GR3022356T3 - Use of lamotrigine for treating aids-related neural disorders - Google Patents

Use of lamotrigine for treating aids-related neural disorders

Info

Publication number: GR3022356T3
Authority: GR; Greece
Prior art keywords: lamotrigine; treating aids; neural disorders; related neural; aids
Prior art date: 1993-03-05

Application number

GR960402768T

Other languages

English (en)

Inventor

Anne Bousseau

Adam Doble

Erik Louvel

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-05

Filing date

1997-01-23

Publication date

1997-04-30

1997-01-23 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1997-04-30 Publication of GR3022356T3 publication Critical patent/GR3022356T3/el

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Virology (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

GR960402768T 1993-03-05 1997-01-23 Use of lamotrigine for treating aids-related neural disorders GR3022356T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9302568A FR2702148B1 (fr)	1993-03-05	1993-03-05	Application d'anticonvulsivants dans le traitement du neuro-sida.
PCT/FR1994/000210 WO1994020108A1 (fr)	1993-03-05	1994-02-25	Application de la lamotrigine dans le traitement du neuro-sida

Publications (1)

Publication Number	Publication Date
GR3022356T3 true GR3022356T3 (en)	1997-04-30

Family

ID=9444690

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR960402768T GR3022356T3 (en)	1993-03-05	1997-01-23	Use of lamotrigine for treating aids-related neural disorders
GR20010400060T GR3035957T3 (en)	1993-03-05	2001-05-31	Use of riluzole for treating aids-related neural disorders

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
GR20010400060T GR3035957T3 (en)	1993-03-05	2001-05-31	Use of riluzole for treating aids-related neural disorders

Country Status (23)

Country	Link
US (2)	US5629312A (el)
EP (3)	EP0687176B1 (el)
JP (3)	JP3578174B2 (el)
KR (3)	KR100318168B1 (el)
AT (2)	ATE147981T1 (el)
AU (3)	AU6143894A (el)
CA (3)	CA2154571A1 (el)
CZ (3)	CZ285339B6 (el)
DE (2)	DE69401577T2 (el)
DK (2)	DK0687176T3 (el)
ES (2)	ES2096455T3 (el)
FR (1)	FR2702148B1 (el)
GR (2)	GR3022356T3 (el)
HU (3)	HUT73434A (el)
IL (3)	IL108846A0 (el)
NO (3)	NO307687B1 (el)
PL (3)	PL310476A1 (el)
PT (1)	PT687176E (el)
RU (1)	RU2157205C2 (el)
SK (3)	SK279659B6 (el)
UA (1)	UA41355C2 (el)
WO (3)	WO1994020103A1 (el)
ZA (2)	ZA941530B (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5866597A (en) *	1993-03-19	1999-02-02	Glaxo Wellcome Inc.	Use of triazine compounds for the treatment of memory and learning disorders
GB9424766D0 (en) *	1994-12-07	1995-02-08	Wellcome Found	Pharmaceutical composition
GB9512854D0 (en) *	1995-06-23	1995-08-23	Wellcome Found	Novel formulation
