HK1010050A1 - The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy - Google Patents

The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy Download PDF

Info

Publication number: HK1010050A1
Authority: HK; Hong Kong
Prior art keywords: salt; pharmaceutically acceptable; composition; formula; solvate
Prior art date: 1992-06-05

Application number

HK98110478A

Other languages

German (de)

English (en)

French (fr)

Chinese (zh)

Other versions

HK1010050B (en

Inventor

Baker Raymond

G. Pitt Kendal

G. Matassa Victor

Olive Carole

E. Storey David

J. Street Leslie

Richard Guiblin Alexander

Original Assignee

Merck Sharp & Dohme Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-05

Filing date

1998-09-05

Publication date

1999-06-11

1992-06-05 Priority claimed from GB929211903A external-priority patent/GB9211903D0/en

1993-04-07 Priority claimed from GB939307306A external-priority patent/GB9307306D0/en

1998-09-05 Application filed by Merck Sharp & Dohme Ltd. filed Critical Merck Sharp & Dohme Ltd.

1999-06-11 Publication of HK1010050B publication Critical patent/HK1010050B/en

1999-06-11 Publication of HK1010050A1 publication Critical patent/HK1010050A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

HK98110478A 1992-06-05 1998-09-05 The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy HK1010050A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9211903		1992-06-05
GB929211903A GB9211903D0 (en)	1992-06-05	1992-06-05	Pharmaceutical composition
GB939307306A GB9307306D0 (en)	1993-04-07	1993-04-07	Therapeutic agents
GB9307306		1993-04-07

Publications (2)

Publication Number	Publication Date
HK1010050B HK1010050B (en)	1999-06-11
HK1010050A1 true HK1010050A1 (en)	1999-06-11

Family

ID=26301005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98110478A HK1010050A1 (en)	1992-06-05	1998-09-05	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy

Country Status (27)

Country	Link
US (1)	US5527817A (fi)
EP (1)	EP0573221B1 (fi)
JP (2)	JP2619197B2 (fi)
KR (1)	KR100286411B1 (fi)
CN (1)	CN1043532C (fi)
AT (1)	ATE165602T1 (fi)
AU (2)	AU659311B2 (fi)
BG (1)	BG61976B1 (fi)
CA (1)	CA2097208C (fi)
CZ (1)	CZ282060B6 (fi)
DE (1)	DE69318212T2 (fi)
DK (1)	DK0573221T3 (fi)
ES (1)	ES2116411T3 (fi)
FI (3)	FI106201B (fi)
HK (1)	HK1010050A1 (fi)
HU (1)	HUT71403A (fi)
IL (1)	IL105847A (fi)
LV (1)	LV12210B (fi)
MX (1)	MX9303373A (fi)
NO (1)	NO307420B1 (fi)
NZ (1)	NZ253210A (fi)
RO (1)	RO114326B1 (fi)
RU (1)	RU2130022C1 (fi)
SG (1)	SG50406A1 (fi)
SK (1)	SK279211B6 (fi)
UA (1)	UA27908C2 (fi)
WO (1)	WO1993025547A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ282060B6 (cs) *	1992-06-05	1997-05-14	Merck Sharp And Dohme Limited	Sulfátová sůl substituovaného triazolu, způsob její výroby, farmaceutický prostředek s jejím obsahem a způsob jeho výroby
ZA965837B (en) *	1995-07-11	1997-01-31	Merck & Co Inc	A triazolylmethyl-indole ethylamine bisulfate salt
WO1997003068A1 (en) *	1995-07-11	1997-01-30	Merck & Co., Inc.	A triazolylmethyl-indole ethylamine bisulfate salt
US6192882B1 (en) *	1997-02-24	2001-02-27	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6349719B2 (en)	1997-02-24	2002-02-26	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
JP2002528498A (ja) *	1998-11-02	2002-09-03	メルクエンドカムパニーインコーポレーテッド	片頭痛の治療方法及び医薬組成物
EP2332934B1 (en)	2001-08-15	2017-03-01	Pharmacia & Upjohn Company LLC	Processes for the preparation of crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide.
WO2006137083A1 (en) *	2005-06-20	2006-12-28	Natco Pharma Limited	Improved process for the preparation of rizatriptan benzoate
ES2270717B1 (es) *	2005-08-08	2008-03-01	Ragactives, S.L.	Procedimiento para la obtencion de derivados de triptamina.
WO2007054979A1 (en) *	2005-11-14	2007-05-18	Matrix Laboratories Ltd	Process for the large scale production of rizatriptan benzoate
CA2688463A1 (en) *	2007-06-04	2008-12-11	Generics [Uk] Limited	Process for the preparation of rizatriptan
WO2017130141A1 (en)	2016-01-27	2017-08-03	Instar Technologies A.S.	Oromucosal nanofiber carriers for therapeutic treatment
WO2024144413A1 (ru) *	2022-12-28	2024-07-04	Общество С Ограниченной Ответственностью "Ферринг Продакшн"	Жидкая фармацевтическая композиция для назального введения, содержащая ризатриптан

