GB875400A - Process for the preparation of vitamin b - Google Patents
Process for the preparation of vitamin bInfo
- Publication number
- GB875400A GB875400A GB40619/58A GB4061958A GB875400A GB 875400 A GB875400 A GB 875400A GB 40619/58 A GB40619/58 A GB 40619/58A GB 4061958 A GB4061958 A GB 4061958A GB 875400 A GB875400 A GB 875400A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vitamin
- source
- nutrient medium
- circulans
- coagulans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 5
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 5
- 239000011715 vitamin B12 Substances 0.000 abstract 5
- 235000019163 vitamin B12 Nutrition 0.000 abstract 5
- 235000015097 nutrients Nutrition 0.000 abstract 4
- 241000193752 Bacillus circulans Species 0.000 abstract 2
- 241000193749 Bacillus coagulans Species 0.000 abstract 2
- 241000193385 Geobacillus stearothermophilus Species 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910001429 cobalt ion Inorganic materials 0.000 abstract 2
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 150000002739 metals Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000006052 feed supplement Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Vitamin B12 is obtained in a process which comprises incubating a nutrient medium inoculated with a known vitamin B12 producing strain of a thermophilic organism which grows at a temperature above 45 DEG C. e.g. B. stearothermophilus, B. coagulans, and B. circulans. Suitably the nutrient medium contains a source of amino acid, a source of cobalt ion, trace metals and a buffer. Preferably the fermentation is effected under aerobic conditions at a pH between 6.0-7.5.ALSO:An animal feed supplement is obtained in a process which comprises inoculating a nutrient medium with a known vitamin B12 producing strain of a thermophilic organism which grows at a temperature above 45 DEG C, maintaining the growth under submerged aerobic conditions at temperatures preferably in the range 55 DEG -75 DEG C., preferably with agitation until the maximum content of vitamin B12 has been attained, and recovering a concentrate of vitamin B12 from the medium by conventional methods e.g. heating, addition of acid and evaporation. Specified organisms are B. stearothermophilus, B. coagulans and B. circulans. Suitably the nutrient medium contains a source of amino acid, a source of cobalt ion, trace metals and a buffer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875400XA | 1957-12-23 | 1957-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB875400A true GB875400A (en) | 1961-08-16 |
Family
ID=22205781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40619/58A Expired GB875400A (en) | 1957-12-23 | 1958-12-16 | Process for the preparation of vitamin b |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB875400A (en) |
-
1958
- 1958-12-16 GB GB40619/58A patent/GB875400A/en not_active Expired
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