DE19603984A1 (de) *	1996-02-05	1997-08-07	Bayer Ag	Granulate von Triazinen
US20020022056A1 (en)	1997-02-14	2002-02-21	Burkhard Schlutermann	Oxacarbazepine film-coated tablets
CO4920215A1 (es) *	1997-02-14	2000-05-29	Novartis Ag	Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones
US5922746A (en) *	1997-03-27	1999-07-13	Allergan	Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma
GB9721497D0 (en) *	1997-10-09	1997-12-10	Ciba Geigy Ag	Organic compounds
FR2774592B1 (fr) *	1998-02-06	2000-03-17	Rhone Poulenc Rorer Sa	Application du 2-amino-6-trifluoromethoxybenzothiazole pour la prevention ou le traitement des dysfonctionnements du cervelet
FR2774908B1 (fr) *	1998-02-17	2000-06-23	Centre Nat Rech Scient	Utilisation d'inhibiteur de la liberation du glutamate dans le traitement de l'ischemie retinienne
FR2787028B1 (fr)	1998-12-15	2002-10-18	Aventis Pharma Sa	Utilisation du riluzole dans le traitement des traumatismes acoustiques
WO2000066121A1 (en) *	1999-04-29	2000-11-09	Centre National De La Recherche Scientifique (C.N.R.S.)	A method for the prevention of ischemic spinal cord injury caused by aortic crossclamping
US7479498B2 (en) *	1999-08-23	2009-01-20	Phoenix Biosciences, Inc.	Treatments for viral infections
GB9925962D0 (en) *	1999-11-02	1999-12-29	Novartis Ag	Organic compounds
FR2801217B1 (fr) *	1999-11-24	2002-12-06	Aventis Pharma Sa	Association de riluzole et de gabapentine et son utilisation comme medicament
GB9930058D0 (en)	1999-12-20	2000-02-09	Novartis Ag	Organic compounds
US6207179B1 (en) *	2000-05-18	2001-03-27	Phoenix Scientific, Inc.	Parasiticidal formulation for animals and a method of making this formulation
CA2471666C (en)	2004-06-18	2009-10-13	Apotex Pharmachem Inc.	An improved process for the preparation of oxcarbazepine and related intermediates
EP2982372B1 (en) *	2005-04-05	2020-08-05	Yale University	Glutamate modulating agents in the treatment of mental disorders
US20060252745A1 (en)	2005-05-06	2006-11-09	Almeida Jose L D	Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
FR2910811B1 (fr) *	2007-01-03	2009-07-10	Ass Pour Le Dev De La Biothera	Utilisation du riluzole et de ses derives pour fabriquer de nouveaux medicaments
GB0700773D0 (en)	2007-01-15	2007-02-21	Portela & Ca Sa	Drug therapies
FR2957077B1 (fr) *	2010-03-02	2012-04-13	Univ Dauvergne Clermont I	Utilisation du riluzole pour traiter ou prevenir les effets indesirables d'agents anti-cancereux
HUE046869T2 (hu) *	2014-11-21	2020-04-28	Biohaven Therapeutics Ltd	Riluzol szublingvális formulációja
AU2022226326B2 (en) *	2021-02-24	2023-11-09	Valvoline Licensing And Intellectual Property Llc	Foaming evaporator coil cleaner

