HK1010050A1 - The sulphate salt of a substituted triazole pharmaceutical compositions thereof and their use in therapy - Google Patents

The sulphate salt of a substituted triazole pharmaceutical compositions thereof and their use in therapy

Info

Publication number: HK1010050A1
Authority: HK; Hong Kong
Prior art keywords: therapy; pharmaceutical compositions; sulphate salt; substituted triazole; receptors
Prior art date: 1992-06-05

Application number

HK98110478A

Other languages

English (en)

Inventor

Raymond Baker

Kendal G Pitt

Victor G Matassa

Carole Olive

David E Storey

Leslie J Street

Alexander Richard Guiblin

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-05

Filing date

1998-09-05

Publication date

1999-06-11

1992-06-05 Priority claimed from GB929211903A external-priority patent/GB9211903D0/en

1993-04-07 Priority claimed from GB939307306A external-priority patent/GB9307306D0/en

1998-09-05 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1999-06-11 Publication of HK1010050A1 publication Critical patent/HK1010050A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

HK98110478A 1992-06-05 1998-09-05 The sulphate salt of a substituted triazole pharmaceutical compositions thereof and their use in therapy HK1010050A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929211903A GB9211903D0 (en)	1992-06-05	1992-06-05	Pharmaceutical composition
GB939307306A GB9307306D0 (en)	1993-04-07	1993-04-07	Therapeutic agents

Publications (1)

Publication Number	Publication Date
HK1010050A1 true HK1010050A1 (en)	1999-06-11

Family

ID=26301005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98110478A HK1010050A1 (en)	1992-06-05	1998-09-05	The sulphate salt of a substituted triazole pharmaceutical compositions thereof and their use in therapy

Country Status (27)

Country	Link
US (1)	US5527817A (sk)
EP (1)	EP0573221B1 (sk)
JP (2)	JP2619197B2 (sk)
KR (1)	KR100286411B1 (sk)
CN (1)	CN1043532C (sk)
AT (1)	ATE165602T1 (sk)
AU (2)	AU659311B2 (sk)
BG (1)	BG61976B1 (sk)
CA (1)	CA2097208C (sk)
CZ (1)	CZ282060B6 (sk)
DE (1)	DE69318212T2 (sk)
DK (1)	DK0573221T3 (sk)
ES (1)	ES2116411T3 (sk)
FI (3)	FI106201B (sk)
HK (1)	HK1010050A1 (sk)
HU (1)	HUT71403A (sk)
IL (1)	IL105847A (sk)
LV (1)	LV12210B (sk)
MX (1)	MX9303373A (sk)
NO (1)	NO307420B1 (sk)
NZ (1)	NZ253210A (sk)
RO (1)	RO114326B1 (sk)
RU (1)	RU2130022C1 (sk)
SG (1)	SG50406A1 (sk)
SK (1)	SK279211B6 (sk)
UA (1)	UA27908C2 (sk)
WO (1)	WO1993025547A1 (sk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA965837B (en) *	1995-07-11	1997-01-31	Merck & Co Inc	A triazolylmethyl-indole ethylamine bisulfate salt
ATE207485T1 (de) *	1995-07-11	2001-11-15	Merck & Co Inc	Ein triazolylmethyl-indol-ethylamin-bisulfat-salz
US6349719B2 (en)	1997-02-24	2002-02-26	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6192882B1 (en) *	1997-02-24	2001-02-27	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
DE69922688T2 (de)	1998-11-02	2005-12-01	Merck & Co. Inc.	Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne
CN100439360C (zh)	2001-08-15	2008-12-03	法玛西雅厄普约翰美国公司	包括n-[2-(二乙氨基)乙基]-5-[(5-氟-2-氧代-3h-吲哚-3-亚基)甲基]-2,4-二甲基-1h-吡咯-3-甲酰胺的苹果酸盐的晶体、其制备方法和其组合物
WO2006137083A1 (en) *	2005-06-20	2006-12-28	Natco Pharma Limited	Improved process for the preparation of rizatriptan benzoate
ES2270717B1 (es) *	2005-08-08	2008-03-01	Ragactives, S.L.	Procedimiento para la obtencion de derivados de triptamina.
US20090062550A1 (en) *	2005-11-14	2009-03-05	Matrix Laboratories Ltd	Process for the Large Scale Production of Rizatriptan Benzoate
AU2008259518A1 (en) *	2007-06-04	2008-12-11	Generics [Uk] Limited	Novel process
CA3010568C (en)	2016-01-27	2023-10-17	Instar Technologies A.S.	Oromucosal nanofiber carriers for therapeutic treatment
WO2024144413A1 (ru) *	2022-12-28	2024-07-04	Общество С Ограниченной Ответственностью "Ферринг Продакшн"	Жидкая фармацевтическая композиция для назального введения, содержащая ризатриптан

