GB893418A - Process for the production of penicillin-splitting enzyme preparations - Google Patents
Process for the production of penicillin-splitting enzyme preparationsInfo
- Publication number
- GB893418A GB893418A GB30748/60A GB3074860A GB893418A GB 893418 A GB893418 A GB 893418A GB 30748/60 A GB30748/60 A GB 30748/60A GB 3074860 A GB3074860 A GB 3074860A GB 893418 A GB893418 A GB 893418A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- phenyl
- enzyme preparations
- splitting
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/84—Penicillin amidase (3.5.1.11)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Penicillin-splitting enzyme preparations are produced by cultivating, according to conventional methods, penicillin-splitting bacteria, such as Escherichie coli ATCC 11105, under aeration in nutrient solutions which contain at most insignificant quantities of fermentable carbohydrates and to which phenyl-acetic acid or derivatives thereof are added in quantities of 0.002%-2%, based on the nutrient solution. Preferably corn steep liquor is used as the main basic nutrient medium and carbon dioxide is introduced during the period of growth. The phenyl-acetic acid derivative may be the potassium salt or may be phenyl-acetamide, phenaceturic acid or phenacetyl-glutamic acid. Examples describe the use of the preparations in deactivating penicillin G.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE893418X | 1959-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB893418A true GB893418A (en) | 1962-04-11 |
Family
ID=6846734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30748/60A Expired GB893418A (en) | 1959-09-24 | 1960-09-06 | Process for the production of penicillin-splitting enzyme preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB893418A (en) |
-
1960
- 1960-09-06 GB GB30748/60A patent/GB893418A/en not_active Expired
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