会社	持続性薬効製剤
JPS63179817A (ja) *	1987-01-19	1988-07-23	Kobayashi Kooc:Kk	水性クレンジング料
US4865848A (en) *	1987-02-26	1989-09-12	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4900555A (en) *	1987-02-26	1990-02-13	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4940586A (en) *	1987-02-26	1990-07-10	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US5070107A (en) *	1989-04-28	1991-12-03	Lidak Pharmaceuticals	Systemic antiviral treatment
US4874794A (en) *	1989-04-28	1989-10-17	Lidak Biopharmaceuticals	Inflammatory disease treatment
US4956171A (en) *	1989-07-21	1990-09-11	Paco Pharmaceutical Services, Inc.	Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US5166219A (en) *	1989-11-02	1992-11-24	Lidak Pharmaceuticals	Systemic anti-inflammatory treatment
US5194451A (en) *	1989-11-02	1993-03-16	Katz David H	Systemic anti-inflammatory treatment
JPH03157349A (ja) *	1989-11-14	1991-07-05	Lion Corp	乳化組成物
US5214071A (en) *	1991-04-23	1993-05-25	Summit Technology, Inc.	Corneal treatment agents
US5098896A (en) *	1991-04-23	1992-03-24	Summit Technology, Inc.	Corneal treatment agents
GB9204388D0 (en) *	1992-02-29	1992-04-15	Tioxide Specialties Ltd	Water-in-oil emulsions

1994
- 1994-09-02 AT AT94927991T patent/ATE383848T1/de active
- 1994-09-02 AU AU77192/94A patent/AU693476B2/en not_active Expired
- 1994-09-02 ES ES94927991T patent/ES2299173T3/es not_active Expired - Lifetime
- 1994-09-02 SG SG1996001710A patent/SG43833A1/en unknown
- 1994-09-02 DE DE69435067T patent/DE69435067T2/de not_active Expired - Lifetime
- 1994-09-02 WO PCT/US1994/009908 patent/WO1995016434A1/en active IP Right Grant
- 1994-09-02 US US08/299,944 patent/US5534554A/en not_active Expired - Lifetime
- 1994-09-02 ES ES04075956T patent/ES2309441T3/es not_active Expired - Lifetime
- 1994-09-02 EP EP94927991A patent/EP0738141B1/de not_active Expired - Lifetime
- 1994-09-02 CA CA002156063A patent/CA2156063C/en not_active Expired - Lifetime
- 1994-09-02 EP EP04075956A patent/EP1473031B1/de not_active Expired - Lifetime
- 1994-09-02 DK DK94927991T patent/DK0738141T3/da active
- 1994-09-02 JP JP51673895A patent/JP4149511B2/ja not_active Expired - Lifetime
- 1994-09-02 DK DK04075956T patent/DK1473031T3/da active
- 1994-09-02 PT PT04075956T patent/PT1473031E/pt unknown
- 1994-09-02 DE DE69435106T patent/DE69435106D1/de not_active Expired - Lifetime
- 1994-09-02 CN CN94194951A patent/CN1103586C/zh not_active Expired - Lifetime
- 1994-09-02 AT AT04075956T patent/ATE399004T1/de active
- 1994-09-02 PT PT94927991T patent/PT738141E/pt unknown
1996
- 1996-06-12 KR KR1019960703083A patent/KR100322507B1/ko not_active IP Right Cessation
2002
- 2002-06-17 CN CNB021233632A patent/CN1223342C/zh not_active Expired - Lifetime
2003
- 2003-11-17 HK HK03108374A patent/HK1056116A1/xx not_active IP Right Cessation
2006
- 2006-05-02 JP JP2006128264A patent/JP2006206610A/ja active Pending