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2492258A1 (fr) *	1980-10-17	1982-04-23	Pharmindustrie	Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4431641A (en) *	1980-10-17	1984-02-14	Ciba-Geigy Corporation	Pharmaceutical compositions having antiepileptic and antineuralgic action
GB8613183D0 (en) *	1986-05-30	1986-07-02	Wellcome Found	Triazine salt
US4826860A (en) *	1987-03-16	1989-05-02	Warner-Lambert Company	Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4918090A (en) *	1988-01-25	1990-04-17	Warner-Lambert Company	Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents
EP0435826A1 (de) *	1989-12-27	1991-07-03	Ciba-Geigy Ag	Intravenöse Lösungen für Status Epilepticus
US5326570A (en) *	1991-07-23	1994-07-05	Pharmavene, Inc.	Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
FR2688138B1 (fr) *	1992-03-06	1995-05-05	Rhone Poulenc Rorer Sa	Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique.
JPH07308499A (ja) *	1994-05-20	1995-11-28	Brother Ind Ltd	衣類乾燥機

1993
- 1993-03-05 FR FR9302568A patent/FR2702148B1/fr not_active Expired - Lifetime
1994
- 1994-02-25 CA CA002154571A patent/CA2154571A1/fr not_active Abandoned
- 1994-02-25 WO PCT/FR1994/000208 patent/WO1994020103A1/fr active IP Right Grant
- 1994-02-25 PL PL94310476A patent/PL310476A1/xx unknown
- 1994-02-25 AT AT94908376T patent/ATE147981T1/de active
- 1994-02-25 DK DK94908374T patent/DK0687176T3/da active
- 1994-02-25 JP JP51964794A patent/JP3578174B2/ja not_active Expired - Fee Related
- 1994-02-25 JP JP6519649A patent/JPH08507509A/ja active Pending
- 1994-02-25 UA UA95083996A patent/UA41355C2/uk unknown
- 1994-02-25 DE DE69401577T patent/DE69401577T2/de not_active Expired - Fee Related
- 1994-02-25 CZ CZ952259A patent/CZ285339B6/cs not_active IP Right Cessation
- 1994-02-25 AU AU61438/94A patent/AU6143894A/en not_active Abandoned
- 1994-02-25 PL PL94310475A patent/PL310475A1/xx unknown
- 1994-02-25 AT AT94908374T patent/ATE201597T1/de active
- 1994-02-25 WO PCT/FR1994/000209 patent/WO1994020110A1/fr not_active Application Discontinuation
- 1994-02-25 SK SK1076-95A patent/SK279659B6/sk not_active IP Right Cessation
- 1994-02-25 AU AU61437/94A patent/AU675118B2/en not_active Ceased
- 1994-02-25 HU HU9502583A patent/HUT73434A/hu unknown
- 1994-02-25 AU AU61439/94A patent/AU675119B2/en not_active Ceased
- 1994-02-25 CZ CZ952261A patent/CZ284423B6/cs unknown
- 1994-02-25 HU HU9502584A patent/HU9502584D0/hu unknown
- 1994-02-25 WO PCT/FR1994/000210 patent/WO1994020108A1/fr active IP Right Grant
- 1994-02-25 DE DE69427344T patent/DE69427344T2/de not_active Expired - Lifetime
- 1994-02-25 CA CA002154572A patent/CA2154572C/fr not_active Expired - Fee Related
- 1994-02-25 DK DK94908376.0T patent/DK0687177T3/da active
- 1994-02-25 ES ES94908376T patent/ES2096455T3/es not_active Expired - Lifetime
- 1994-02-25 CZ CZ952260A patent/CZ226095A3/cs unknown
- 1994-02-25 SK SK1074-95A patent/SK107495A3/sk unknown
- 1994-02-25 SK SK1075-95A patent/SK107595A3/sk unknown
- 1994-02-25 US US08/530,253 patent/US5629312A/en not_active Expired - Fee Related
- 1994-02-25 EP EP94908374A patent/EP0687176B1/fr not_active Expired - Lifetime
- 1994-02-25 CA CA002154573A patent/CA2154573A1/fr not_active Abandoned
- 1994-02-25 RU RU95121731/14A patent/RU2157205C2/ru not_active IP Right Cessation
- 1994-02-25 HU HU9502585A patent/HU217132B/hu not_active IP Right Cessation
- 1994-02-25 KR KR1019950703732A patent/KR100318168B1/ko not_active IP Right Cessation
- 1994-02-25 JP JP6519648A patent/JPH08507508A/ja active Pending
- 1994-02-25 KR KR1019950703734A patent/KR960700721A/ko not_active Application Discontinuation
- 1994-02-25 ES ES94908374T patent/ES2157252T3/es not_active Expired - Lifetime
- 1994-02-25 PT PT94908374T patent/PT687176E/pt unknown
- 1994-02-25 EP EP94908376A patent/EP0687177B1/fr not_active Expired - Lifetime
- 1994-02-25 EP EP94908375A patent/EP0687179A1/fr not_active Withdrawn
- 1994-02-25 KR KR1019950703733A patent/KR960700723A/ko not_active Application Discontinuation
- 1994-02-25 PL PL94310474A patent/PL310474A1/xx unknown
- 1994-03-03 IL IL10884694A patent/IL108846A0/xx not_active IP Right Cessation
- 1994-03-03 IL IL108844A patent/IL108844A/en not_active IP Right Cessation
- 1994-03-03 IL IL10884594A patent/IL108845A0/xx unknown
- 1994-03-04 ZA ZA941530A patent/ZA941530B/xx unknown
- 1994-03-04 ZA ZA941525A patent/ZA941525B/xx unknown
1995
- 1995-02-28 US US08/396,106 patent/US5624945A/en not_active Expired - Lifetime
- 1995-08-28 NO NO953370A patent/NO307687B1/no not_active IP Right Cessation
- 1995-08-28 NO NO953371A patent/NO953371L/no unknown
- 1995-08-28 NO NO953372A patent/NO953372D0/no unknown
1997
- 1997-01-23 GR GR960402768T patent/GR3022356T3/el unknown
2001
- 2001-05-31 GR GR20010400060T patent/GR3035957T3/el unknown

