GB967610A - Sustained release medicament formulations - Google Patents
Sustained release medicament formulationsInfo
- Publication number
- GB967610A GB967610A GB38360/62A GB3836062A GB967610A GB 967610 A GB967610 A GB 967610A GB 38360/62 A GB38360/62 A GB 38360/62A GB 3836062 A GB3836062 A GB 3836062A GB 967610 A GB967610 A GB 967610A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polyoxyethylene glycol
- medicament
- tablets
- esters
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 11
- 239000000203 mixture Substances 0.000 title abstract 10
- 238000009472 formulation Methods 0.000 title abstract 4
- 238000013268 sustained release Methods 0.000 title abstract 4
- 239000012730 sustained-release form Substances 0.000 title abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 14
- -1 polyoxyethylene Polymers 0.000 abstract 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 9
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 8
- 239000003826 tablet Substances 0.000 abstract 7
- 239000008188 pellet Substances 0.000 abstract 6
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 4
- 235000021355 Stearic acid Nutrition 0.000 abstract 3
- 239000002775 capsule Substances 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 3
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 3
- 239000008117 stearic acid Substances 0.000 abstract 3
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 2
- ISFHAYSTHMVOJR-UHFFFAOYSA-N Phenindamine Chemical compound C1N(C)CCC(C2=CC=CC=C22)=C1C2C1=CC=CC=C1 ISFHAYSTHMVOJR-UHFFFAOYSA-N 0.000 abstract 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 abstract 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 2
- 238000002844 melting Methods 0.000 abstract 2
- 229960003893 phenacetin Drugs 0.000 abstract 2
- 229960003534 phenindamine Drugs 0.000 abstract 2
- 229960001802 phenylephrine Drugs 0.000 abstract 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 abstract 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 abstract 2
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 abstract 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 abstract 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
- VATIMCNDILNPMW-UHFFFAOYSA-N 7-chloro-1h-diazepine Chemical compound ClC1=CC=CC=NN1 VATIMCNDILNPMW-UHFFFAOYSA-N 0.000 abstract 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
- BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000005639 Lauric acid Substances 0.000 abstract 1
- TXPPKWZEHFNZOE-UHFFFAOYSA-N O-Methylcorypalline Natural products C1CN(C)CC2=C1C=C(OC)C(OC)=C2 TXPPKWZEHFNZOE-UHFFFAOYSA-N 0.000 abstract 1
- 239000005642 Oleic acid Substances 0.000 abstract 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- PYHRZPFZZDCOPH-UHFFFAOYSA-N amphetamine sulfate Chemical compound OS(O)(=O)=O.CC(N)CC1=CC=CC=C1.CC(N)CC1=CC=CC=C1 PYHRZPFZZDCOPH-UHFFFAOYSA-N 0.000 abstract 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 abstract 1
- 235000013871 bee wax Nutrition 0.000 abstract 1
- 239000012166 beeswax Substances 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 235000013869 carnauba wax Nutrition 0.000 abstract 1
- 239000004203 carnauba wax Substances 0.000 abstract 1
- 229960004725 chlordiazepoxide hydrochloride Drugs 0.000 abstract 1
- DMLFJMQTNDSRFU-UHFFFAOYSA-N chlordiazepoxide hydrochloride Chemical compound Cl.O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 DMLFJMQTNDSRFU-UHFFFAOYSA-N 0.000 abstract 1
- GKEGFOKQMZHVOW-KUTGSRRKSA-M clidinium bromide Chemical compound [Br-].C1([C@H]2CC[N@+](CC2)(C1)C)OC(=O)C(O)(C=1C=CC=CC=1)C1=CC=CC=C1 GKEGFOKQMZHVOW-KUTGSRRKSA-M 0.000 abstract 1
- 229960005098 clidinium bromide Drugs 0.000 abstract 1
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 235000019961 diglycerides of fatty acid Nutrition 0.000 abstract 1
- 229960002534 ephedrine hydrochloride Drugs 0.000 abstract 1
- 230000003628 erosive effect Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 125000005908 glyceryl ester group Chemical group 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 235000021003 saturated fats Nutrition 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14642261A | 1961-10-20 | 1961-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB967610A true GB967610A (en) | 1964-08-26 |
Family
ID=22517286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38360/62A Expired GB967610A (en) | 1961-10-20 | 1962-10-10 | Sustained release medicament formulations |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE623704A (hu) |
| DE (1) | DE1219176B (hu) |
| ES (1) | ES281704A1 (hu) |
| FR (1) | FR2172M (hu) |
| GB (1) | GB967610A (hu) |
| MY (1) | MY6600083A (hu) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2254109A1 (de) * | 1971-11-17 | 1973-05-24 | Colgate Palmolive Co | Koerniges material, insbesondere zur verwendung in zahnreinigungsmitteln, sowie verfahren zu dessen herstellung |
| US4289795A (en) * | 1975-11-17 | 1981-09-15 | Aktiebolaget Hassle | Method for preparing preparations having controlled release of an active component |
