HK1052506B - 化合物 - Google Patents

化合物

Info

Publication number: HK1052506B
Authority: HK; Hong Kong
Prior art keywords: chemical compounds; compounds; chemical
Prior art date: 1999-10-07

Application number

HK03104740.2A

Other languages

English (en)

Other versions

HK1052506A1 (en

Inventor

朱塞普‧阿爾瓦諾

羅馬諾‧迪法比奧

里卡多‧喬萬尼尼

朱塞普‧格西奧

伊維斯‧聖丹尼斯

安托內拉‧厄西尼

Original Assignee

葛蘭素集團有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-07

Filing date

2003-07-03

Publication date

2008-12-19

2003-07-03 Application filed by 葛蘭素集團有限公司 filed Critical 葛蘭素集團有限公司

2003-09-19 Publication of HK1052506A1 publication Critical patent/HK1052506A1/xx

2008-12-19 Publication of HK1052506B publication Critical patent/HK1052506B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

HK03104740.2A 1999-10-07 2003-07-03 化合物 HK1052506B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9923748.9A GB9923748D0 (en)	1999-10-07	1999-10-07	Chemical compounds
PCT/EP2000/009722 WO2001025219A2 (en)	1999-10-07	2000-10-05	Piperazine compounds

Publications (2)

Publication Number	Publication Date
HK1052506A1 HK1052506A1 (en)	2003-09-19
HK1052506B true HK1052506B (zh)	2008-12-19

Family

ID=10862304

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
HK03104740.2A HK1052506B (zh)	1999-10-07	2003-07-03	化合物
HK04108748A HK1065798A1 (en)	1999-10-07	2004-11-06	Pharmaceutical compositions comprising tachykininsantagonists and a serotonin reuptake inhibitor
HK04109454.6A HK1066537A1 (en)	1999-10-07	2004-12-01	Piperazine compounds as tachykinins inhibitors

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
HK04108748A HK1065798A1 (en)	1999-10-07	2004-11-06	Pharmaceutical compositions comprising tachykininsantagonists and a serotonin reuptake inhibitor
HK04109454.6A HK1066537A1 (en)	1999-10-07	2004-12-01	Piperazine compounds as tachykinins inhibitors

Country Status (33)

Country	Link
US (6)	US6951861B1 (zh)
EP (3)	EP1460066B1 (zh)
JP (1)	JP4776844B2 (zh)
KR (2)	KR100857671B1 (zh)
CN (1)	CN100413850C (zh)
AR (2)	AR025975A1 (zh)
AT (3)	ATE407125T1 (zh)
AU (1)	AU768780B2 (zh)
BR (1)	BR0014541A (zh)
CA (1)	CA2386515C (zh)
CO (1)	CO5251467A1 (zh)
CY (2)	CY1110172T1 (zh)
CZ (1)	CZ302340B6 (zh)
DE (3)	DE60012031T2 (zh)
DK (3)	DK1218359T3 (zh)
ES (3)	ES2329130T3 (zh)
GB (1)	GB9923748D0 (zh)
HK (3)	HK1052506B (zh)
HU (1)	HUP0203136A3 (zh)
IL (2)	IL148964A0 (zh)
MX (1)	MXPA02003515A (zh)
MY (1)	MY130907A (zh)
NO (1)	NO323776B1 (zh)
NZ (2)	NZ531127A (zh)
PE (1)	PE20010741A1 (zh)
PL (1)	PL201191B1 (zh)
PT (3)	PT1454901E (zh)
SI (3)	SI1454901T1 (zh)
TN (1)	TNSN00194A1 (zh)
TR (1)	TR200200936T2 (zh)
TW (1)	TWI225485B (zh)
WO (1)	WO2001025219A2 (zh)
ZA (1)	ZA200202589B (zh)

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JP4904945B2 (ja)	2006-06-30	2012-03-28	セントラル硝子株式会社	光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体の製造方法
GB0621229D0 (en) *	2006-10-20	2006-12-06	Glaxo Group Ltd	Novel use
US8093268B2 (en)	2007-01-24	2012-01-10	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
JP5510040B2 (ja) *	2010-04-28	2014-06-04	セントラル硝子株式会社	光学活性（ｒ）−１−（４−フルオロフェニル）エチルアミンを得る光学分割
WO2012175434A1 (en)	2011-06-20	2012-12-27	Glaxo Group Limited	Pharmaceutical formulations comprising vestipitant
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1999
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2000
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Also Published As