Also Published As

Publication number	Publication date
CA2156063C (en)	1999-06-29
US5534554A (en)	1996-07-09
DK0738141T3 (da)	2008-05-19
WO1995016434A1 (en)	1995-06-22
ATE383848T1 (de)	2008-02-15
ATE399004T1 (de)	2008-07-15
CN1142764A (zh)	1997-02-12
ES2309441T3 (es)	2008-12-16
AU693476B2 (en)	1998-07-02
EP0738141A4 (de)	1998-01-07
SG43833A1 (en)	1997-11-14
JPH09506612A (ja)	1997-06-30
EP0738141B1 (de)	2008-01-16
JP2006206610A (ja)	2006-08-10
JP4149511B2 (ja)	2008-09-10
DK1473031T3 (da)	2008-10-20
PT738141E (pt)	2008-02-11
EP1473031A1 (de)	2004-11-03
PT1473031E (pt)	2008-08-05
AU7719294A (en)	1995-07-03
KR100322507B1 (ko)	2002-08-14
CA2156063A1 (en)	1995-06-22
EP1473031B1 (de)	2008-06-25
CN1103586C (zh)	2003-03-26
ES2299173T3 (es)	2008-05-16
CN1419911A (zh)	2003-05-28
CN1223342C (zh)	2005-10-19
DE69435067D1 (de)	2008-03-06
DE69435067T2 (de)	2008-05-15
EP0738141A1 (de)	1996-10-23
DE69435106D1 (de)	2008-08-07

Publication	Publication Date	Title
HK1056116A1 (en)	2004-02-06	Sucrose ester c-20 to c-28 alcohol formulation
DE68921688D1 (de)	1995-04-20	Wenig reizendes Reinigungsmittel.
HU9302462D0 (en)	1993-11-29	Pesticidal preparatives containing fluorine-alkenyl compounds
FI891552A0 (fi)	1989-03-31	Anti-inflammatorisk emulsionssalvakomposition.
AU626749B2 (en)	1992-08-06	Transparent cosmetic composition containing glycerol, soap, and soap crystal growth inhibitor
SE8404019L (sv)	1985-02-11	Oftalmiska antiinflammatoriska medel
ATE42316T1 (de)	1989-05-15	Phosphorsaeureesterverbindung.
ATE150075T1 (de)	1997-03-15	Detergenzusammensetzung
NO162420C (no)	1989-12-27	Fettsyreestere og kosmetisk preparat inneholdende disse.
DK0556424T3 (da)	1999-01-25	Fremgangsmåde til affarvning af fedtsyreester, samt levnedsmiddel og kosmetisk præparat med en sådan affarvet ester
IT1186748B (it)	1987-12-16	Procedimento per la formazione di composizioni omogenee di carburanti contenenti una frazione di petrolio ed almeno un alcol alifatico a catena corta e composizioni omogenee cosi' ottenute
GB8809027D0 (en)	1988-05-18	Carbonylation of allylic alcohols
AU4061185A (en)	1985-08-27	Salicylic acid ester perfume compositions
DK0407815T3 (da)	1993-06-01	Præparat indeholdende polyprenylforbindelser til bløde kapsler
JPS5427523A (en)	1979-03-01	Preparation of hydroxy fatty acid ester
ES2069765T3 (es)	1995-05-16	Nuevos derivados del acido 2,2-dimetil-ciclopropenocarboxilico que llevan en posicion 3 una cadena halogenada saturada, su procedimiento de preparacion y su aplicacion en la sintesis de productos plaguicidas.
JPS57154192A (en)	1982-09-22	Bis-esters of alkanediol as antibacterial
FI885708A0 (fi)	1988-12-09	Foerfarande foer metylering av xantiner.
JPS5441385A (en)	1979-04-02	Ester synthesis of terpene alcohol by lypase
DE3864509D1 (de)	1991-10-02	Alkoventrennung.
JPS5414924A (en)	1979-02-03	Preparation of (-)-cis-1,2-epoxypropylphosphonic acid derivative
JPS543040A (en)	1979-01-11	Preparation of bisabolene
IT1223169B (it)	1990-09-12	Procedimento per la preparazione di monoeteri di idrochinoni
KR900015583U (ko)	1990-09-01	경운기의 조작레버구조
JPS53135917A (en)	1978-11-28	Preparation of 3,3-dimethyl-1-hexen-5-one

Legal Events

Date	Code	Title	Description
2014-10-03	PE	Patent expired	Effective date: 20140901