GB952636A - Production of 6.8-dithiooctanamides - Google Patents
Production of 6.8-dithiooctanamidesInfo
- Publication number
- GB952636A GB952636A GB3501960A GB3501960A GB952636A GB 952636 A GB952636 A GB 952636A GB 3501960 A GB3501960 A GB 3501960A GB 3501960 A GB3501960 A GB 3501960A GB 952636 A GB952636 A GB 952636A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dithio
- formula
- octanoyl
- produce
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises (1) compounds of the formula: <FORM:0952636/C2/1> (wherein R and R1 are hydrogen atoms, alkyl radicals of 3 to 5 carbon atoms or aryl radicals, or -NRR1 is the residue of isonicotinic acid hydrazide, or an a -amino-acid or a C1-5-te alkyl ether thereof, with the proviso that when one of R and R1 is hydrogen the other cannot be hydrogen or aryl); and (2) the preparation of compounds of the above general formula wherein R and R1 have the above defined values without the limitation of the proviso and without a lower limit on the number of carbon atoms in the alkyl radicals, by reacting a compound of the formula: <FORM:0952636/C2/2> (wherein X and X1 are halogen atoms) either with sodium disulphide to produce the desired product or with an alkali metal thiosulphate to produce a compound of the formula: <FORM:0952636/C2/3> (wherein M is the alkali metal) and then heating this to produce the desired product, and, if desired, treating the reaction mixture with a caustic alkali to convert undesired by-products to the desired final product. In this process a-amino acid alkyl ester residues are hydrolysed to g -amino acid residues. Examples describe the preparation of 6, 8-dithio-octanamide; N-diisopropyl 6, 8-dithio-octanamide; N-(6, 8-dithio-octanoyl) -L- glutamic acid; N-(6, 8-dithio-octanoyl)-DL-methionine; 6, 8-dithio-octanilide; and 1-isonicotinoyl -2- (6, 8-dithio-octanoyl) - hydrazine hydrochloride. Specification 952,637 is referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3246859 | 1959-10-13 | ||
| JP3246759 | 1959-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB952636A true GB952636A (en) | 1964-03-18 |
Family
ID=26371046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3501960A Expired GB952636A (en) | 1959-10-13 | 1960-10-12 | Production of 6.8-dithiooctanamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB952636A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284466A (en) * | 1963-07-12 | 1966-11-08 | Thiokol Chemical Corp | Preparation of monomeric disulfides |
| US3288797A (en) * | 1963-08-20 | 1966-11-29 | Merck Ag E | Lipoic acid derivatives and their preparation |
-
1960
- 1960-10-12 GB GB3501960A patent/GB952636A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284466A (en) * | 1963-07-12 | 1966-11-08 | Thiokol Chemical Corp | Preparation of monomeric disulfides |
| US3288797A (en) * | 1963-08-20 | 1966-11-29 | Merck Ag E | Lipoic acid derivatives and their preparation |
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