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GB965350A - Process for preparing 5-inosinic acid - Google Patents

Process for preparing 5-inosinic acid

Info

Publication number
GB965350A
GB965350A GB4524862A GB4524862A GB965350A GB 965350 A GB965350 A GB 965350A GB 4524862 A GB4524862 A GB 4524862A GB 4524862 A GB4524862 A GB 4524862A GB 965350 A GB965350 A GB 965350A
Authority
GB
United Kingdom
Prior art keywords
inosinic acid
inosine
phosphate
nucleotides
phosphates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4524862A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB965350A publication Critical patent/GB965350A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

51-Inosinic acid is obtained by admixing a solution containing inosine and a phosphate donor comprising one or more aromatic phosphates and/or one or more nucleotides other than 51-inosinic acid with an enzyme source comprising or obtained from cells of a species of microorganism belonging to the genus Pseudomonas, allowing biochemical phosphorylation of the inosine to take place while maintaining the pH from 3.5 to 7.0, and thereafter recovering the accumulated 51-inosinic acid, e.g. by an ionexchange method as the sodium salt. Suitable aromatic phosphates include nitrophenyl phosphates, phenyl phosphate and benzyl phosphate and their salts. Copper and/or zinc ions are preferably present. When the inosine is contaminated with other nucleosides such as adenosine and guanosine, the corresponding 51-nucleotides are produced as by-products.
GB4524862A 1961-12-13 1962-11-29 Process for preparing 5-inosinic acid Expired GB965350A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4481761 1961-12-13

Publications (1)

Publication Number Publication Date
GB965350A true GB965350A (en) 1964-07-29

Family

ID=12701971

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4524862A Expired GB965350A (en) 1961-12-13 1962-11-29 Process for preparing 5-inosinic acid

Country Status (3)

Country Link
CH (1) CH409977A (en)
DE (1) DE1232967B (en)
GB (1) GB965350A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022550340A (en) * 2019-10-17 2022-12-01 シージェイ チェイルジェダン コーポレーション Method for separating disodium 5'-inosinate

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022550340A (en) * 2019-10-17 2022-12-01 シージェイ チェイルジェダン コーポレーション Method for separating disodium 5'-inosinate
EP4032898A4 (en) * 2019-10-17 2023-11-08 CJ Cheiljedang Corporation Method for separating disodium 5'-inosinate
JP7404518B2 (en) 2019-10-17 2023-12-25 シージェイ チェイルジェダン コーポレーション Separation method of 5'-inosinate disodium

Also Published As

Publication number Publication date
CH409977A (en) 1966-03-31
DE1232967B (en) 1967-01-26

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