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB9026998D0 (en) *	1990-12-12	1991-01-30	Glaxo Group Ltd	Medicaments
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi

1993
- 1993-05-28 EP EP93304158A patent/EP0573221B1/en not_active Expired - Lifetime
- 1993-05-28 JP JP5127463A patent/JP2619197B2/ja not_active Expired - Fee Related
- 1993-05-28 HU HU9403478A patent/HUT71403A/hu unknown
- 1993-05-28 RO RO94-01910A patent/RO114326B1/ro unknown
- 1993-05-28 RU RU94046380/04A patent/RU2130022C1/ru not_active IP Right Cessation
- 1993-05-28 AT AT93304158T patent/ATE165602T1/de not_active IP Right Cessation
- 1993-05-28 WO PCT/GB1993/001132 patent/WO1993025547A1/en active IP Right Grant
- 1993-05-28 CA CA002097208A patent/CA2097208C/en not_active Expired - Fee Related
- 1993-05-28 DE DE69318212T patent/DE69318212T2/de not_active Expired - Fee Related
- 1993-05-28 NZ NZ253210A patent/NZ253210A/en unknown
- 1993-05-28 AU AU39875/93A patent/AU659311B2/en not_active Ceased
- 1993-05-28 AU AU43372/93A patent/AU4337293A/en not_active Abandoned
- 1993-05-28 KR KR1019940704402A patent/KR100286411B1/ko not_active Expired - Fee Related
- 1993-05-28 SG SG1996000374A patent/SG50406A1/en unknown
- 1993-05-28 DK DK93304158T patent/DK0573221T3/da active
- 1993-05-28 ES ES93304158T patent/ES2116411T3/es not_active Expired - Lifetime
- 1993-05-28 SK SK1479-94A patent/SK279211B6/sk unknown
- 1993-05-28 UA UA94129126A patent/UA27908C2/uk unknown
- 1993-05-28 CZ CZ943044A patent/CZ282060B6/cs not_active IP Right Cessation
- 1993-05-31 IL IL10584793A patent/IL105847A/en not_active IP Right Cessation
- 1993-06-04 MX MX9303373A patent/MX9303373A/es not_active IP Right Cessation
- 1993-06-05 CN CN93108728A patent/CN1043532C/zh not_active Expired - Fee Related
1994
- 1994-10-21 BG BG99132A patent/BG61976B1/bg unknown
- 1994-12-02 FI FI945694A patent/FI106201B/fi active
- 1994-12-02 NO NO944656A patent/NO307420B1/no not_active IP Right Cessation
- 1994-12-07 US US08/350,760 patent/US5527817A/en not_active Expired - Lifetime
1996
- 1996-08-30 JP JP8230809A patent/JP2972150B2/ja not_active Expired - Fee Related
1998
- 1998-09-05 HK HK98110478A patent/HK1010050A1/xx not_active IP Right Cessation
- 1998-10-26 LV LVP-98-237A patent/LV12210B/en unknown
2000
- 2000-08-10 FI FI20001777A patent/FI20001777L/fi unknown
- 2000-08-10 FI FI20001776A patent/FI20001776L/fi unknown

