[go: up one dir, main page]

HK1025954A1 - Triptolide derivatives useful in the treatment of autoimmune diseases - Google Patents

Triptolide derivatives useful in the treatment of autoimmune diseases

Info

Publication number
HK1025954A1
HK1025954A1 HK00105090A HK00105090A HK1025954A1 HK 1025954 A1 HK1025954 A1 HK 1025954A1 HK 00105090 A HK00105090 A HK 00105090A HK 00105090 A HK00105090 A HK 00105090A HK 1025954 A1 HK1025954 A1 HK 1025954A1
Authority
HK
Hong Kong
Prior art keywords
treatment
autoimmune diseases
derivatives useful
triptolide derivatives
triptolide
Prior art date
Application number
HK00105090A
Other languages
English (en)
Inventor
Michel J Jung
Mahinda Wickramaratne
Michael Hepperle
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of HK1025954A1 publication Critical patent/HK1025954A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK00105090A 1997-05-23 2000-08-15 Triptolide derivatives useful in the treatment of autoimmune diseases HK1025954A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86248997A 1997-05-23 1997-05-23
PCT/US1998/008562 WO1998052933A1 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
HK1025954A1 true HK1025954A1 (en) 2000-12-01

Family

ID=25338618

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00105090A HK1025954A1 (en) 1997-05-23 2000-08-15 Triptolide derivatives useful in the treatment of autoimmune diseases

Country Status (18)

Country Link
EP (1) EP0983256B1 (es)
JP (1) JP2002500647A (es)
KR (1) KR20010012820A (es)
AR (1) AR012737A1 (es)
AT (1) ATE261434T1 (es)
AU (1) AU741209B2 (es)
BR (1) BR9809673A (es)
CA (1) CA2288327A1 (es)
DE (1) DE69822297T2 (es)
ES (1) ES2213279T3 (es)
HK (1) HK1025954A1 (es)
HU (1) HUP0003244A3 (es)
IL (1) IL133089A0 (es)
NO (1) NO995722L (es)
NZ (1) NZ500699A (es)
TW (1) TW462966B (es)
WO (1) WO1998052933A1 (es)
ZA (1) ZA984177B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1390358A4 (en) * 2001-03-15 2004-06-16 Pharmagenesis Inc AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
WO2005077008A2 (en) 2004-02-09 2005-08-25 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from tripterygium wilfordii
JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス， インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
WO2010113096A1 (en) 2009-03-30 2010-10-07 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
CN103533934B (zh) 2011-03-17 2016-03-30 特尔汗什莫尔医学基础设施研究和服务公司 用于治疗自身免疫性疾病的喹诺酮类似物
CA2925698C (en) 2013-11-28 2021-11-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
CN113768939A (zh) * 2021-09-30 2021-12-10 深圳艾克斯恩生物科技有限公司 雷公藤二醇在制备预防和/或治疗nlrp3炎症小体介导的炎症性疾病药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026265A1 (en) * 1993-05-06 1994-11-24 Pharmagenesis, Inc. 16-hydroxytriptolide composition and method for immunotherapy
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
CA2288327A1 (en) 1998-11-26
KR20010012820A (ko) 2001-02-26
DE69822297D1 (de) 2004-04-15
NO995722L (no) 2000-01-21
HUP0003244A3 (en) 2001-09-28
EP0983256A1 (en) 2000-03-08
ATE261434T1 (de) 2004-03-15
ES2213279T3 (es) 2004-08-16
AU7363498A (en) 1998-12-11
HUP0003244A2 (en) 2001-03-28
AR012737A1 (es) 2000-11-08
BR9809673A (pt) 2000-07-11
TW462966B (en) 2001-11-11
DE69822297T2 (de) 2004-07-29
AU741209B2 (en) 2001-11-22
WO1998052933A1 (en) 1998-11-26
JP2002500647A (ja) 2002-01-08
IL133089A0 (en) 2001-03-19
ZA984177B (en) 1998-11-23
NO995722D0 (no) 1999-11-22
EP0983256B1 (en) 2004-03-10
NZ500699A (en) 2001-08-31

Similar Documents

Publication Publication Date Title
ZA983452B (en) Substituted pyrrolopyridines useful in the treatment of inflammatory diseases.
IL132318A0 (en) Substituted imidazoles useful in the treatment of inflammatory diseases
IL142908A0 (en) Compounds useful in the treatment of inflammatory diseases
GB9701206D0 (en) Serine derivatives and their use as therapeutic agents
ZA9710339B (en) Xanthines and their therapeutic use
AP9701029A0 (en) Indole derivatives useful in the treatment of osteoporosis
HUP0102142A3 (en) Use of cyclosporins in the treatment of inflammatory autoimmune diseases
HK1026096A1 (en) Novel triptolide derivatives useful in the treatment of autoimmune diseases
HK1025954A1 (en) Triptolide derivatives useful in the treatment of autoimmune diseases
PL336579A1 (en) Treatment of diseases associated with cytokinins
EP0797440A4 (en) TREATING AUTOIMMUNE DISEASES WITH THE AID OF 2-AMINOPURINE DERIVATIVES
IL129460A0 (en) Use of lofexidine in the treatment of behavioral disorders
GB9620777D0 (en) Therapeutic use
SI0983275T1 (en) Novel triptolide derivatives useful in the treatment of autoimmune diseases
GB9726223D0 (en) The treatment of materials
GB9609944D0 (en) An improvement in the treatment of wastes
AU8760298A (en) Coup-tfi directed therapies in the treatment of disease
HUP9800272A3 (en) Use of penciclovir for the treatment of human herpes-virus-8
EP0872219A4 (en) APPLICATION OF THE BIOFREQUENCY SPECT IN EMBYOTHECHNOLOGY IN ANIMALS
GB2286716B (en) The treatment of solid wastes
ZA984822B (en) Pyrrolo (2,11,5-cd) indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA984823B (en) Pyrrolo(2,1,5-cd)indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA953839B (en) The administration of magnesium
AUPO922297A0 (en) Disulphide useful in the treatment of cardiovascular diseases
GB9707104D0 (en) An improvement in the treatment of bio-waste

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120427