Also Published As

Publication number	Publication date
NO953371D0 (no)	1995-08-28
IL108844A0 (en)	1994-06-24
UA41355C2 (uk)	2001-09-17
PL310474A1 (en)	1995-12-11
KR100318168B1 (ko)	2002-06-20
ES2096455T3 (es)	1997-03-01
US5629312A (en)	1997-05-13
AU675118B2 (en)	1997-01-23
AU6143994A (en)	1994-09-26
HU9502583D0 (en)	1995-11-28
DE69427344T2 (de)	2002-04-25
CZ284423B6 (cs)	1998-11-11
NO953372L (no)	1995-08-28
WO1994020108A1 (fr)	1994-09-15
HUT73433A (en)	1996-07-29
GR3035957T3 (en)	2001-08-31
PT687176E (pt)	2001-09-28
RU2157205C2 (ru)	2000-10-10
JPH08507507A (ja)	1996-08-13
CZ226195A3 (en)	1995-12-13
CZ225995A3 (en)	1995-12-13
DE69401577D1 (de)	1997-03-06
ATE147981T1 (de)	1997-02-15
DK0687176T3 (da)	2001-07-30
PL310475A1 (en)	1995-12-11
EP0687177B1 (fr)	1997-01-22
NO953371L (no)	1995-08-28
EP0687176A1 (fr)	1995-12-20
DE69427344D1 (de)	2001-07-05
JPH08507508A (ja)	1996-08-13
ES2157252T3 (es)	2001-08-16
IL108845A0 (en)	1994-06-24
HU9502585D0 (en)	1995-11-28
HU217132B (hu)	1999-11-29
NO953370L (no)	1995-08-28
AU675119B2 (en)	1997-01-23
IL108846A0 (en)	1994-06-24
ZA941525B (en)	1994-11-09
CA2154573A1 (fr)	1994-09-15
WO1994020110A1 (fr)	1994-09-15
PL310476A1 (en)	1995-12-11
ZA941530B (en)	1994-10-06
SK107495A3 (en)	1996-06-05
KR960700721A (ko)	1996-02-24
NO953370D0 (no)	1995-08-28
EP0687179A1 (fr)	1995-12-20
JP3578174B2 (ja)	2004-10-20
SK107595A3 (en)	1996-06-05
CZ226095A3 (en)	1995-12-13
EP0687176B1 (fr)	2001-05-30
KR960700723A (ko)	1996-02-24
NO307687B1 (no)	2000-05-15
CA2154572C (fr)	2006-06-06
JPH08507509A (ja)	1996-08-13
EP0687177A1 (fr)	1995-12-20
DE69401577T2 (de)	1997-05-15
CA2154572A1 (fr)	1994-09-15
HUT73434A (en)	1996-07-29
HU9502584D0 (en)	1995-11-28
IL108844A (en)	1998-01-04
CA2154571A1 (fr)	1994-09-15
ATE201597T1 (de)	2001-06-15
WO1994020103A1 (fr)	1994-09-15
SK107695A3 (en)	1996-06-05
DK0687177T3 (da)	1997-02-10
US5624945A (en)	1997-04-29
NO953372D0 (no)	1995-08-28
AU6143894A (en)	1994-09-26
SK279659B6 (sk)	1999-02-11
KR960700716A (ko)	1996-02-24
AU6143794A (en)	1994-09-26
CZ285339B6 (cs)	1999-07-14
FR2702148A1 (fr)	1994-09-09
FR2702148B1 (fr)	1995-04-07

Publication	Publication Date	Title
GR3022356T3 (en)	1997-04-30	Use of lamotrigine for treating aids-related neural disorders
HU912359D0 (en)	1991-12-30	The use of flupirtine active agents for treating muscle-tension
MX9600832A (es)	1997-02-28	Uso de pirazolopirimidinas y pirrolopirimidinas para la preparacion de composiciones para el tratamiento de trastornos neuronales y otros trastornos.
PT1071422E (pt)	2008-05-05	Associações de riluzole e levodopa para o tratamento da doença de parkinson
HUT70757A (en)	1995-10-30	Pharmaceutical compositions for treating skin disorders