GB914455A - Novel sulphonamides and a process for the manufacture thereof - Google Patents
Novel sulphonamides and a process for the manufacture thereofInfo
- Publication number
- GB914455A GB914455A GB3731/61A GB373161A GB914455A GB 914455 A GB914455 A GB 914455A GB 3731/61 A GB3731/61 A GB 3731/61A GB 373161 A GB373161 A GB 373161A GB 914455 A GB914455 A GB 914455A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphanilamido
- pyrimidine
- salts
- manufacture
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- AOEHEEBFRCAFGC-UHFFFAOYSA-N 2,4-dibromopyrimidine Chemical compound BrC1=CC=NC(Br)=N1 AOEHEEBFRCAFGC-UHFFFAOYSA-N 0.000 abstract 1
- OWKYCEXJWCVTMS-UHFFFAOYSA-N 2,4-diiodopyrimidine Chemical compound IC1=CC=NC(I)=N1 OWKYCEXJWCVTMS-UHFFFAOYSA-N 0.000 abstract 1
- QXUYFGZMPLMRLI-UHFFFAOYSA-N 4-amino-n-(4-chloropyrimidin-2-yl)benzenesulfonamide Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC(Cl)=N1 QXUYFGZMPLMRLI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 4-sulphanilamido-6-halogeno-pyrimidines such as 4-sulphanilamido-6-chloro-pyrimidine, and salts thereof; and comprises also the preparation of these compounds by reacting a 4,6-dihalo-pyrimidine, e.g. 4,6-dichloro-, dibromo- or diiodopyrimidine, with the sodium salt of sulphanilamide. Pharmaceutical preparations having antibacterial activity comprise the above compounds of the invention in association with an organic or inorganic, solid or liquid carrier suitable for enteral or parenteral administration. The preparations suitably take the form of tablets, dragees, suppositories, capsules, solutions, emulsions or suspensions and may contain emulsifying, preserving, stabilizing or wetting agents, salts for varying the osmolic pressure or buffers, and other therapeutically useful substances.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH155060 | 1960-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB914455A true GB914455A (en) | 1963-01-02 |
Family
ID=4213021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3731/61A Expired GB914455A (en) | 1960-02-12 | 1961-02-01 | Novel sulphonamides and a process for the manufacture thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE600035A (en) |
ES (1) | ES264827A1 (en) |
FR (1) | FR916M (en) |
GB (1) | GB914455A (en) |
NL (1) | NL260980A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459742A (en) * | 1965-06-01 | 1969-08-05 | Hoffmann La Roche | Sulfanilamide derivatives and processes |
-
0
- BE BE600035D patent/BE600035A/xx unknown
- NL NL260980D patent/NL260980A/xx unknown
-
1961
- 1961-02-01 GB GB3731/61A patent/GB914455A/en not_active Expired
- 1961-02-10 FR FR852244A patent/FR916M/fr active Active
- 1961-02-11 ES ES0264827A patent/ES264827A1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459742A (en) * | 1965-06-01 | 1969-08-05 | Hoffmann La Roche | Sulfanilamide derivatives and processes |
Also Published As
Publication number | Publication date |
---|---|
ES264827A1 (en) | 1961-08-01 |
FR916M (en) | 1961-11-06 |
BE600035A (en) | |
NL260980A (en) |
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