GR1001523B - Injectable paracetamole and codein combination solutions - Google Patents
Injectable paracetamole and codein combination solutionsInfo
- Publication number
- GR1001523B GR1001523B GR910100297A GR910100297A GR1001523B GR 1001523 B GR1001523 B GR 1001523B GR 910100297 A GR910100297 A GR 910100297A GR 910100297 A GR910100297 A GR 910100297A GR 1001523 B GR1001523 B GR 1001523B
- Authority
- GR
- Greece
- Prior art keywords
- paracetamole
- codein
- injectable
- solutions
- combination solutions
- Prior art date
Links
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 title abstract 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- 229940074076 glycerol formal Drugs 0.000 abstract 1
- 229960004194 lidocaine Drugs 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229940083542 sodium Drugs 0.000 abstract 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 abstract 1
- 229940001584 sodium metabisulfite Drugs 0.000 abstract 1
- 235000010262 sodium metabisulphite Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
These solutions contain 15% w/v of paracetamole and 0.375 or 0.750% w/v of codeine (in form of phosphoric or sulphuric salt) in a system of dissolvents consisting of about 50% v/v of glycerol formal, 10% v/v of ethanol and water, as much as is needed for a volume of 4 ml (about 40% v/v). These solutions also contain lidocaine, disodium edetate, sodium metabisulfite and sodium dibasic phosphate, which ensure the stability and the conservation of the pH of the solution (4.0 - 6.0).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR91100297 | 1991-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR1001523B true GR1001523B (en) | 1994-01-28 |
Family
ID=10940738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR910100297A GR1001523B (en) | 1991-07-04 | 1991-07-04 | Injectable paracetamole and codein combination solutions |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR1001523B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916347A1 (en) * | 1997-11-18 | 1999-05-19 | Uni-Pharma Kleon Tsetis A.B.E.E., Farmakeftika Ergastiria | Pharmaceutical injectable solutions containing paracetamol and combinations of paracetamol with other active substances |
| GR1007315B (en) * | 2010-04-19 | 2011-06-14 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, | A parenteral-administration tramadol-and-paracetamol liquid composition |
| GB2577363A (en) * | 2018-07-20 | 2020-03-25 | Wockhardt Uk Ltd | Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine phosphate |
-
1991
- 1991-07-04 GR GR910100297A patent/GR1001523B/en unknown
Non-Patent Citations (1)
| Title |
|---|
| J.E.F. REYNOLDS et al.: "Martindale, The Extra Pharmacopoeia", 29th edition, February 1989, pages 32-34,1297-1299, The Pharmaceutical Press, London, GB * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916347A1 (en) * | 1997-11-18 | 1999-05-19 | Uni-Pharma Kleon Tsetis A.B.E.E., Farmakeftika Ergastiria | Pharmaceutical injectable solutions containing paracetamol and combinations of paracetamol with other active substances |
| EP1285667A2 (en) * | 1997-11-18 | 2003-02-26 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Pharmaceutical injectable solution of paracetamol and combinations of paracetamol with other active substances |
| EP1285667A3 (en) * | 1997-11-18 | 2003-03-26 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Pharmaceutical injectable solution of paracetamol and combinations of paracetamol with other active substances |
| GR1007315B (en) * | 2010-04-19 | 2011-06-14 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, | A parenteral-administration tramadol-and-paracetamol liquid composition |
| GB2577363A (en) * | 2018-07-20 | 2020-03-25 | Wockhardt Uk Ltd | Liquid pharmaceutical composition for oral administration comprising paracetamol and codeine phosphate |
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