GB986933A - Pentafluorophenyl compounds and their manufacture - Google Patents
Pentafluorophenyl compounds and their manufactureInfo
- Publication number
- GB986933A GB986933A GB3469461A GB3469461A GB986933A GB 986933 A GB986933 A GB 986933A GB 3469461 A GB3469461 A GB 3469461A GB 3469461 A GB3469461 A GB 3469461A GB 986933 A GB986933 A GB 986933A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pentafluorophenyl
- acid
- cyanide
- halide
- yield
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to compounds of the formula C6F5CH(CH3)COX, in which X is (1) a halogen atom or (2) a group OR, R being a hydrogen atom or an alkyl group of 1-3 carbon atoms or (3) a group NH2. The compounds are prepared from pentafluorophenyl methyl carbinol (C6F5CHOHCH3) by successively converting this into an a -(pentafluorophenyl) ethyl halide, reacting the halide with an alkali-metal cyanide, and hydrolysing the resulting cyanide to yield a -(pentafluorophenyl) propionic acid; the acid may then be converted into an halide or an ester or the amide, as defined above. Examples are given in which (1) pentafluorophenyl methyl carbinol and hydrobromic acid yield a -(pentafluorophenyl) ethyl bromide which (Example 2) yields a -(pentafluorophenyl) ethyl cyanide when heated with aqueous alcoholic potassium cyanide; the cyanide yields a (pentafluorophenyl) propionic acid when hydrolysed with an aqueous mixture of sulphuric and acetic acids; the p-bromophenacyl ester of the acid is described; (3) a -(pentafluorophenyl) propionic acid is esterified with ethanol in the presence of fluosulphonic acid or (Example 4) is converted into its chloride by treatment with phosphorus pentachloride; (5) a - (pentafluorophenyl) propionyl chloride is treated with ammonia to yield a -(pentafluorophenyl) propionamide. Specifications 977,964 and 977,965 also are referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3469461A GB986933A (en) | 1961-09-27 | 1961-09-27 | Pentafluorophenyl compounds and their manufacture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3469461A GB986933A (en) | 1961-09-27 | 1961-09-27 | Pentafluorophenyl compounds and their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB986933A true GB986933A (en) | 1965-03-24 |
Family
ID=10368798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3469461A Expired GB986933A (en) | 1961-09-27 | 1961-09-27 | Pentafluorophenyl compounds and their manufacture |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB986933A (en) |
-
1961
- 1961-09-27 GB GB3469461A patent/GB986933A/en not_active Expired
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