GB920270A - Improvements in or relating to the production of steroid derivatives - Google Patents
Improvements in or relating to the production of steroid derivativesInfo
- Publication number
- GB920270A GB920270A GB3470259A GB3470259A GB920270A GB 920270 A GB920270 A GB 920270A GB 3470259 A GB3470259 A GB 3470259A GB 3470259 A GB3470259 A GB 3470259A GB 920270 A GB920270 A GB 920270A
- Authority
- GB
- United Kingdom
- Prior art keywords
- keto
- group
- acyloxylation
- acyloxy
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
21-Acyloxy-20-keto steroids are prepared by 21-acyloxylation of the 21-unsubstituted keto steroid using a lead tetraacylate in the presence of boron trifluoride and in a solvent medium comprising a mixture of a hydrocarbon solvent and an alcohol. Preferably the reaction is effected at room temperature with lead tetraacetate and boron trifluoride etherate in a benzene-methanol mixture. The process is suitable for the acyloxylation of pregnane-20-ones of the 5a - and 5b -series containing, if desired, a keto, acyloxy or hydroxy group at C3, a keto group at C11, a keto group at C12 and/or a methyl group at C16, and which may be unsaturated at one or more of the following positions 1(2), 4(5), 5(6), 9(11) and 16(17). The invention is illustrated by 8 detailed examples.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3470259A GB920270A (en) | 1959-10-13 | 1959-10-13 | Improvements in or relating to the production of steroid derivatives |
| BE595951A BE595951A (en) | 1959-10-13 | 1960-10-12 | Improvements in the production of steroid compounds. |
| BR12344160A BR6023441D0 (en) | 1959-10-13 | 1960-10-13 | PERFECT PROCESS FOR A-21-ACETROXYLATION OF 20 KETO-STEROIDS |
| CH1149460A CH385198A (en) | 1959-10-13 | 1960-10-13 | Process for making keto steroids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3470259A GB920270A (en) | 1959-10-13 | 1959-10-13 | Improvements in or relating to the production of steroid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB920270A true GB920270A (en) | 1963-03-06 |
Family
ID=10368898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3470259A Expired GB920270A (en) | 1959-10-13 | 1959-10-13 | Improvements in or relating to the production of steroid derivatives |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE595951A (en) |
| BR (1) | BR6023441D0 (en) |
| CH (1) | CH385198A (en) |
| GB (1) | GB920270A (en) |
-
1959
- 1959-10-13 GB GB3470259A patent/GB920270A/en not_active Expired
-
1960
- 1960-10-12 BE BE595951A patent/BE595951A/en unknown
- 1960-10-13 BR BR12344160A patent/BR6023441D0/en unknown
- 1960-10-13 CH CH1149460A patent/CH385198A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH385198A (en) | 1964-12-15 |
| BE595951A (en) | 1961-04-12 |
| BR6023441D0 (en) | 1973-05-24 |
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