Also Published As

Publication number	Publication date
BG99132A (bg)	1995-07-28
SG50406A1 (en)	1998-07-20
MX9303373A (es)	1995-01-31
JPH0641121A (ja)	1994-02-15
EP0573221B1 (en)	1998-04-29
CZ304494A3 (en)	1995-09-13
CN1043532C (zh)	1999-06-02
IL105847A0 (en)	1993-09-22
FI20001777L (fi)	2000-08-10
EP0573221A1 (en)	1993-12-08
KR100286411B1 (ko)	2001-04-16
AU659311B2 (en)	1995-05-11
FI20001776L (fi)	2000-08-10
ES2116411T3 (es)	1998-07-16
KR950701922A (ko)	1995-05-17
NO944656L (no)	1994-12-02
HUT71403A (en)	1995-11-28
AU3987593A (en)	1993-12-09
RU94046380A (ru)	1996-12-10
AU4337293A (en)	1994-01-04
UA27908C2 (uk)	2000-10-16
JPH09176155A (ja)	1997-07-08
FI945694L (fi)	1994-12-02
NZ253210A (en)	1995-09-26
DK0573221T3 (da)	1998-10-07
CZ282060B6 (cs)	1997-05-14
WO1993025547A1 (en)	1993-12-23
SK279211B6 (sk)	1998-08-05
NO307420B1 (no)	2000-04-03
NO944656D0 (no)	1994-12-02
JP2972150B2 (ja)	1999-11-08
CN1089263A (zh)	1994-07-13
FI945694A0 (fi)	1994-12-02
RU2130022C1 (ru)	1999-05-10
LV12210A (lv)	1999-01-20
JP2619197B2 (ja)	1997-06-11
RO114326B1 (ro)	1999-03-30
DE69318212D1 (de)	1998-06-04
CA2097208A1 (en)	1993-12-06
HU9403478D0 (en)	1995-02-28
CA2097208C (en)	2005-02-08
FI106201B (fi)	2000-12-15
IL105847A (en)	1998-09-24
LV12210B (en)	1999-03-20
ATE165602T1 (de)	1998-05-15
SK147994A3 (en)	1995-07-11
BG61976B1 (bg)	1998-11-30
DE69318212T2 (de)	1998-11-19
US5527817A (en)	1996-06-18

Publication	Publication Date	Title
IL96891A0 (en)	1992-03-29	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
HUT71403A (en)	1995-11-28	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
AU1687592A (en)	1992-10-21	5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
AU4215593A (en)	1994-02-03	4-substituted 1,2,4-triazole derivatives
HUT61438A (en)	1993-01-28	Synergetic fungicidal composition
HUP9802677A3 (en)	1999-11-29	Use of 1,2,4-triazole derivatives for the manufacture of a medicament for the treatment of cancers
IL84844A0 (en)	1988-06-30	Pharmaceutical compositions comprising a certain carbazolone derivative or a salt thereof
WO1993023035A3 (en)	1994-03-03	Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease
CA2135709A1 (en)	1995-05-19	Melatonin derivatives for use in treating sleep disorders
ZA962715B (en)	1997-10-06	Pharmaceutical agents for the treatment of Alzheimer's disease.
CA2135710A1 (en)	1995-05-19	Melatonin derivatives for use in treating desynchronization disorders
GB9207396D0 (en)	1992-05-13	Therapeutic agents
MY110795A (en)	1999-04-30	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
ITRM940322A0 (it)	1994-05-24	"composizione farmaceutica contenente carbazolone per il trattamento di emicrania e disturbi psicotici e relativo metodo di preparazione edapplicazione".
EP0367069A3 (de)	1991-06-26	Substituierte Bisazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UA29461C2 (uk)	2000-11-15	Засіб для лікування амілоїдозу, спосіб лікування амілоїдозу
AU6542896A (en)	1997-02-10	A triazolylmethyl-indole ethylamine bisulfate salt
DE3473447D1 (en)	1988-09-22	Triazole antifungal agents
MY108739A (en)	1996-11-30	Imidazole, triazole and tetrazole derivatives

Legal Events

Date	Code	Title	Description
2004-12-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)