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1528319A3 (ru) *	1985-07-23	1989-12-07	Глэксо Груп Лимитед (Фирма)	Способ получени производных имидазола или их физиологически приемлемых солей
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
KR920011020B1 (ko) *	1989-07-03	1992-12-26	요시또미세이야꾸 가부시끼가이샤	벤즈아진 화합물 및 그의 의약용도
US5075313A (en) *	1990-09-13	1991-12-24	Eli Lilly And Company	3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof
GB9026998D0 (en) *	1990-12-12	1991-01-30	Glaxo Group Ltd	Medicaments
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
CZ282060B6 (cs) *	1992-06-05	1997-05-14	Merck Sharp And Dohme Limited	Sulfátová sůl substituovaného triazolu, způsob její výroby, farmaceutický prostředek s jejím obsahem a způsob jeho výroby

1993
- 1993-05-28 CZ CZ943044A patent/CZ282060B6/cs not_active IP Right Cessation
- 1993-05-28 AU AU39875/93A patent/AU659311B2/en not_active Ceased
- 1993-05-28 KR KR1019940704402A patent/KR100286411B1/ko not_active Expired - Fee Related
- 1993-05-28 SK SK1479-94A patent/SK279211B6/sk unknown
- 1993-05-28 ES ES93304158T patent/ES2116411T3/es not_active Expired - Lifetime
- 1993-05-28 NZ NZ253210A patent/NZ253210A/en unknown
- 1993-05-28 HU HU9403478A patent/HUT71403A/hu unknown
- 1993-05-28 JP JP5127463A patent/JP2619197B2/ja not_active Expired - Fee Related
- 1993-05-28 AT AT93304158T patent/ATE165602T1/de not_active IP Right Cessation
- 1993-05-28 CA CA002097208A patent/CA2097208C/en not_active Expired - Fee Related
- 1993-05-28 UA UA94129126A patent/UA27908C2/uk unknown
- 1993-05-28 RU RU94046380/04A patent/RU2130022C1/ru not_active IP Right Cessation
- 1993-05-28 WO PCT/GB1993/001132 patent/WO1993025547A1/en active IP Right Grant
- 1993-05-28 AU AU43372/93A patent/AU4337293A/en not_active Abandoned
- 1993-05-28 RO RO94-01910A patent/RO114326B1/ro unknown
- 1993-05-28 DE DE69318212T patent/DE69318212T2/de not_active Expired - Fee Related
- 1993-05-28 SG SG1996000374A patent/SG50406A1/en unknown
- 1993-05-28 DK DK93304158T patent/DK0573221T3/da active
- 1993-05-28 EP EP93304158A patent/EP0573221B1/en not_active Expired - Lifetime
- 1993-05-31 IL IL10584793A patent/IL105847A/en not_active IP Right Cessation
- 1993-06-04 MX MX9303373A patent/MX9303373A/es not_active IP Right Cessation
- 1993-06-05 CN CN93108728A patent/CN1043532C/zh not_active Expired - Fee Related
1994
- 1994-10-21 BG BG99132A patent/BG61976B1/bg unknown
- 1994-12-02 NO NO944656A patent/NO307420B1/no not_active IP Right Cessation
- 1994-12-02 FI FI945694A patent/FI106201B/fi active
- 1994-12-07 US US08/350,760 patent/US5527817A/en not_active Expired - Lifetime
1996
- 1996-08-30 JP JP8230809A patent/JP2972150B2/ja not_active Expired - Fee Related
1998
- 1998-09-05 HK HK98110478A patent/HK1010050A1/en not_active IP Right Cessation
- 1998-10-26 LV LVP-98-237A patent/LV12210B/en unknown
2000
- 2000-08-10 FI FI20001777A patent/FI20001777L/fi unknown
- 2000-08-10 FI FI20001776A patent/FI20001776L/fi unknown

