GB938322A - A process for the production of 5-guanylic acid - Google Patents
A process for the production of 5-guanylic acidInfo
- Publication number
- GB938322A GB938322A GB1176562A GB1176562A GB938322A GB 938322 A GB938322 A GB 938322A GB 1176562 A GB1176562 A GB 1176562A GB 1176562 A GB1176562 A GB 1176562A GB 938322 A GB938322 A GB 938322A
- Authority
- GB
- United Kingdom
- Prior art keywords
- guanylic acid
- nucleotides
- guanosine
- phosphate
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
51-Guanylic acid is prepared by adding to a solution containing guanosine and a phosphate donor comprising one or more aromatic phosphates and/or one or more nucleotides other than 51-guanylic acid an enzyme source comprising or obtained from cells of a species of microorganism selected from the genera Flavobacterium, Serratia, Staphylococcus and Pseudomonas, allowing biochemical phosphorylation of the guanosine to take place while maintaining the pH from 3,5 to 4,0 and thereafter recovering the accumulated 51-guanylic acid. Suitable aromatic phosphates include nitrophenyl phosphates, phenyl phosphate, benzyl phosphate and their salts. Copper and/or zinc ions are preferably present. The product may be recovered by separating the cells, extracting liberated phenol with an organic solvent, absorbing the guanylic acid on an ion-exchange resin, eluting with a mixture of HCl and NaCl, concentrating the eluate and adding ethanol to precipitate sodium 51-guanylate. The guanosine starting material may be derived from a fermentation process and may contain other nucleotides which are converted to their nucleotides such as 51-inosinic and 51-adenylic acids as byproducts.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1003061 | 1961-03-27 | ||
| JP97862 | 1962-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB938322A true GB938322A (en) | 1963-10-02 |
Family
ID=26334108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1176562A Expired GB938322A (en) | 1961-03-27 | 1962-03-27 | A process for the production of 5-guanylic acid |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH411905A (en) |
| GB (1) | GB938322A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1570022B1 (en) * | 1964-03-09 | 1972-02-03 | Kyowa Hakko Kogyo Kk | Process for the production of 5'-purine nucleotides by fermentation of microorganisms in an aqueous nutrient medium |
-
1962
- 1962-03-27 GB GB1176562A patent/GB938322A/en not_active Expired
- 1962-03-27 CH CH364662A patent/CH411905A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1570022B1 (en) * | 1964-03-09 | 1972-02-03 | Kyowa Hakko Kogyo Kk | Process for the production of 5'-purine nucleotides by fermentation of microorganisms in an aqueous nutrient medium |
Also Published As
| Publication number | Publication date |
|---|---|
| CH411905A (en) | 1966-04-30 |
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