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GB921533A - Cyclopentanophenanthrene derivatives and process for the production thereof - Google Patents

Cyclopentanophenanthrene derivatives and process for the production thereof

Info

Publication number
GB921533A
GB921533A GB2382559A GB2382559A GB921533A GB 921533 A GB921533 A GB 921533A GB 2382559 A GB2382559 A GB 2382559A GB 2382559 A GB2382559 A GB 2382559A GB 921533 A GB921533 A GB 921533A
Authority
GB
United Kingdom
Prior art keywords
group
double bond
keto
hydroxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2382559A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex SA
Original Assignee
Syntex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex SA filed Critical Syntex SA
Publication of GB921533A publication Critical patent/GB921533A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the formula:- <FORM:0921533/IV(a)/1> wherein A is a single or a double bond between C1 and C2; X is F, Cl, or Br; Y is b -hydroxy or keto; R is hydrogen or an optionally substituted hydrocarbon carboxylic acid acyl group of less than 12 carbon atoms; and their preparation by subjecting 6a ,16a -dimethyl-D 4-pregnene-17a ,21-diol-3,20-dione to a fermentative oxygenation with Rhizopus nigricans or Aspergillus niger to introduce an 11a -hydroxyl group and transforming the ensuing triol by dehydration at C9-C11, addition of the elements of hypobromous acid to the resulting double bond, epoxide ring closure, ring opening with HF or HCl and optionally oxidation of the 11b -hydroxy group to an 11-keto group and/or esterification and/or dehydrogenation with SeO2 to form the corresponding D 1 compounds. Specification 921,534 is referred to.
GB2382559A 1958-07-12 1959-07-10 Cyclopentanophenanthrene derivatives and process for the production thereof Expired GB921533A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX5155158 1958-07-12

Publications (1)

Publication Number Publication Date
GB921533A true GB921533A (en) 1963-03-20

Family

ID=19742857

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2382559A Expired GB921533A (en) 1958-07-12 1959-07-10 Cyclopentanophenanthrene derivatives and process for the production thereof

Country Status (1)

Country Link
GB (1) GB921533A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110041A1 (en) * 1982-11-22 1984-06-13 Schering Aktiengesellschaft 6-Alpha-methyl-corticoids, their preparation and utilization

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110041A1 (en) * 1982-11-22 1984-06-13 Schering Aktiengesellschaft 6-Alpha-methyl-corticoids, their preparation and utilization

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