Also Published As

Publication number	Publication date
UA27908C2 (uk)	2000-10-16
NO944656D0 (no)	1994-12-02
CZ304494A3 (en)	1995-09-13
RO114326B1 (ro)	1999-03-30
FI20001776A7 (fi)	2000-08-10
US5527817A (en)	1996-06-18
LV12210B (en)	1999-03-20
SK147994A3 (en)	1995-07-11
AU4337293A (en)	1994-01-04
BG99132A (bg)	1995-07-28
JP2972150B2 (ja)	1999-11-08
KR100286411B1 (ko)	2001-04-16
BG61976B1 (bg)	1998-11-30
SG50406A1 (en)	1998-07-20
CN1089263A (zh)	1994-07-13
JPH09176155A (ja)	1997-07-08
RU2130022C1 (ru)	1999-05-10
ES2116411T3 (es)	1998-07-16
FI20001777A7 (fi)	2000-08-10
NZ253210A (en)	1995-09-26
EP0573221B1 (en)	1998-04-29
IL105847A0 (en)	1993-09-22
LV12210A (lv)	1999-01-20
HU9403478D0 (en)	1995-02-28
KR950701922A (ko)	1995-05-17
NO944656L (no)	1994-12-02
DK0573221T3 (da)	1998-10-07
CA2097208A1 (en)	1993-12-06
MX9303373A (es)	1995-01-31
DE69318212D1 (de)	1998-06-04
AU3987593A (en)	1993-12-09
SK279211B6 (sk)	1998-08-05
FI945694A0 (fi)	1994-12-02
WO1993025547A1 (en)	1993-12-23
CZ282060B6 (cs)	1997-05-14
NO307420B1 (no)	2000-04-03
DE69318212T2 (de)	1998-11-19
EP0573221A1 (en)	1993-12-08
FI106201B (fi)	2000-12-15
FI20001776L (fi)	2000-08-10
AU659311B2 (en)	1995-05-11
FI20001777L (fi)	2000-08-10
RU94046380A (ru)	1996-12-10
HUT71403A (en)	1995-11-28
JPH0641121A (ja)	1994-02-15
CN1043532C (zh)	1999-06-02
JP2619197B2 (ja)	1997-06-11
FI945694L (fi)	1994-12-02
CA2097208C (en)	2005-02-08
IL105847A (en)	1998-09-24
ATE165602T1 (de)	1998-05-15

Publication	Publication Date	Title
US5554639A (en)	1996-09-10	Medicaments
EP0573221B1 (en)	1998-04-29	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
HK1010050B (en)	1999-06-11	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
US5834502A (en)	1998-11-10	Triazolylmethyl-indole ethylamine bisulfate salt
CA2225416C (en)	2009-02-24	A triazolylmethyl-indole ethylamine bisulfate salt
HRP940225A2 (en)	1997-08-31	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy

Legal Events

Date	Code	Title	Description
2004-12-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)