| EP0177368A2 (en) * | 1984-10-05 | 1986-04-09 | Warner-Lambert Company | A novel drug delivery system and method of preparation thereof |
| EP0190255A1 (en) * | 1984-07-23 | 1986-08-13 | Zetachron Inc | BIOACTIVE COMPOSITION WITH PERMANENT ADMINISTRATION. |
| US4804548A (en) * | 1984-10-05 | 1989-02-14 | Warner-Lambert Company | Novel sweetener delivery systems |
| US4828857A (en) * | 1984-10-05 | 1989-05-09 | Warner-Lambert Company | Novel sweetener delivery systems |
| US5082655A (en) * | 1984-07-23 | 1992-01-21 | Zetachron, Inc. | Pharmaceutical composition for drugs subject to supercooling |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3217071A1 (de) * | 1982-05-06 | 1983-11-10 | Rüdiger Dr. 6365 Rosbach Gröning | Arzneimittel fuer die perorale applikation mit verbesserter biologischer verfuegbarkeit der wirkstoffe |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2918411A (en) * | 1957-11-01 | 1959-12-22 | Olin Mathieson | Pharmaceutical preparations |
-
0
- BE BE623704D patent/BE623704A/xx unknown
-
1962
- 1962-09-28 DE DEH47032A patent/DE1219176B/de active Pending
- 1962-10-10 GB GB38360/62A patent/GB967610A/en not_active Expired
- 1962-10-18 FR FR912603A patent/FR2172M/fr not_active Expired
- 1962-10-19 ES ES0281704A patent/ES281704A1/es not_active Expired
-
1966
- 1966-12-31 MY MY6600083A patent/MY6600083A/xx unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2254109A1 (de) * | 1971-11-17 | 1973-05-24 | Colgate Palmolive Co | Koerniges material, insbesondere zur verwendung in zahnreinigungsmitteln, sowie verfahren zu dessen herstellung |
| US4289795A (en) * | 1975-11-17 | 1981-09-15 | Aktiebolaget Hassle | Method for preparing preparations having controlled release of an active component |
| US4341759A (en) * | 1975-11-17 | 1982-07-27 | Aktiebolaget Hassle | Granule having controlled release properties |
| EP0190255A1 (en) * | 1984-07-23 | 1986-08-13 | Zetachron Inc | BIOACTIVE COMPOSITION WITH PERMANENT ADMINISTRATION. |
| EP0190255A4 (en) * | 1984-07-23 | 1987-10-20 | Zetachron Inc | ERODABLE MATRIX FOR SUSTAINED RELEASE BIOACTIVE COMPOSITIONS. |
| US5082655A (en) * | 1984-07-23 | 1992-01-21 | Zetachron, Inc. | Pharmaceutical composition for drugs subject to supercooling |
| EP0177368A2 (en) * | 1984-10-05 | 1986-04-09 | Warner-Lambert Company | A novel drug delivery system and method of preparation thereof |
| EP0177368A3 (en) * | 1984-10-05 | 1987-12-02 | Warner-Lambert Company | A novel drug delivery system and method of preparation thereof |
| US4804548A (en) * | 1984-10-05 | 1989-02-14 | Warner-Lambert Company | Novel sweetener delivery systems |
| US4828857A (en) * | 1984-10-05 | 1989-05-09 | Warner-Lambert Company | Novel sweetener delivery systems |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2172M (fr) | 1963-11-25 |
| DE1219176B (de) | 1966-06-16 |
| BE623704A (hu) | |
| ES281704A1 (es) | 1963-04-16 |
| MY6600083A (en) | 1966-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1030127A (en) | Improvements in or relating to method of preparing sustained release pharmaceutical pellets and product thereof | |
| US6596308B2 (en) | Controlled release pharmaceutical composition | |
| US6491950B1 (en) | Controlled release pharmaceutical composition | |
| US4983399A (en) | Direct compression carrier composition | |
| US3082154A (en) | Improved free-flowing coated antimalarial salts in particulate form | |
| AU594264B2 (en) | Therapeutic agents | |
| PT98879A (pt) | Processo para a preparacao de microcapsulas mascaveis esferoidais revestidas | |
| JP2005508301A5 (hu) | ||
| GB967610A (en) | Sustained release medicament formulations | |
| BRPI0009373B1 (pt) | Composições farmacêuticas orais contendo triglicerídeos de cadeia longa e tensoativos lipofílicos | |
| US3061510A (en) | Radioactive iodinated (i131) fatty material admixed with wax-like material in capsule | |
| US5736542A (en) | Pharmaceutical compositions containing a staurosporine | |
| EP0574221A1 (en) | Pharmaceutical stable formulations of nicorandil | |
| SK283442B6 (sk) | Farmaceutický prípravok na orálne podanie | |
| JP2007145831A (ja) | 還元型補酵素ｑ１０を安定化するための方法 | |
| EP0230332A1 (en) | A pharmaceutical composition with sustained release of the active component and a process for the preparation thereof | |
| US3450821A (en) | Stable compositions containing eicosatetrayn - (5,8,11,14) - oic-(1) acid and derivatives thereof | |
| IE33480B1 (en) | Pharmaceutical preparation | |
| GB1443923A (en) | Sustained release compositions | |
| US2895881A (en) | Quinidine gluconate sustained medication tablet | |
| ES2205887T3 (es) | Comprimido para masticar de sabor enmascarado, liberacion inmediata del principio activo y procedimiento de fabricacion. | |
| JPH07506845A (ja) | セレジリンを含有する新規組成物 | |
| JPH1045629A (ja) | 活性成分の調節放出のための安定化親油性マトリックスを基本とする医薬組成物 | |
| US11690835B2 (en) | Formulation | |
| CN102406619A (zh) | 一种缓释微丸及其制备方法 |