Publication number	Publication date
KR20020038800A (ko)	2002-05-23
EP1454901B1 (en)	2008-09-03
CA2386515A1 (en)	2001-04-12
BR0014541A (pt)	2002-09-17
TNSN00194A1 (en)	2005-11-10
AR025975A1 (es)	2002-12-26
IL148964A (en)	2007-02-11
ES2329130T3 (es)	2009-11-23
PL356261A1 (en)	2004-06-28
PT1454901E (pt)	2008-12-12
DE60042501D1 (de)	2009-08-13
US7345041B2 (en)	2008-03-18
CN1391564A (zh)	2003-01-15
US7071196B2 (en)	2006-07-04
ZA200202589B (en)	2003-08-27
PL201191B1 (pl)	2009-03-31
JP2003511377A (ja)	2003-03-25
HK1065798A1 (en)	2005-03-04
ATE270664T1 (de)	2004-07-15
CN100413850C (zh)	2008-08-27
ATE407125T1 (de)	2008-09-15
CZ302340B6 (cs)	2011-03-23
EP1454901A1 (en)	2004-09-08
DE60040176D1 (de)	2008-10-16
ES2312917T3 (es)	2009-03-01
PE20010741A1 (es)	2001-07-18
TWI225485B (en)	2004-12-21
MXPA02003515A (es)	2002-09-02
DK1454901T3 (da)	2009-01-12
US20060122192A1 (en)	2006-06-08
KR100817373B1 (ko)	2008-03-27
HK1066537A1 (en)	2005-03-24
EP1218359B1 (en)	2004-07-07
NZ518144A (en)	2004-04-30
WO2001025219A3 (en)	2001-12-13
US20040209893A1 (en)	2004-10-21
EP1460066B1 (en)	2009-07-01
NO20021637D0 (no)	2002-04-05
SI1218359T1 (en)	2005-02-28
SI1460066T1 (sl)	2009-12-31
ES2222927T3 (es)	2005-02-16
NO20021637L (no)	2002-06-06
KR20070112308A (ko)	2007-11-22
IL148964A0 (en)	2002-11-10
PT1218359E (pt)	2004-10-29
AR077414A2 (es)	2011-08-24
ATE435215T1 (de)	2009-07-15
DK1218359T3 (da)	2004-10-18
KR100857671B1 (ko)	2008-09-08
EP1218359A2 (en)	2002-07-03
MY130907A (en)	2007-07-31
AU7913900A (en)	2001-05-10
CZ20021166A3 (cs)	2002-11-13
DK1460066T3 (da)	2009-11-02
JP4776844B2 (ja)	2011-09-21
US7625904B2 (en)	2009-12-01
CY1110172T1 (el)	2015-01-14
CA2386515C (en)	2011-06-07
TR200200936T2 (tr)	2002-07-22
NO323776B1 (no)	2007-07-02
SI1454901T1 (sl)	2009-02-28
US20080249108A1 (en)	2008-10-09
US6642240B2 (en)	2003-11-04
HK1052506A1 (en)	2003-09-19
US20030028021A1 (en)	2003-02-06
HUP0203136A3 (en)	2003-03-28
CO5251467A1 (es)	2003-02-28
DE60012031T2 (de)	2005-07-07
US20040048862A1 (en)	2004-03-11
EP1460066A1 (en)	2004-09-22
GB9923748D0 (en)	1999-12-08
PT1460066E (pt)	2009-09-10
WO2001025219A2 (en)	2001-04-12
CY1110104T1 (el)	2015-01-14
HUP0203136A2 (hu)	2003-02-28
AU768780B2 (en)	2004-01-08
DE60012031D1 (de)	2004-08-12
NZ531127A (en)	2005-11-25
US6951861B1 (en)	2005-10-04

Publication	Publication Date	Title
GB9907658D0 (en)	1999-05-26	Chemical compounds
GB9902461D0 (en)	1999-03-24	Chemical compounds
GB9923748D0 (en)	1999-12-08	Chemical compounds
GB9909409D0 (en)	1999-06-23	Chemical compounds
GB9910104D0 (en)	1999-06-30	Chemical compounds
GB9910110D0 (en)	1999-06-30	Chemical compounds
GB9914025D0 (en)	1999-08-18	Chemical compounds
GB9900078D0 (en)	1999-02-24	Chemical compounds
GB9914024D0 (en)	1999-08-18	Chemical compounds
GB9910394D0 (en)	1999-07-07	Chemical compounds
GB9914015D0 (en)	1999-08-18	Chemical compounds
GB9914022D0 (en)	1999-08-18	Chemical compounds
GB9910419D0 (en)	1999-07-07	Chemical compounds
GB9908355D0 (en)	1999-06-09	Chemical compounds
GB9909582D0 (en)	1999-06-23	Chemical compounds
GB9912640D0 (en)	1999-07-28	Chemical compounds
GB9909668D0 (en)	1999-06-23	Chemical compounds
GB9907657D0 (en)	1999-05-26	Chemical compounds
GB9903860D0 (en)	1999-04-14	Chemical compounds
GB9909062D0 (en)	1999-06-16	Chemical compounds
GB9901795D0 (en)	1999-03-17	Chemical compounds
GB9909408D0 (en)	1999-06-23	Chemical compounds
GB9910396D0 (en)	1999-07-07	Chemical compounds
GB0001663D0 (en)	2000-03-15	Chemical compounds
GB9906565D0 (en)	1999-05-19	Chemical compounds

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2019-05-17	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20181005